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Structural biology

Piston drives a proton pump

Nature volume 465, pages 428–429 (2010)Cite this article

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The membrane-spanning enzyme known as complex I couples the movement of electrons to that of protons as a way of converting energy. Crystal structures suggest how electron transfer drives proton pumping from afar.

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Figure 1: Indirect coupling of electron transfer to proton pumping in complex I.

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  1. Department of Biochemistry and Biophysics, Tomoko Ohnishi is in the Johnson Foundation, School of Medicine, University of Pennsylvania, Pennsylvania 19104, USA. ohnishi@mail.med.upenn.edu,

    Tomoko Ohnishi

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Ohnishi, T. Piston drives a proton pump. Nature 465, 428–429 (2010). https://doi.org/10.1038/465428a

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