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- Gelsemine (C20H22N2O2) is an indole alkaloid isolated from flowering plants of the genus Gelsemium, a plant native to the subtropical and tropical Americas, and southeast Asia, and is a highly toxic compound that acts as a paralytic, exposure to which can result in death. It has generally potent activity as an agonist of the mammalian glycine receptor, the activation of which leads to an inhibitory postsynaptic potential in neurons following chloride ion influx, and systemically, to muscle relaxation of varying intensity and deleterious effect. Despite its danger and toxicity, recent pharmacological research has suggested that the biological activities of this compound may offer opportunities for developing treatments related to xenobiotic or diet-induced oxidative stress, and of anxiety and other conditions, with ongoing research including attempts to identify safer derivatives and analogs to make use of gelsemine's beneficial effects. (en)
- Gelsemina es un alcaloide tóxico encontrado en la planta Gelsemium sempervirens. Tiene efectos convulsivos con un mecanismo de acción similar a la estricnina. Debido a su estructura compleja, gelsemina ha sido el objetivo de un número de proyectos de síntesis total. (es)
- 钩吻碱（C20H22N2O2）是一种吲哚生物碱，分离自原产于热带和亚热带美洲和东南亚的开花植物钩吻属。是一种麻痹剧毒化合物，接触可导致死亡。通常具有作为哺乳动物甘氨酸受体激动剂的有效活性，其活化导致氯离子流入后神经元中的抑制突触后电位，并且导致全身性的不同强度的有害肌肉松弛。尽管其存在危险和毒性，但最近的药理学研究表明，该化合物的生物活性可能为开发异生素或饮食诱导的氧化应激，焦虑和其他疾病相关的治疗提供机会，正在进行的研究包括尝试识别更安全衍生物和类似物，以利用钩吻碱的有益效果。 (zh)
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- Gelsemine , an indole alkaloid (en)
- secologanin (en)
- tryptamine (en)
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- Strictosidine and its precursors, line-angle representations. 3α-strictosidine is a key intermediate on the biosynthetic pathway of gelsemine, and it is the common precursor for essentially all monoterpenoid indole alkaloids. Strictosidine is derived in one enzyme-catalyzed step from tryptamine and secologanin . (en)
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- Secologanin.png (en)
- Strictosidine.svg (en)
- Tryptamine.svg (en)
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- CN1C[C@@H]4[C@]5[C@H]3C[C@H]2[C@]4C1 (en)
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- Gelsemina es un alcaloide tóxico encontrado en la planta Gelsemium sempervirens. Tiene efectos convulsivos con un mecanismo de acción similar a la estricnina. Debido a su estructura compleja, gelsemina ha sido el objetivo de un número de proyectos de síntesis total. (es)
- 钩吻碱（C20H22N2O2）是一种吲哚生物碱，分离自原产于热带和亚热带美洲和东南亚的开花植物钩吻属。是一种麻痹剧毒化合物，接触可导致死亡。通常具有作为哺乳动物甘氨酸受体激动剂的有效活性，其活化导致氯离子流入后神经元中的抑制突触后电位，并且导致全身性的不同强度的有害肌肉松弛。尽管其存在危险和毒性，但最近的药理学研究表明，该化合物的生物活性可能为开发异生素或饮食诱导的氧化应激，焦虑和其他疾病相关的治疗提供机会，正在进行的研究包括尝试识别更安全衍生物和类似物，以利用钩吻碱的有益效果。 (zh)
- Gelsemine (C20H22N2O2) is an indole alkaloid isolated from flowering plants of the genus Gelsemium, a plant native to the subtropical and tropical Americas, and southeast Asia, and is a highly toxic compound that acts as a paralytic, exposure to which can result in death. It has generally potent activity as an agonist of the mammalian glycine receptor, the activation of which leads to an inhibitory postsynaptic potential in neurons following chloride ion influx, and systemically, to muscle relaxation of varying intensity and deleterious effect. Despite its danger and toxicity, recent pharmacological research has suggested that the biological activities of this compound may offer opportunities for developing treatments related to xenobiotic or diet-induced oxidative stress, and of anxiety a (en)
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- Gelsemina (es)
- Gelsemine (en)
- 钩吻碱 (zh)
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