p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53. (Q52534736)

2 May 2018

title

p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53. (English)

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2 May 2018

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C Wasylyk

1

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2 May 2018

R Salvi

2

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2 May 2018

M Argentini

3

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2 May 2018

C Dureuil

4

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2 May 2018

I Delumeau

5

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2 May 2018

J Abecassis

6

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2 May 2018

L Debussche

7

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2 May 2018

B Wasylyk

8

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2 May 2018

language of work or name

English

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publication date

1 March 1999

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2 May 2018

published in

Oncogene

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2 May 2018

volume

18

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2 May 2018

issue

11

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2 May 2018

page(s)

1921-1934

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2 May 2018

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

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The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter

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MDM2 expression during mouse embryogenesis and the requirement of p53.

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A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

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Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

21 January 2018

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The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

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p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

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Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage

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Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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p53 tumor-suppressor gene: clues to molecular carcinogenesis

21 January 2018

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The p53-mdm-2 autoregulatory feedback loop

21 January 2018

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p53 and E2F-1 cooperate to mediate apoptosis

21 January 2018

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High prognostic significance of Mdm2/p53 co-overexpression in soft tissue sarcomas of the extremities

21 January 2018

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Interaction between the retinoblastoma protein and the oncoprotein MDM2

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

A functional p53-responsive intronic promoter is contained within the humanmdm2gene

21 January 2018

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

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Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein

21 January 2018

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

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Involvement of p53 in cell differentiation and development

21 January 2018

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7 January 2021

Transcription abnormalities potentiate apoptosis of normal human fibroblasts.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

7 January 2021

E2F: a nodal point in cell cycle regulation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202528

7 January 2021

The MDM2 oncoprotein binds specifically to RNA through its RING finger domain

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7 January 2021

MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status

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7 January 2021

P53 gene alterations in human tumors: perspectives for cancer control.

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7 January 2021

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

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7 January 2021

Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif

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7 January 2021

p53 and ATM: cell cycle, cell death, and cancer.

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Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

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7 January 2021

Conserved mechanisms of Ras regulation of evolutionary related transcription factors, Ets1 and Pointed P2

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7 January 2021

Teratogen-induced eye defects mediated by p53-dependent apoptosis

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1202528

1 reference

2 May 2018

1 reference

2 May 2018