lincomycin (Q423428)

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chemical compound
  • Frademicina
  • Lincocin
  • Cillimycin
  • U-10149
  • Lincomycine
  • LCM
  • Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside
  • Lincomycin
  • lenkomisin
edit
Language Label Description Also known as
English
lincomycin
chemical compound
  • Frademicina
  • Lincocin
  • Cillimycin
  • U-10149
  • Lincomycine
  • LCM
  • Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside
  • Lincomycin
  • lenkomisin

Statements

chemical structure
Lincomycin.png
610 × 456; 10 KB
0 references
mass
406.214 dalton
1 reference
stated in
PubChem
PubChem CID
3000540
language of work or name
English
title
lincomycin (English)
retrieved
19 October 2016
chemical formula
C₁₈H₃₄N₂O₆S
1 reference
stated in
PubChem
PubChem CID
3000540
language of work or name
English
title
lincomycin (English)
retrieved
20 November 2016
canonical SMILES
CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O
1 reference
stated in
PubChem
PubChem CID
3000540
language of work or name
English
title
lincomycin (English)
retrieved
20 November 2016
isomeric SMILES
CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@@H](C)O
0 references
found in taxon
Streptomyces lincolnensis
23 references
stated in
Sequence analysis and heterologous expression of the lincomycin biosynthetic cluster of the type strain Streptomyces lincolnensis ATCC 25466.
stated in
Biosynthesis of the lincomycins. 2. Studies using stable isotopes on the biosynthesis of methylthiolincosaminide moiety of lincomycin A
stated in
Isolation and identification of 3-propylidene-delta 1-pyrroline-5-carboxylic acid, a biosynthetic precursor of lincomycin
stated in
Putative lmbI and lmbH genes form a single lmbIH ORF in Streptomyces lincolnensis type strain ATCC 25466.
stated in
LmbJ and LmbIH protein levels correlate with lincomycin production in Streptomyces lincolnensis
stated in
Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production
stated in
An efficient intergeneric conjugation of DNA from Escherichia coli to mycelia of the lincomycin-producer Streptomyces lincolnensis
stated in
Effects of flow field on the metabolic characteristics of Streptomyces lincolnensis in the industrial fermentation of lincomycin
stated in
Defining a kinetic mechanism for l-DOPA 2,3 dioxygenase, a single-domain type I extradiol dioxygenase from Streptomyces lincolnensis.
stated in
Co-overexpression of lmbW and metK led to increased lincomycin A production and decreased byproduct lincomycin B content in an industrial strain of Streptomyces lincolnensis
stated in
The novel transcriptional regulator LmbU promotes lincomycin biosynthesis through regulating expression of its target genes in Streptomyces lincolnensis
stated in
Global regulator BldA regulates morphological differentiation and lincomycin production in Streptomyces lincolnensis
stated in
Enhanced lincomycin production by co-overexpression of metK1 and metK2 in Streptomyces lincolnensis.
stated in
Negative Involvement of the TetR-type regulator SLCG_2919 in the regulation of lincomycin biosynthesis in
stated in
AdpAlin, a Pleiotropic Transcriptional Regulator, Is Involved in the Cascade Regulation of Lincomycin Biosynthesis in Streptomyces lincolnensis
stated in
A family of r-determinants in Streptomyces spp. that specifies inducible resistance to macrolide, lincosamide, and streptogramin type B antibiotics.
stated in
Monophenol monooxygenase and lincomysin biosynthesis in Streptomyces lincolnensis
stated in
Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11
stated in
The genes lmbB1 and lmbB2 of Streptomyces lincolnensis encode enzymes involved in the conversion of L-tyrosine to propylproline during the biosynthesis of the antibiotic lincomycin A
stated in
Biosynthesis of the lincomycins. 1. Studies using stable isotopes on the biosynthesis of the propyl- and ethyl-L-hygric acid moieties of lincomycins A and B
stated in
Developmental regulator BldD directly regulates lincomycin biosynthesis in Streptomyces lincolnensis
stated in
Effects of phosphate, glucose, and ammonium on cell growth and lincomycin production by Streptomyces lincolnensis in chemically defined media
stated in
Erratum for Hou et al., "The Novel Transcriptional Regulator LmbU Promotes Lincomycin Biosynthesis through Regulating Expression of Its Target Genes in Streptomyces lincolnensis".
legal status (medicine)
boxed warning
1 reference
reference URL
https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802
title
FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)
has part(s)
nitrogen
0 references
carbon
0 references
Commons category
Lincomycin
0 references

Identifiers

Reaxys registry number
707677
1 reference
stated in
ChEBI
ChEBI ID
6472
language of work or name
English
title
lincomycin (English)
retrieved
19 October 2016
MassBank accession ID
MSBNK-UFZ-UF410501
0 references
MSBNK-UFZ-UF410502
0 references
MSBNK-UFZ-UF410503
0 references
MSBNK-UFZ-UF410504
0 references
MSBNK-UFZ-UF410551
0 references
MSBNK-UFZ-UF410552
0 references
MSBNK-UFZ-UF410553
0 references
MSBNK-UFZ-UF410554
0 references
HSDB ID
3109
1 reference
stated in
Hazardous Substances Data Bank
HSDB ID
3109
publication date
28 October 2019
title
LINCOMYCIN (English)
retrieved
10 May 2021
MeSH descriptor ID
D008034
subject named as
Lincomycin
0 references
KEGG ID
C06812
1 reference
stated in
ChEBI
ChEBI ID
6472
language of work or name
English
title
lincomycin (English)
retrieved
19 October 2016
C14002
1 reference
stated in
ChEBI
ChEBI ID
6472
language of work or name
English
title
lincomycin (English)
retrieved
19 October 2016
D00223
1 reference
stated in
ChEBI
ChEBI ID
6472
language of work or name
English
title
lincomycin (English)
retrieved
19 October 2016
D02346
1 reference
stated in
ChEBI
ChEBI ID
6472
language of work or name
English
title
lincomycin (English)
retrieved
19 October 2016
PDB ligand ID
3QB
0 references
DeCS ID
23297
0 references
Microsoft Academic ID
2778985905
0 references
2910385908
0 references
WordNet 3.1 Synset ID
03675948-n
1 reference
stated in
GF WordNet
 
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