The current study aimed at exploring hepatoprotective potential of Parrotiopsis jacquemontiana leaves methanol extract (PJM) in rat. PJM constituted of significant amount of total phenolic and total flavonoid content. PJM and ethyl... more
The current study aimed at exploring hepatoprotective potential of Parrotiopsis jacquemontiana leaves methanol extract (PJM) in rat. PJM constituted of significant amount of total phenolic and total flavonoid content. PJM and ethyl acetate fraction (PJE) exhibited strong antioxidant potential (DPPH, hydroxyl ion, nitric oxide, iron chelating, β-carotene, reducing power and phosphomolybdate assay) in comparison to other extracts. CCl4 toxicity displayed significant (p<0.05) increase in level of TBARS, H2O2, nitrite while a decrease in SOD, CAT, POD and GSH in liver samples of CCl4 treated group. Serum analysis indicated significant increase in levels of ALT, AST and ALP and globulin whereas a decrease in albumin and total protein was also reported. In addition, levels of pro-inflammatory and fibrogenic cytokines (TNF-α, IL-6, TGF.β1, and leptin) of liver serum were elevated whereas adiponectin (anti-inflammatory cytokine) level was decreased in treated rats. CCl4 induced DNA damag...
BackgroundIntegrated care for diabetes and associated conditions at primary level health facilities can make care available to a much larger population, especially in rural areas.AimThis process evaluation was to understand how the... more
BackgroundIntegrated care for diabetes and associated conditions at primary level health facilities can make care available to a much larger population, especially in rural areas.AimThis process evaluation was to understand how the authors' integrated care was implemented and experienced by the care providers and patients, and to inform modifications prior to province-wide scale-up.Design & settingThe mixed-method study was conducted as part of a cluster randomised trial on integrated diabetes care at 14 public health facilities.MethodThe care practices were assessed by analysing the routine clinical records of 495 registered patients with diabetes. Then semi-structured interviews with service providers and patients were used to understand their respective care experiences. A framework approach was applied to analyse and interpret the qualitative data.ResultsThe intervention and the study were implemented as intended under routine conditions in rural health centres. Key service ...
BackgroundIn Pakistan about 18% of all adults are affected by hypertension, and only one in eight of the prevalent cases have their hypertension controlled. As in many other low-middle income countries, a public–private partnership... more
BackgroundIn Pakistan about 18% of all adults are affected by hypertension, and only one in eight of the prevalent cases have their hypertension controlled. As in many other low-middle income countries, a public–private partnership approach is being considered for delivering non-communicable disease care in urban areas.AimThis process evaluation was undertaken to understand how an integrated care intervention was experienced by the care providers and patients, and to inform modifications before possible scaling.Design & settingThe mixed-methods study was conducted as part of a cluster randomised trial on integrated hypertension care at 26 private clinics.MethodThe care practices were assessed by analysing the clinical records of 1138 registered patients with hypertension. Then semi-structured interviews with service providers and patients were used to understand their respective care experiences. A framework approach was applied to analyse and interpret the qualitative data.ResultsD...
Personal Care Assistant (PCA) has created a centralized corporate culture in which the board of director or the higher management hold the power of decision making, the lower management must abide by the decisions made by upper management.
