Background: Dibru-Saikhowa National Park and Biosphere Reserve (DSNPBR), Assam, India, is a part ... more Background: Dibru-Saikhowa National Park and Biosphere Reserve (DSNPBR), Assam, India, is a part of biodiversity hotspots and a store house of many orchid species. This systematic review was conducted to document the medicinal importante of orchids available in DSNPBR and to analyse their importance in drug discovery. Methods: This systematic review was conducted using the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Scientific databases were used to search relevant literature to document ethnomedicinal uses, pharmacological activity and phytochemistry of orchid species available in DSNPBR. Results: We have analysed 84 articles to document relevant information on 52 orchid species available in DSNPBR. Dendrobium (n=13) is the top genus. Different orchid species available in DSNPBR were used traditionally in India, Nepal, Bangladesh, and China to cure gastrointestinal disorders, disease-associated pain and inflammation, skin diseases, wound, ...
: Flavonoids are important bioactive phenolic compounds abundant in plants and exhibit different ... more : Flavonoids are important bioactive phenolic compounds abundant in plants and exhibit different therapeutic potentials. A wound is a significant problem in diabetic individuals. A hyper-glycaemic environment alters the normal wound-healing process and increases the risk of microbial infection, leading to hospitalization, morbidity, and amputation. Flavonoids are an important class of phytochemicals with excellent antioxidant, anti-inflammatory, antimicrobial, antidiabetic, anti-tumor, and wound healing property. Quercetin, hesperidin, curcumin, kaempferol, apigenin, luteo-lin, morin, etc. have shown their wound healing potential. Flavonoids effectively exhibit antimicro-bial activity, scavenge reactive oxygen species, augment endogenous antioxidants, reduce the ex-pression and synthesis of inflammatory cytokines (i.e. IL-1β, IL-6, TNF-α, NF-κB), inhibit inflam-matory enzymes, enhance anti-inflammatory cytokine (IL-10), enhance insulin section, reduce insu-lin resistance, and control blood glucose level. Several flavonoids like hesperidin, curcumin, quer-cetin, rutin, naringin, and luteolin have shown their potential in managing diabetic wounds. Natural products that maintain glucose haemostatic, exert anti-inflammatory activity, suppress/inhibit mi-crobial growth, modulate cytokines, inhibit matrix metalloproteinase (MMP), stimulate angiogene-sis and extracellular matrix, and modulate growth factor can be considered as a potential therapeutic lead to treat diabetic wound. Flavonoids were found to play a positive role in management of dia-betic wounds by regulating MMP-2, MMP-8, MMP-9, MMP-13, Ras/Raf/ MEK/ERK, PI3K/Akt, and nitric oxide pathways. Therefore, it can be assumed that flavonoids could be potential therapeu-tics to prevent devastating effects of diabetic wounds. This paper focused on the potential role of flavonoids in managing diabetic wounds and discussed their possible mechanism of action.
Non-steroidal anti-inflammatory drugs (NSAIDs) are often used to treat fever and pain. Apart from... more Non-steroidal anti-inflammatory drugs (NSAIDs) are often used to treat fever and pain. Apart from its medicinal benefits, it is also well known for its numerous side effects, including myocardial infarction, gastrointestinal haemorrhage, renal failure, etc. Even beside these side effects NSAIDs are believed to play a major role in cancer. Though there are contrary of being inducing or preventive reason for cancer. Many studies shows NSAIDs are associated with the increasing risk of cancer. While as in various studies these drugs also have been investigated for their anti-cancer property as chronic inflammation has direct association with carcinogenesis. This review enlights the role of NSAIDs in cancer promotion and cancer prevention, connection between chronic inflammation and cancer, and some of the potentially lethal side effects of these drugs.
Assam is a state in Indias north-eastern region, known for its lush floral and cultural diversity... more Assam is a state in Indias north-eastern region, known for its lush floral and cultural diversity. We combed through the literature and discovered that about 117 Assamese plant species had been shown to have antidiabetic potential in preclinical studies. Diabetes, in its many forms, has been a long-standing problem for doctors for decades. Many aspects of diabetes must be investigated, including the physiological actions of insulin and the different clinical features of the condition, such as tissue complications. Since diabetes is a lifestyle disease, careful care with regard to diet and anti-diabetic agents is essential. Herbal diabetes therapy is not a novel concept. Plants and plant extracts have been used to treat diabetes since 1550 B.C., with as many as 400 prescribed before the development of effective diabetes drugs earlier this century.
In most recent couple of a few years, there has been a unprecedented advancement in understanding... more In most recent couple of a few years, there has been a unprecedented advancement in understanding the biochemical and cell occasions of typical injury recuperating or wound healing. Healing is survival mechanism and represents a trial to take care of normal complex body part and performance.Wound healing could be a process by which tissue regeneration occurs. Healing of wounds, either accidental or surgical interventions, involves complex activities of blood cells, tissues, soluble mediators, cytokines and several other growth factors. This increased cellular activity of damaged tissue enhances metabolic demands and active drug therapy. The main objective of treating a wound is to either shorten the time required for healing process or to reduce the undue effects. Plants because of presence of assorted valuable active phytoconstituents have immense potential for management and treatment of wounds over the years. All the Traditional systems of medicine, Ayurveda, Siddha and Unani des...
International Journal of Applied Pharmaceutics, 2021
Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a s... more Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a significant public health issue. Global shortages of medical products have a potential effect on patient health and total healthcare costs. Countries worldwide, especially those affected by Coronavirus disease 2019 (COVID-19), is experiencing a rapid increase in drug shortage, which causes several complications for physicians, health care provider, patients, health institutes and health regulatory bodies. Methods: To carry out the study of shortages, several efforts have been taken by the regulators and industries. Prominent amongst these include FDA's research the needs and the reforms made in the regulations about shortages. We also searched for electronic databases (PubMed, Science direct, Web of Science) using the terms (COVID-19 and shortage) or (medicine and COVID-19) for articles in periods of 2019 to 2021. Results: On assessment based on the report, the number of shortage drug...
Journal of Pharmaceutical Research International, 2021
Antibiotics are the class of drugs used for bacterial, viral & fungal infection. Antibiotic resis... more Antibiotics are the class of drugs used for bacterial, viral & fungal infection. Antibiotic resistance is the ability of microorganism to withstand themselves against the effects of a drug. Every year antibiotic resistance causes more than 38000 deaths in Thailand, 23000 deaths in USA. In South Asia one new born child dies every 5 minutes from blood stream infection because antibiotics given are ineffective due to bacterial resistance. Now antibiotic resistance is a threat to global health. In this paper, triazene derivatives are kept in concern. Triazines are six-membered, nitrogen-containing heterocyclic scaffold with a wide range of pharmaceutical properties such as antibacterial, antifungal, anticancer, antioxidants, antitubercular, antimalarial and anti-inflammatory. Due to lack of new antibiotics as well older antibiotic are rapidly proving ineffective, derivatives of triazine would be of great significance in future prospective.
This investigation is based on a very remarkable and interesting orchid of the genus Dendrobium w... more This investigation is based on a very remarkable and interesting orchid of the genus Dendrobium widely available in Meghalaya (India) and it is the world second largest orchid genus. The purpose of the study was to evaluate the anti-oxidant and anti-pyretic activity of leaf of Dendrobium chrysanthum. As the plants believed traditionally to have some anti-inflammatory activity used by the rural people of Meghalaya, use of medicinal plants and plants extract for the health procurement has always remain a common choice for the North- eastern people of India since ancient time. The leaf of Dendrobium c. was collected from Shillong, Meghalaya and extraction is done by using methanol as a solvent. The methanol extract found to have the constituents such as carbohydrate, glycoside, alkaloids, phenol and flavonoids. Acute anti-pyretic activity for the extract was investigated in pyrexia rat. Temperature level was determined after 1hours, 2 hours, 4 hours and 6 hours after giving the extrac...
Wound healing is a vital physiological process that helps to retain the integrity of the skin aft... more Wound healing is a vital physiological process that helps to retain the integrity of the skin after it has been damaged, whether by accident or by a deliberate operation. In Tinsukia district, Assam, tribal people and folklore traditions employ a wide variety of plants/plant extracts/decoctions or pastes to cure wounds. This study is designed to explore the ethnomedicinal plants used for the wound healing properties by the people of Tinsukia district, Assam. The Documentation of potential ethnobotanical information of traditionally used medicinal plant with wound healing activity will facilitates the scientific evaluation to look forward into a leading scientific prospect for the development of new herbal therapy for wound healing.
Background: Dibru-Saikhowa National Park and Biosphere Reserve (DSNPBR), Assam, India, is a part ... more Background: Dibru-Saikhowa National Park and Biosphere Reserve (DSNPBR), Assam, India, is a part of biodiversity hotspots and a store house of many orchid species. This systematic review was conducted to document the medicinal importante of orchids available in DSNPBR and to analyse their importance in drug discovery. Methods: This systematic review was conducted using the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Scientific databases were used to search relevant literature to document ethnomedicinal uses, pharmacological activity and phytochemistry of orchid species available in DSNPBR. Results: We have analysed 84 articles to document relevant information on 52 orchid species available in DSNPBR. Dendrobium (n=13) is the top genus. Different orchid species available in DSNPBR were used traditionally in India, Nepal, Bangladesh, and China to cure gastrointestinal disorders, disease-associated pain and inflammation, skin diseases, wound, ...
: Flavonoids are important bioactive phenolic compounds abundant in plants and exhibit different ... more : Flavonoids are important bioactive phenolic compounds abundant in plants and exhibit different therapeutic potentials. A wound is a significant problem in diabetic individuals. A hyper-glycaemic environment alters the normal wound-healing process and increases the risk of microbial infection, leading to hospitalization, morbidity, and amputation. Flavonoids are an important class of phytochemicals with excellent antioxidant, anti-inflammatory, antimicrobial, antidiabetic, anti-tumor, and wound healing property. Quercetin, hesperidin, curcumin, kaempferol, apigenin, luteo-lin, morin, etc. have shown their wound healing potential. Flavonoids effectively exhibit antimicro-bial activity, scavenge reactive oxygen species, augment endogenous antioxidants, reduce the ex-pression and synthesis of inflammatory cytokines (i.e. IL-1β, IL-6, TNF-α, NF-κB), inhibit inflam-matory enzymes, enhance anti-inflammatory cytokine (IL-10), enhance insulin section, reduce insu-lin resistance, and control blood glucose level. Several flavonoids like hesperidin, curcumin, quer-cetin, rutin, naringin, and luteolin have shown their potential in managing diabetic wounds. Natural products that maintain glucose haemostatic, exert anti-inflammatory activity, suppress/inhibit mi-crobial growth, modulate cytokines, inhibit matrix metalloproteinase (MMP), stimulate angiogene-sis and extracellular matrix, and modulate growth factor can be considered as a potential therapeutic lead to treat diabetic wound. Flavonoids were found to play a positive role in management of dia-betic wounds by regulating MMP-2, MMP-8, MMP-9, MMP-13, Ras/Raf/ MEK/ERK, PI3K/Akt, and nitric oxide pathways. Therefore, it can be assumed that flavonoids could be potential therapeu-tics to prevent devastating effects of diabetic wounds. This paper focused on the potential role of flavonoids in managing diabetic wounds and discussed their possible mechanism of action.
Non-steroidal anti-inflammatory drugs (NSAIDs) are often used to treat fever and pain. Apart from... more Non-steroidal anti-inflammatory drugs (NSAIDs) are often used to treat fever and pain. Apart from its medicinal benefits, it is also well known for its numerous side effects, including myocardial infarction, gastrointestinal haemorrhage, renal failure, etc. Even beside these side effects NSAIDs are believed to play a major role in cancer. Though there are contrary of being inducing or preventive reason for cancer. Many studies shows NSAIDs are associated with the increasing risk of cancer. While as in various studies these drugs also have been investigated for their anti-cancer property as chronic inflammation has direct association with carcinogenesis. This review enlights the role of NSAIDs in cancer promotion and cancer prevention, connection between chronic inflammation and cancer, and some of the potentially lethal side effects of these drugs.
Assam is a state in Indias north-eastern region, known for its lush floral and cultural diversity... more Assam is a state in Indias north-eastern region, known for its lush floral and cultural diversity. We combed through the literature and discovered that about 117 Assamese plant species had been shown to have antidiabetic potential in preclinical studies. Diabetes, in its many forms, has been a long-standing problem for doctors for decades. Many aspects of diabetes must be investigated, including the physiological actions of insulin and the different clinical features of the condition, such as tissue complications. Since diabetes is a lifestyle disease, careful care with regard to diet and anti-diabetic agents is essential. Herbal diabetes therapy is not a novel concept. Plants and plant extracts have been used to treat diabetes since 1550 B.C., with as many as 400 prescribed before the development of effective diabetes drugs earlier this century.
In most recent couple of a few years, there has been a unprecedented advancement in understanding... more In most recent couple of a few years, there has been a unprecedented advancement in understanding the biochemical and cell occasions of typical injury recuperating or wound healing. Healing is survival mechanism and represents a trial to take care of normal complex body part and performance.Wound healing could be a process by which tissue regeneration occurs. Healing of wounds, either accidental or surgical interventions, involves complex activities of blood cells, tissues, soluble mediators, cytokines and several other growth factors. This increased cellular activity of damaged tissue enhances metabolic demands and active drug therapy. The main objective of treating a wound is to either shorten the time required for healing process or to reduce the undue effects. Plants because of presence of assorted valuable active phytoconstituents have immense potential for management and treatment of wounds over the years. All the Traditional systems of medicine, Ayurveda, Siddha and Unani des...
International Journal of Applied Pharmaceutics, 2021
Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a s... more Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a significant public health issue. Global shortages of medical products have a potential effect on patient health and total healthcare costs. Countries worldwide, especially those affected by Coronavirus disease 2019 (COVID-19), is experiencing a rapid increase in drug shortage, which causes several complications for physicians, health care provider, patients, health institutes and health regulatory bodies. Methods: To carry out the study of shortages, several efforts have been taken by the regulators and industries. Prominent amongst these include FDA's research the needs and the reforms made in the regulations about shortages. We also searched for electronic databases (PubMed, Science direct, Web of Science) using the terms (COVID-19 and shortage) or (medicine and COVID-19) for articles in periods of 2019 to 2021. Results: On assessment based on the report, the number of shortage drug...
Journal of Pharmaceutical Research International, 2021
Antibiotics are the class of drugs used for bacterial, viral & fungal infection. Antibiotic resis... more Antibiotics are the class of drugs used for bacterial, viral & fungal infection. Antibiotic resistance is the ability of microorganism to withstand themselves against the effects of a drug. Every year antibiotic resistance causes more than 38000 deaths in Thailand, 23000 deaths in USA. In South Asia one new born child dies every 5 minutes from blood stream infection because antibiotics given are ineffective due to bacterial resistance. Now antibiotic resistance is a threat to global health. In this paper, triazene derivatives are kept in concern. Triazines are six-membered, nitrogen-containing heterocyclic scaffold with a wide range of pharmaceutical properties such as antibacterial, antifungal, anticancer, antioxidants, antitubercular, antimalarial and anti-inflammatory. Due to lack of new antibiotics as well older antibiotic are rapidly proving ineffective, derivatives of triazine would be of great significance in future prospective.
This investigation is based on a very remarkable and interesting orchid of the genus Dendrobium w... more This investigation is based on a very remarkable and interesting orchid of the genus Dendrobium widely available in Meghalaya (India) and it is the world second largest orchid genus. The purpose of the study was to evaluate the anti-oxidant and anti-pyretic activity of leaf of Dendrobium chrysanthum. As the plants believed traditionally to have some anti-inflammatory activity used by the rural people of Meghalaya, use of medicinal plants and plants extract for the health procurement has always remain a common choice for the North- eastern people of India since ancient time. The leaf of Dendrobium c. was collected from Shillong, Meghalaya and extraction is done by using methanol as a solvent. The methanol extract found to have the constituents such as carbohydrate, glycoside, alkaloids, phenol and flavonoids. Acute anti-pyretic activity for the extract was investigated in pyrexia rat. Temperature level was determined after 1hours, 2 hours, 4 hours and 6 hours after giving the extrac...
Wound healing is a vital physiological process that helps to retain the integrity of the skin aft... more Wound healing is a vital physiological process that helps to retain the integrity of the skin after it has been damaged, whether by accident or by a deliberate operation. In Tinsukia district, Assam, tribal people and folklore traditions employ a wide variety of plants/plant extracts/decoctions or pastes to cure wounds. This study is designed to explore the ethnomedicinal plants used for the wound healing properties by the people of Tinsukia district, Assam. The Documentation of potential ethnobotanical information of traditionally used medicinal plant with wound healing activity will facilitates the scientific evaluation to look forward into a leading scientific prospect for the development of new herbal therapy for wound healing.
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