Adrenoceptor alpha 2A (Q4734892)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08913

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

alpha-2C adrenergic receptor binding

1 reference

8 April 2019

Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

protein homodimerization activity

1 reference

8 April 2019

Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

epinephrine binding

norepinephrine binding

1 reference

8 April 2019

Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

alpha-1B adrenergic receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913

1 reference

24 April 2018

adrenergic receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913

1 reference

16 July 2018

protein binding

1 reference

8 April 2019

Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

alpha2-adrenergic receptor activity

A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

8 April 2019

8 April 2019

An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

thioesterase binding

1 reference

8 April 2019

Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

heterotrimeric G-protein binding

1 reference

8 April 2019

An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

protein kinase binding

1 reference

8 April 2019

Structure/function analysis of alpha2A-adrenergic receptor interaction with G protein-coupled receptor kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

1 reference

8 April 2019

receptor complex

1 reference

8 April 2019

An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

integral component of plasma membrane

3 references

16 July 2018

Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913

16 July 2018

An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913

16 July 2018

Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913

basolateral plasma membrane

1 reference

8 April 2019

EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

cytoplasm

1 reference

8 April 2019

Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

integral component of plasma membrane

Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

8 April 2019

Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

8 April 2019

An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

G protein-coupled receptor signaling pathway

IBA

biological process

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913

5 references

24 April 2018

24 April 2018

A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913

24 April 2018

Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913

24 April 2018

positive regulation of epidermal growth factor-activated receptor activity

1 reference

8 April 2019

EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

activation of protein kinase B activity

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

negative regulation of insulin secretion

1 reference

8 April 2019

Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

positive regulation of MAP kinase activity

1 reference

8 April 2019

Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

negative regulation of epinephrine secretion

NAS

1 reference

8 April 2019

Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

NAS

glucose homeostasis

1 reference

8 April 2019

Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

regulation of smooth muscle contraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

1 reference

8 April 2019

positive regulation of cytokine production

1 reference

8 April 2019

EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

regulation of insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

1 reference

8 April 2019

positive regulation of cell migration

1 reference

8 April 2019

EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

positive regulation of potassium ion transport

1 reference

8 April 2019

A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

phospholipase C-activating adrenergic receptor signaling pathway

1 reference

8 April 2019

An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

positive regulation of wound healing

1 reference

8 April 2019

EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

negative regulation of norepinephrine secretion

Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

8 April 2019

Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

positive regulation of membrane protein ectodomain proteolysis

NAS

1 reference

8 April 2019

EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

negative regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

8 April 2019

Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

adenylate cyclase-inhibiting adrenergic receptor signaling pathway

1 reference

8 April 2019

An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

negative regulation of calcium ion transmembrane transporter activity

1 reference

8 April 2019

A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

cellular response to hormone stimulus

1 reference

8 April 2019

Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

regulation of vasoconstriction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

1 reference

8 April 2019

negative regulation of calcium ion-dependent exocytosis

IC

1 reference

8 April 2019

Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

Rho protein signal transduction

IC

1 reference

8 April 2019

Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

positive regulation of cell population proliferation

1 reference

8 April 2019

Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

negative regulation of calcium ion transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

intestinal absorption

1 reference

8 April 2019

EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

Ras protein signal transduction

1 reference

8 April 2019

Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

negative regulation of lipid catabolic process

1 reference

8 April 2019

Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

activation of protein kinase activity

1 reference

8 April 2019

Structure/function analysis of alpha2A-adrenergic receptor interaction with G protein-coupled receptor kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

actin cytoskeleton organization

1 reference

8 April 2019

Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

signal transduction

Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913

24 April 2018

Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08913&geneProductId=UniProtKB:P08913

24 April 2018

platelet activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

1 reference

8 April 2019

positive regulation of MAPK cascade

1 reference

8 April 2019

An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

adrenergic receptor signaling pathway

1 reference

8 April 2019

An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

1 reference

8 April 2019

A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

adenylate cyclase-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Heterodimerization of alpha 2A- and beta 1-adrenergic receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

1 reference

8 April 2019

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

6 references

8 April 2019

8 April 2019

Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

8 April 2019

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

8 April 2019

EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

receptor transactivation

2 references

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

8 April 2019

EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

IBA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08913

physically interacts with

IBA

1 reference

7117

17 August 2016

1 reference

5443

17 August 2016

1 reference

479

17 August 2016

1 reference

520

17 August 2016

1 reference

505

17 August 2016

1 reference

33

17 August 2016

1 reference

516

17 August 2016

1 reference

521

17 August 2016

1 reference

522

17 August 2016

1 reference

124

17 August 2016

1 reference

48

17 August 2016

1 reference

523

17 August 2016

1 reference

525

17 August 2016

1 reference

35

17 August 2016

1 reference

37

17 August 2016

1 reference

83

17 August 2016

1 reference

43

17 August 2016

1 reference

7461

17 August 2016

1 reference

7241

17 August 2016

1 reference

502

17 August 2016

1 reference

49

17 August 2016

1 reference

503

17 August 2016

1 reference

136

17 August 2016

1 reference

53

17 August 2016

1 reference

56

17 August 2016

1 reference

7310

17 August 2016

1 reference

499

17 August 2016

1 reference

102

English

17 August 2016

levonordefrin

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL677

epinephrine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL679

norepinephrine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1437

(−)-ephedrine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL211456

apraclonidine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200379

dipivefrin hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200833

oxymetazoline hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200791

phenoxybenzamine hydrochloride

antagonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200787

dexmedetomidine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2106195

Gene Atlas image

PBB GE ADRA2A 209869 at fs.png
732 × 530; 11 KB

0 references

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08913

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016