The mixed ligand Zn(II), Zr(IV), Pd(II), Ce(IV), Th(IV), and U(VI) complexes of gemifloxacin and ... more The mixed ligand Zn(II), Zr(IV), Pd(II), Ce(IV), Th(IV), and U(VI) complexes of gemifloxacin and N-donor 2,2 0-bipyridine have been prepared. These complexes have been characterized by elemental, infrared (IR), ultraviolet–visible (UV–Vis), 1 H nuclear magnetic resonance (NMR), mass spectroscopy, thermal, molar conductance and magnetic susceptibility analyses. The infrared spectra indicate that gemifloxacin acts as a bidentate deprotonated ligand bound to the metal through the pyridone oxygen and one carboxylate oxygen, whereas the 2,2 0-bipyr-idine coordinates through the two nitrogen atoms. The central metal in each complex is six-coordinate and a slightly distorted octahedral geometry is proposed. The calculated bond length and force constant, F(U=O), in the uranyl complex are 1.751 A ˚ and 641.04 N m-1 , respectively. The thermodynamic parameters are calculated from the thermal analysis curves using the Coats–Redfern and Horowitz– Metzger methods. The antibacterial and antifungal activities of the ligand, metal salt and metal complexes have been tested. The data show that the complexes exhibit significant action against some of the four bacterial species but no effect on two species of fungi compared with gemifloxacin. The antitumor activity of the ligands and their complexes has been evaluated against breast (MCF-7) and colon (HCT-116) cancer cells. Keywords Gemifloxacin Á 2,2 0-Bipyridine Á 1 H NMR Á Thermal Á Cytotoxicity Electronic supplementary material The online version of this article (
ABSTRACT ABSTRACT. The interaction of titanium (IV), yttrium (III), zirconium (IV), palladium (II... more ABSTRACT ABSTRACT. The interaction of titanium (IV), yttrium (III), zirconium (IV), palladium (II) and cerium (IV) with deprotonated enrofloxacin leads to the formation of the neutral or cationic mononuclear complexes. The isolated solid complexes have been characterized with physicochemical and spectroscopic techniques and thermogravimeteric analyses. The spectroscopic data indicate that the enrofloxacin ligand is on the deprotonated mode acting as bidentate ligand coordinated to the metal ions through the ketone oxygen and a carboxylato oxygen and the metal ions completed the coordination number with water molecules. The thermal decomposition mechanisms proposed for enrofloxacin and their metal complexes were discussed. The activation energies, E * , enthalpies, ΔH * , entropies, ΔS * and Gibbs free energies, ΔG * , of the thermal decomposition reactions have been derived from thermogravimetric (TG) and differential thermogravimetric (DTG) curves, using Coats-Redfern (CR) and Horowitz-Metzeger (HM) methods. The antimicrobial activity has been evaluated against six different microorganisms.
Abstract The synthesis and characterization of the new solid complexes [VO (MOX) 2 H 2 O] SO 4· 1... more Abstract The synthesis and characterization of the new solid complexes [VO (MOX) 2 H 2 O] SO 4· 11H 2 O,[ZrO (MOX) 2 Cl] Cl· 15H 2 O and [UO 2 (MOX) 3](NO 3) 2· 3H 2 O formed in the interaction of moxifloxacin (MOX) with VOSO 4· H 2 O, ZrOCl 2· 8H 2 O and UO 2 (NO ...
... an absorption band from 516570 nm which can be assigned to the ligand-to-metal charge transf... more ... an absorption band from 516570 nm which can be assigned to the ligand-to-metal charge transfer transition for the quinolone ligand, as observed in a series of other quinolone complexes 77. Sultana, N, Naz, A, Arayne ... Muhammad, I, Javed, I, Shahid, I and Nazia, I. 2007. Turk. ...
... DOI: 10.1080/00958972.2011.654203 Wael A. Zordok a , Sadeek A. Sadeek a * & Walaa H. ... more ... DOI: 10.1080/00958972.2011.654203 Wael A. Zordok a , Sadeek A. Sadeek a * & Walaa H. El-Shwiniy a pages 353-369. ... View all references and Y–O16, Y–O18 (2.374 Å, 2.407 Å) 6969. Andrews, PC, Beck, T, Fraser, BH, Junk, PC and Massi, M. 2007. ...
A new solid complexes of Ti(IV), Y(III) and Ce(IV) have been synthesized with ofloxacin. The form... more A new solid complexes of Ti(IV), Y(III) and Ce(IV) have been synthesized with ofloxacin. The formulae and structure of the complexes have been proposed in the light of analytical, spectral (1 H NMR, IR and UV-Visible), magnetic, molar conductivities and thermal studies. The complexes are soluble in DMSO-d6 and DMF. The measured molar conduc-tance values indicate that, the three complexes are electrolyte in nature. The results support the formation of the complexes and indicated that ofloxacin reacts as a bidentate ligand chelate to the metal ion through the pyridone oxygen and one carboxylato oxygen. The kinetic parameters of thermogravimetric and its differential have been evaluated by using Coats Redfern (CR) and Horowitz-Metzeger (HM) methods. The thermodynamic data reflect the thermal stability for all complexes. The metal-ligand binding of the Ti(IV), Y(III) and Ce(IV) complexes is predicted using density funcational theory at the B3LYP-CEP-31G level of theory and total energy, dipole moment estimation of different Ti(IV), Y(III) and Ce(IV) ofloxacin structures. The biological activities of the ofloxacin, inorganic salts and their metal complexes were assayed against different bacterial species.
Three metal complexes of the fourth generation quinolone antimicrobial agent gatifloxacin (GFLX) ... more Three metal complexes of the fourth generation quinolone antimicrobial agent gatifloxacin (GFLX) with Y(III), Zr(IV) and U(VI) have been prepared and characterized with physicochemical and spectroscopic techniques. In these complexes, gatifloxacin acts as a bidentate deprotonated ligand bound to the metal through the ketone oxygen and a carboxylato oxygen. The complexes are six-coordinated with distorted octahedral geometry. The kinetic parameters for gatifloxacin and the three prepared complexes have been evaluated from TGA curves by using Coats–Redfern (CR) and Horowitz–Metzeger (HM) methods. The calculated bond length and force constant, F(U@O), for the UO 2 bond in uranyl complex are 1.7522 Å and 639.46 N m À1. The antimicrobial activity of the complexes has been tested against microorganisms, three bacterial species, such as Staphylococcus aureus (S. aureus), Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) and two fungi species, penicillium (P. rotatum) and trichoderma (T. sp.), showing that they exhibit higher activity than free ligand.
Two new norfloxacin complexes were prepared from the interaction of Zr(ΙV) and U(VΙ) with norflox... more Two new norfloxacin complexes were prepared from the interaction of Zr(ΙV) and U(VΙ) with norfloxacin (NOR) in methanol and acetone, at room temperature and separated as solids with characteristic colors. Elemental analysis, infrared and UV-Vis spectroscopy, conductance measurements, 1 HNMR and thermal analyses have been used to characterize the isolated solid complexes. The results support the formation of the complexes with the formula [ZrO(NOR) 2 Cl]Cl.15H 2 O and [UO 2 (NOR) 3 ](NO 3) 2 .4H 2 O. The infrared spectra of the isolated solid complexes suggested that the norfloxacin react as bidentate ligand through the carbonyl oxygen atom and one oxygen atom of the carboxylic group forming six atoms rings with the metal ions. The bond stretching force constant and length of the U=O bond for the [UO 2 (NOR) 3 ](NO 3) 2 .4H 2 O complex were
Two new complexes were prepared from the interaction of Y(ΙΙΙ) and Pd(ΙΙ) with norfloxacin (NOR) ... more Two new complexes were prepared from the interaction of Y(ΙΙΙ) and Pd(ΙΙ) with norfloxacin (NOR) in ethanol and diethyl ether at room temperature and separated as solids with characteristic colors. The infrared spectra were obtained and full assignment of all the observed vibrations is proposed which indicate that the norfloxacin react as bidentate ligand through the carbonyl oxygen atom and one of oxygen atoms of the carboxylate group forming six membered rings with the metal ions. The complexes were characterized by using 1 HNMR and UV-vis spectroscopies, as well as thermal analysis. The activation energies, E * , entropies, ΔS * , enthalpies, ΔH * and Gibbs free energies, ΔG * , of the thermal decomposition reactions have been derived from thermogravimetric (TGA) and differential thermogravimetric (DrTGA) curves, using Coats-Redfern and Horowitz-Metzger methods. The proposed structure of the two complexes were detected by using the Density Functional Theory (DFT) at the B3LYP/CEP-31G level of theory. The ligand as well as their metal complexes were also evaluated for their antibacterial activity against several bacterial species, such as Staphylococcus aureus (S. aureus), Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) and antifungal screening was studied against two species: penicillium (P. rotatum) and
The mixed ligand Zn(II), Zr(IV), Pd(II), Ce(IV), Th(IV), and U(VI) complexes of gemifloxacin and ... more The mixed ligand Zn(II), Zr(IV), Pd(II), Ce(IV), Th(IV), and U(VI) complexes of gemifloxacin and N-donor 2,2 0-bipyridine have been prepared. These complexes have been characterized by elemental, infrared (IR), ultraviolet–visible (UV–Vis), 1 H nuclear magnetic resonance (NMR), mass spectroscopy, thermal, molar conductance and magnetic susceptibility analyses. The infrared spectra indicate that gemifloxacin acts as a bidentate deprotonated ligand bound to the metal through the pyridone oxygen and one carboxylate oxygen, whereas the 2,2 0-bipyr-idine coordinates through the two nitrogen atoms. The central metal in each complex is six-coordinate and a slightly distorted octahedral geometry is proposed. The calculated bond length and force constant, F(U=O), in the uranyl complex are 1.751 A ˚ and 641.04 N m-1 , respectively. The thermodynamic parameters are calculated from the thermal analysis curves using the Coats–Redfern and Horowitz– Metzger methods. The antibacterial and antifungal activities of the ligand, metal salt and metal complexes have been tested. The data show that the complexes exhibit significant action against some of the four bacterial species but no effect on two species of fungi compared with gemifloxacin. The antitumor activity of the ligands and their complexes has been evaluated against breast (MCF-7) and colon (HCT-116) cancer cells. Keywords Gemifloxacin Á 2,2 0-Bipyridine Á 1 H NMR Á Thermal Á Cytotoxicity Electronic supplementary material The online version of this article (
Six new complexes of Cthta were synthesized and characterized. The complexes were characterized b... more Six new complexes of Cthta were synthesized and characterized. The complexes were characterized by using spectroscopic methods. The antimicrobial activities of Cthta and its metal complexes were evaluated. g r a p h i c a l a b s t r a c t The synthesis, the characterization and the antibacterial activity of the neutral mononuclear V(IV), Zr(IV), Pd(II), Pt(IV), Ce(IV) and U(VI) complexes with the 2-Cyano-2-(p-tolyl-hydrazono)-thioacetamide (Cthta) are presented. a b s t r a c t 2-Cyano-2-(p-tolyl-hydrazono)-thioacetamide (Cthta) reacted with V(IV), Zr(IV), Pd(II), Pt(IV), Ce(IV) and U(VI) in acetone as a solvent at room temperature to form a solid complexes with characteristic color for metal ion. The molar ratio for all synthesized complexes is M:Cthta = 1:2 which was established from the results of chemical analysis. The isolated complexes have been characterized with their melting points, elemental analysis , magnetic properties, conductance measurements, mass, IR, UV–Vis. and 1 H NMR spectroscopic methods and thermal analyses. The results supported the formation of the complexes and indicated that the Cthta reacts as a bidentate ligand. The thermogravimetric and infrared spectroscopic data confirmed the presence of water in the composition of the complexes. The molar conductance values of all complexes in (DMSO) were found in the range 150.71–328.85 S cm 2 mol À1 at room temperature. The magnetic moments of the complexes were measured at room temperature. The kinetic parameters of thermogravimetric and its differential have been evaluated by using Coats Redfern (CR) and Horowitz–Metzeger (HM) methods. The ligand as well as their metal complexes were also evaluated for their antibacterial and antifungal activities.
The mixed ligand Zn(II), Zr(IV), Pd(II), Ce(IV), Th(IV), and U(VI) complexes of gemifloxacin and ... more The mixed ligand Zn(II), Zr(IV), Pd(II), Ce(IV), Th(IV), and U(VI) complexes of gemifloxacin and N-donor 2,2 0-bipyridine have been prepared. These complexes have been characterized by elemental, infrared (IR), ultraviolet–visible (UV–Vis), 1 H nuclear magnetic resonance (NMR), mass spectroscopy, thermal, molar conductance and magnetic susceptibility analyses. The infrared spectra indicate that gemifloxacin acts as a bidentate deprotonated ligand bound to the metal through the pyridone oxygen and one carboxylate oxygen, whereas the 2,2 0-bipyr-idine coordinates through the two nitrogen atoms. The central metal in each complex is six-coordinate and a slightly distorted octahedral geometry is proposed. The calculated bond length and force constant, F(U=O), in the uranyl complex are 1.751 A ˚ and 641.04 N m-1 , respectively. The thermodynamic parameters are calculated from the thermal analysis curves using the Coats–Redfern and Horowitz– Metzger methods. The antibacterial and antifungal activities of the ligand, metal salt and metal complexes have been tested. The data show that the complexes exhibit significant action against some of the four bacterial species but no effect on two species of fungi compared with gemifloxacin. The antitumor activity of the ligands and their complexes has been evaluated against breast (MCF-7) and colon (HCT-116) cancer cells. Keywords Gemifloxacin Á 2,2 0-Bipyridine Á 1 H NMR Á Thermal Á Cytotoxicity Electronic supplementary material The online version of this article (
ABSTRACT ABSTRACT. The interaction of titanium (IV), yttrium (III), zirconium (IV), palladium (II... more ABSTRACT ABSTRACT. The interaction of titanium (IV), yttrium (III), zirconium (IV), palladium (II) and cerium (IV) with deprotonated enrofloxacin leads to the formation of the neutral or cationic mononuclear complexes. The isolated solid complexes have been characterized with physicochemical and spectroscopic techniques and thermogravimeteric analyses. The spectroscopic data indicate that the enrofloxacin ligand is on the deprotonated mode acting as bidentate ligand coordinated to the metal ions through the ketone oxygen and a carboxylato oxygen and the metal ions completed the coordination number with water molecules. The thermal decomposition mechanisms proposed for enrofloxacin and their metal complexes were discussed. The activation energies, E * , enthalpies, ΔH * , entropies, ΔS * and Gibbs free energies, ΔG * , of the thermal decomposition reactions have been derived from thermogravimetric (TG) and differential thermogravimetric (DTG) curves, using Coats-Redfern (CR) and Horowitz-Metzeger (HM) methods. The antimicrobial activity has been evaluated against six different microorganisms.
Abstract The synthesis and characterization of the new solid complexes [VO (MOX) 2 H 2 O] SO 4· 1... more Abstract The synthesis and characterization of the new solid complexes [VO (MOX) 2 H 2 O] SO 4· 11H 2 O,[ZrO (MOX) 2 Cl] Cl· 15H 2 O and [UO 2 (MOX) 3](NO 3) 2· 3H 2 O formed in the interaction of moxifloxacin (MOX) with VOSO 4· H 2 O, ZrOCl 2· 8H 2 O and UO 2 (NO ...
... an absorption band from 516570 nm which can be assigned to the ligand-to-metal charge transf... more ... an absorption band from 516570 nm which can be assigned to the ligand-to-metal charge transfer transition for the quinolone ligand, as observed in a series of other quinolone complexes 77. Sultana, N, Naz, A, Arayne ... Muhammad, I, Javed, I, Shahid, I and Nazia, I. 2007. Turk. ...
... DOI: 10.1080/00958972.2011.654203 Wael A. Zordok a , Sadeek A. Sadeek a * & Walaa H. ... more ... DOI: 10.1080/00958972.2011.654203 Wael A. Zordok a , Sadeek A. Sadeek a * & Walaa H. El-Shwiniy a pages 353-369. ... View all references and Y–O16, Y–O18 (2.374 Å, 2.407 Å) 6969. Andrews, PC, Beck, T, Fraser, BH, Junk, PC and Massi, M. 2007. ...
A new solid complexes of Ti(IV), Y(III) and Ce(IV) have been synthesized with ofloxacin. The form... more A new solid complexes of Ti(IV), Y(III) and Ce(IV) have been synthesized with ofloxacin. The formulae and structure of the complexes have been proposed in the light of analytical, spectral (1 H NMR, IR and UV-Visible), magnetic, molar conductivities and thermal studies. The complexes are soluble in DMSO-d6 and DMF. The measured molar conduc-tance values indicate that, the three complexes are electrolyte in nature. The results support the formation of the complexes and indicated that ofloxacin reacts as a bidentate ligand chelate to the metal ion through the pyridone oxygen and one carboxylato oxygen. The kinetic parameters of thermogravimetric and its differential have been evaluated by using Coats Redfern (CR) and Horowitz-Metzeger (HM) methods. The thermodynamic data reflect the thermal stability for all complexes. The metal-ligand binding of the Ti(IV), Y(III) and Ce(IV) complexes is predicted using density funcational theory at the B3LYP-CEP-31G level of theory and total energy, dipole moment estimation of different Ti(IV), Y(III) and Ce(IV) ofloxacin structures. The biological activities of the ofloxacin, inorganic salts and their metal complexes were assayed against different bacterial species.
Three metal complexes of the fourth generation quinolone antimicrobial agent gatifloxacin (GFLX) ... more Three metal complexes of the fourth generation quinolone antimicrobial agent gatifloxacin (GFLX) with Y(III), Zr(IV) and U(VI) have been prepared and characterized with physicochemical and spectroscopic techniques. In these complexes, gatifloxacin acts as a bidentate deprotonated ligand bound to the metal through the ketone oxygen and a carboxylato oxygen. The complexes are six-coordinated with distorted octahedral geometry. The kinetic parameters for gatifloxacin and the three prepared complexes have been evaluated from TGA curves by using Coats–Redfern (CR) and Horowitz–Metzeger (HM) methods. The calculated bond length and force constant, F(U@O), for the UO 2 bond in uranyl complex are 1.7522 Å and 639.46 N m À1. The antimicrobial activity of the complexes has been tested against microorganisms, three bacterial species, such as Staphylococcus aureus (S. aureus), Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) and two fungi species, penicillium (P. rotatum) and trichoderma (T. sp.), showing that they exhibit higher activity than free ligand.
Two new norfloxacin complexes were prepared from the interaction of Zr(ΙV) and U(VΙ) with norflox... more Two new norfloxacin complexes were prepared from the interaction of Zr(ΙV) and U(VΙ) with norfloxacin (NOR) in methanol and acetone, at room temperature and separated as solids with characteristic colors. Elemental analysis, infrared and UV-Vis spectroscopy, conductance measurements, 1 HNMR and thermal analyses have been used to characterize the isolated solid complexes. The results support the formation of the complexes with the formula [ZrO(NOR) 2 Cl]Cl.15H 2 O and [UO 2 (NOR) 3 ](NO 3) 2 .4H 2 O. The infrared spectra of the isolated solid complexes suggested that the norfloxacin react as bidentate ligand through the carbonyl oxygen atom and one oxygen atom of the carboxylic group forming six atoms rings with the metal ions. The bond stretching force constant and length of the U=O bond for the [UO 2 (NOR) 3 ](NO 3) 2 .4H 2 O complex were
Two new complexes were prepared from the interaction of Y(ΙΙΙ) and Pd(ΙΙ) with norfloxacin (NOR) ... more Two new complexes were prepared from the interaction of Y(ΙΙΙ) and Pd(ΙΙ) with norfloxacin (NOR) in ethanol and diethyl ether at room temperature and separated as solids with characteristic colors. The infrared spectra were obtained and full assignment of all the observed vibrations is proposed which indicate that the norfloxacin react as bidentate ligand through the carbonyl oxygen atom and one of oxygen atoms of the carboxylate group forming six membered rings with the metal ions. The complexes were characterized by using 1 HNMR and UV-vis spectroscopies, as well as thermal analysis. The activation energies, E * , entropies, ΔS * , enthalpies, ΔH * and Gibbs free energies, ΔG * , of the thermal decomposition reactions have been derived from thermogravimetric (TGA) and differential thermogravimetric (DrTGA) curves, using Coats-Redfern and Horowitz-Metzger methods. The proposed structure of the two complexes were detected by using the Density Functional Theory (DFT) at the B3LYP/CEP-31G level of theory. The ligand as well as their metal complexes were also evaluated for their antibacterial activity against several bacterial species, such as Staphylococcus aureus (S. aureus), Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) and antifungal screening was studied against two species: penicillium (P. rotatum) and
The mixed ligand Zn(II), Zr(IV), Pd(II), Ce(IV), Th(IV), and U(VI) complexes of gemifloxacin and ... more The mixed ligand Zn(II), Zr(IV), Pd(II), Ce(IV), Th(IV), and U(VI) complexes of gemifloxacin and N-donor 2,2 0-bipyridine have been prepared. These complexes have been characterized by elemental, infrared (IR), ultraviolet–visible (UV–Vis), 1 H nuclear magnetic resonance (NMR), mass spectroscopy, thermal, molar conductance and magnetic susceptibility analyses. The infrared spectra indicate that gemifloxacin acts as a bidentate deprotonated ligand bound to the metal through the pyridone oxygen and one carboxylate oxygen, whereas the 2,2 0-bipyr-idine coordinates through the two nitrogen atoms. The central metal in each complex is six-coordinate and a slightly distorted octahedral geometry is proposed. The calculated bond length and force constant, F(U=O), in the uranyl complex are 1.751 A ˚ and 641.04 N m-1 , respectively. The thermodynamic parameters are calculated from the thermal analysis curves using the Coats–Redfern and Horowitz– Metzger methods. The antibacterial and antifungal activities of the ligand, metal salt and metal complexes have been tested. The data show that the complexes exhibit significant action against some of the four bacterial species but no effect on two species of fungi compared with gemifloxacin. The antitumor activity of the ligands and their complexes has been evaluated against breast (MCF-7) and colon (HCT-116) cancer cells. Keywords Gemifloxacin Á 2,2 0-Bipyridine Á 1 H NMR Á Thermal Á Cytotoxicity Electronic supplementary material The online version of this article (
Six new complexes of Cthta were synthesized and characterized. The complexes were characterized b... more Six new complexes of Cthta were synthesized and characterized. The complexes were characterized by using spectroscopic methods. The antimicrobial activities of Cthta and its metal complexes were evaluated. g r a p h i c a l a b s t r a c t The synthesis, the characterization and the antibacterial activity of the neutral mononuclear V(IV), Zr(IV), Pd(II), Pt(IV), Ce(IV) and U(VI) complexes with the 2-Cyano-2-(p-tolyl-hydrazono)-thioacetamide (Cthta) are presented. a b s t r a c t 2-Cyano-2-(p-tolyl-hydrazono)-thioacetamide (Cthta) reacted with V(IV), Zr(IV), Pd(II), Pt(IV), Ce(IV) and U(VI) in acetone as a solvent at room temperature to form a solid complexes with characteristic color for metal ion. The molar ratio for all synthesized complexes is M:Cthta = 1:2 which was established from the results of chemical analysis. The isolated complexes have been characterized with their melting points, elemental analysis , magnetic properties, conductance measurements, mass, IR, UV–Vis. and 1 H NMR spectroscopic methods and thermal analyses. The results supported the formation of the complexes and indicated that the Cthta reacts as a bidentate ligand. The thermogravimetric and infrared spectroscopic data confirmed the presence of water in the composition of the complexes. The molar conductance values of all complexes in (DMSO) were found in the range 150.71–328.85 S cm 2 mol À1 at room temperature. The magnetic moments of the complexes were measured at room temperature. The kinetic parameters of thermogravimetric and its differential have been evaluated by using Coats Redfern (CR) and Horowitz–Metzeger (HM) methods. The ligand as well as their metal complexes were also evaluated for their antibacterial and antifungal activities.
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