Arthur Taub

Symptoms are the verbal and nonverbal communicative expressions of experience. At any one time, the symptom is dependent on structural changes, genetic variations, metabolic abnormalities, immunopathic and other disorders, and the totality of social, economic, and situational experience. Complaints of pain may vary with time depending on the interaction of these features in a manner not directly related to the intensity of a noxious stimulus.

Dorsal root ganglionectomy was introduced in 1975 as a procedure with theoretical advantages over dorsal rhizotomy for the treatment of intractable radicular pain. Results of the few clinical reports have been generally favorable. The authors report the largest and most comprehensively studied series to date. 61 patients (33 men, 28 women) underwent dorsal root ganglionectomy for intractable sciatica, most often monoradicular. Patients were selected for surgery only if the clinical history, physical examination, radiologic studies, and diagnostic radicular block all predicted a favorable outcome. Sciatica was markedly reduced or eliminated in 36 patients (59%). Dysesthesia following ganglionectomy was observed frequently, but not invariably (approximately 60% of cases). Dysesthesia was generally of mild or moderate severity, self-limited, and responsive to treatment.

... Report ofa Case.\p=m-\Onehundred sev-enty-two children received HDC vac-cine manufactured in Mexico: 117 via aerosol (titer of virus, 105.250% tissue culture infective dose per milliliter), and 55 by ... Jorge Fern\l=a'\ndezde Castro, MD Jos\l=e'\Luis Valdespino G\l=o'\mez,MD

... Kitahata, Luke MMD, Ph.D.; McAllister, Roseanne GMD; Taub, Arthur MD, Ph.D. Collapse Box Abstract. ... Central trigeminal nociceptors were identified in the magnocellularis portion of the dorsal horn of the first cervical segment of the spinal cord. ...

Using an extracellular microelectrode recording technique, the effects of intravenously administered morphine sulfate upon the single-unit activities of cells in Rexed lamina VII of the lumbar spinal cord were studied in cats following decerebration and spinal cord transection at L1. These neurons responded principally to high-threshold mechanical and thermal stimuli applied to a receptive field in the ipsilateral hind limbs. Morphine sulfate, 0.25, 0.5, and 1.0 mg/kg, caused dose-related suppression of the spontaneous activities of these neurons. The firing rates at maximum suppression, observed 5-10 min after administration of morphine, were 63.9 +/- 9.2 (mean +/- 1 SE), 43.0 +/- 5.4, and 26.5 +/- 6.0 per cent of the control values, respectively. Since these cells have been shown by others to be associated with the spinothalamic and spinoreticular pathways, the results suggest that the analgesic state may result from the action of morphine on the cells of origin of these major ascending pathways in the spinal cord.

Using extracellular single-unit recording techniques, effects of intravenously administered lidocaine on dorsal-horn nociceptive neurons were studied in cats made decerebrate whose spinal cords had been transected. Thirty-seven neurons in Rexed lamina V responding to ...

✓ The somatosensory cortical evoked response following tibial nerve stimulation was recorded for 4 hours in cats sustaining 100, 300, and 500 gm-cm impact injuries to the posterior thoracic, posterior cervical, and anterior cervical spinal cord. The return of the ...

... and Acceleration of Dorsal-horn Unit Activity by Nitrous Oxide: A Statistical Analysis Arthur Taub, MD ... Besson JM, Conseiller С, Hamann KF, et al: Modifications of dorsal hom cell activities in the ... Duly PN, Wall PD, Webster KE: Cells of origin of the spinothalamic tract in cat and rat ...

Using extracellular single-unit recording techniques, effects of intravenously administered lidocaine on dorsal-horn nociceptive neurons were studied in cats made decerebrate whose spinal cords had been transected. Thirty-seven neurons in Rexed lamina V responding to ...

Using an extracellular microelectrode recording technique, the effects of intravenously administered morphine sulfate upon the single-unit activities of cells in Rexed lamina VII of the lumbar spinal cord were studied in cats following decerebration and spinal cord transection at L1. These neurons responded principally to high-threshold mechanical and thermal stimuli applied to a receptive field in the ipsilateral hind limbs. Morphine sulfate, 0.25, 0.5, and 1.0 mg/kg, caused dose-related suppression of the spontaneous activities of these neurons. The firing rates at maximum suppression, observed 5-10 min after administration of morphine, were 63.9 +/- 9.2 (mean +/- 1 SE), 43.0 +/- 5.4, and 26.5 +/- 6.0 per cent of the control values, respectively. Since these cells have been shown by others to be associated with the spinothalamic and spinoreticular pathways, the results suggest that the analgesic state may result from the action of morphine on the cells of origin of these major ascending pathways in the spinal cord.

... Kitahata, Luke MMD, Ph.D.; McAllister, Roseanne GMD; Taub, Arthur MD, Ph.D. Collapse Box Abstract. ... Central trigeminal nociceptors were identified in the magnocellularis portion of the dorsal horn of the first cervical segment of the spinal cord. ...

Anatomic, physiologic and behavioral evidence suggests that the neurons in the nucleus reticularis gigantocellularis of the medial medullary reticular formation may act as a relay station for the transmission of nociceptive information from the spinal cord to higher brain centers. The nucleus reticularis gigantocellularis may also be the site of action of analgesic agents, such as ketamine hydrochloride. Utilizing extracellular microelectrodes in 23 decerebrate cats, the authors measured the effect of ketamine on neurons in the nucleus reticularis gigantocellularis that were excited by electrical stimulation of peripheral nerves. The frequency of spontaneous single-unit firing activity in the nucleus reticularis gigantocellularis was suppressed by 31 +/- 11 (mean +/- 1 SE) and by 62 +/- 7 per cent with ketamine, 1.0 and 2.5 mg/kg, iv, respectively. The frequency of evoked single-unit activity was suppressed by 57 +/- 9 and 79 +/- 5 per cent with ketamine, 1.0 and 2.5 mg/kg, respectively. Ketamine produces significant depression of single-unit activity of the cells in the nucleus reticularis gigantocellularis, suggesting that this may be an important site of its analgesic action.

The effects of ketamine hydrochloride on single-unit activities of various dorsal-horn Rexed laminae were studied with an extracellular microelectrode recording technique in decerebrate spinal cats. Ketamine hydrochloride, 2.5 mg/kg, iv, suppressed spontaneous single-unit ...

The effects of ketamine hydrochloride on single-unit activities of various dorsal-horn Rexed laminae were studied with an extracellular microelectrode recording technique in decerebrate spinal cats. Ketamine hydrochloride, 2.5 mg/kg, iv, suppressed spontaneous single-unit ...

... Online publication date: 1-Aug-2007. Irene Tracey, Patrick W. Mantyh. (2007) The Cerebral Signature for Pain Perception and Its Modulation. ... T. Zenz, M. Zenz, M. Tryba. (1994) Schmerztherapie bei Herpes zoster und postzosterischer Neuralgie. Der Schmerz 8:1, 24-36. ...

... No highlighting Reflect Reflect highlight proteins and chemicals. Abstract. Abstract - selected. References. References - selected. Experimental Neurology Volume 10, Issue 4, October 1964, Pages 357-374. ... 194: 1-74. 4. ARMFTT, JC, JAB GRAY, and JF PALMER. 1961. ...