Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells. (Q40972388)

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10 November 2019

title

Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells (English)

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10 November 2019

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1

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10 November 2019

Uwe Kordes

3

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10 November 2019

author name string

F Emmerich

2

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10 November 2019

E Scharschmidt

4

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10 November 2019

B Dörken

5

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10 November 2019

C Scheidereit

6

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10 November 2019

language of work or name

English

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publication date

1 January 1999

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10 November 2019

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10 November 2019

volume

18

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10 November 2019

issue

4

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10 November 2019

page(s)

943-953

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Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of I kappa B-alpha

10 November 2019

cites work

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Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

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Constitutive phosphorylation of I kappa B alpha by casein kinase II

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I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention

21 January 2018

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Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice

21 January 2018

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An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

21 January 2018

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Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

21 January 2018

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Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

21 January 2018

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Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

21 January 2018

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Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

21 January 2018

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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

21 January 2018

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The PEST-like sequence of I kappa B alpha is responsible for inhibition of DNA binding but not for cytoplasmic retention of c-Rel or RelA homodimers

21 January 2018

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Lymphotoxin, tumour necrosis factor and interleukin-6 gene transcripts are present in Hodgkin and Reed-Sternberg cells of most Hodgkin's disease cases.

21 January 2018

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I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding

21 January 2018

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Clinically relevant findings

21 January 2018

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Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B

21 January 2018

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Alternative splicing variants of IkappaB beta establish differential NF-kappaB signal responsiveness in human cells

21 January 2018

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Constitutive NF-kappa B activity in neurons

21 January 2018

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Rel/NF-kappa B and I kappa B factors in oncogenesis

21 January 2018

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

21 January 2018

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Catalysis by a multiprotein IkappaB kinase complex

21 January 2018

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Rel/NF-kappa B and I kappa B proteins: an overview

21 January 2018

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IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

21 January 2018

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Enhanced I kappa B alpha degradation is responsible for constitutive NF-kappa B activity in mature murine B-cell lines

21 January 2018

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Novel IkappaB alpha proteolytic pathway in WEHI231 immature B cells

21 January 2018

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

21 January 2018

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Identification and characterization of an IkappaB kinase

21 January 2018

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Inducible degradation of I kappa B alpha in vitro and in vivo requires the acidic C-terminal domain of the protein

21 January 2018

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Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo

21 January 2018

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Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

21 January 2018

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Ikappa Balpha is a target for the mitogen-activated 90kDa ribosomal S6 kinase

21 January 2018

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Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism

21 January 2018

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Structure, regulation and function of NF-kappa B

21 January 2018

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Rel/NF-kappa B transcription factors and the control of apoptosis

21 January 2018

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Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer

21 January 2018

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NF-kappaB activation: the I kappaB kinase revealed?

21 January 2018

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Suppression of TNF-alpha-induced apoptosis by NF-kappaB

21 January 2018

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Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

21 January 2018

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Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression.

21 January 2018

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Regulation of NFKB1 proteins by the candidate oncoprotein BCL-3: generation of NF-kappa B homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation

21 January 2018

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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

21 January 2018

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N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity

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21 January 2018

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21 January 2018

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The NF-kappa B/Rel and I kappa B gene families: mediators of immune response and inflammation

21 January 2018

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21 January 2018

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21 January 2018

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Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

21 January 2018

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

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The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro

21 January 2018

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7 January 2021

Common structural constituents confer I kappa B activity to NF-kappa B p105 and I kappa B/MAD-3.

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7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202351

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7 January 2021

Regulation of NF-kappa B activity by I kappa B alpha and I kappa B beta stability

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7 January 2021

Different mechanisms control signal-induced degradation and basal turnover of the NF-kappaB inhibitor IkappaB alpha in vivo

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7 January 2021

Single cell analysis of Hodgkin/Reed-Sternberg cells

1 reference

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7 January 2021

In vivo control of NF-kappa B activation by I kappa B alpha.

1 reference

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7 January 2021

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli

1 reference

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7 January 2021

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1202351

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10023670%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 November 2019

1026030264

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1 reference