Celal Bayar University
Psychiatry
Background: Immunologic mechanisms may be responsible for the development and maintenance of schizophrenia symptoms. Aim: The aim of this study is to measure tumor necrosis factor-alpha (TNF-α), soluble tumor necrosis factor-alpha... more
Background: Immunologic mechanisms may be responsible for the development and
maintenance of schizophrenia symptoms.
Aim: The aim of this study is to measure tumor necrosis factor-alpha (TNF-α), soluble tumor
necrosis factor-alpha receptor I (sTNF-αRI), and soluble tumor necrosis factor-alpha receptor
II (sTNF-αRII) levels in patients with schizophrenia and healthy individuals, and to determine
their relationship with the symptoms of schizophrenia.
Methods: Serum TNF-α, sTNF-αRI and sTNF-αRII levels were measured. Positive and
Negative Syndrome Scale (PANSS) was administered in patients with schizophrenia (n = 35),
and the results were compared with healthy controls (n = 30). Hierarchical regression analyses
were undertaken to predict the levels of TNF-α, sTNF-αRI and sTNF-αRII.
Results: No significant difference was observed in TNF-α levels, but sTNF-αRI and sTNF-
αRII levels were lower in patients with schizophrenia. Serum sTNF-αRI and sTNF-αRII
levels were found to be negatively correlated with the negative subscale score of the PANSS,
and sTNF-αRI levels were also negatively correlated with the total score of the PANSS.
Smoking, gender, body mass index were not correlated with TNF-α and sTNF-α receptor
levels.
Conclusions: These results suggest that there may be a change in antiinflammatory response
in patients with schizophrenia due to sTNF-αRI and sTNF-αRII levels. The study also
supports low levels of TNF activity in schizophrenia patients with negative symptoms.
maintenance of schizophrenia symptoms.
Aim: The aim of this study is to measure tumor necrosis factor-alpha (TNF-α), soluble tumor
necrosis factor-alpha receptor I (sTNF-αRI), and soluble tumor necrosis factor-alpha receptor
II (sTNF-αRII) levels in patients with schizophrenia and healthy individuals, and to determine
their relationship with the symptoms of schizophrenia.
Methods: Serum TNF-α, sTNF-αRI and sTNF-αRII levels were measured. Positive and
Negative Syndrome Scale (PANSS) was administered in patients with schizophrenia (n = 35),
and the results were compared with healthy controls (n = 30). Hierarchical regression analyses
were undertaken to predict the levels of TNF-α, sTNF-αRI and sTNF-αRII.
Results: No significant difference was observed in TNF-α levels, but sTNF-αRI and sTNF-
αRII levels were lower in patients with schizophrenia. Serum sTNF-αRI and sTNF-αRII
levels were found to be negatively correlated with the negative subscale score of the PANSS,
and sTNF-αRI levels were also negatively correlated with the total score of the PANSS.
Smoking, gender, body mass index were not correlated with TNF-α and sTNF-α receptor
levels.
Conclusions: These results suggest that there may be a change in antiinflammatory response
in patients with schizophrenia due to sTNF-αRI and sTNF-αRII levels. The study also
supports low levels of TNF activity in schizophrenia patients with negative symptoms.
- by Sedat Batmaz and +2
- •
- Psychiatry, Immunology, Psychosis, Schizophrenia
An association or a casual link has been proposed between the neuroendocrinological and neuroimmunological changes attributed to either depression or cancer. This study investigated whether breast cancer patients with and without major... more
An association or a casual link has been proposed between the neuroendocrinological and neuroimmunological changes attributed to either depression or cancer. This study investigated whether breast cancer patients with and without major depression exhibit plasma interleukin-6 abnormalities and dexamethasone suppression test results. Four groups, each consisting of 30 women (1--healthy women, 2--patients with major depression, 3--breast cancer patients without major depression, 4--breast cancer patients with major depression), were compared to each other. Psychiatric evaluations were made by structured clinical interview for DSM-IV. Severity of depression was measured with the Hamilton Depression Rating Scale. Plasma levels of interleukin-6 were measured. A dexamethasone suppression test was applied. Breast cancer patients with major depression had markedly higher plasma levels of interleukin-6 than the other group. All breast cancer patients with depression had abnormal dexamethasone suppression test results. These findings suggest a hypothalamo-pituitary-adrenal axis activation and plasma levels of interleukin-6 and plasma interleukin-6 elevation and plasma levels if interleukin-6 and plasma levels of post cortisol concentrations. Evidence for a casual link or association of major depression with immune and endocrinological activation needs to be investigated further.
It is not scarce that patients experience various extrapyramidal symptoms (EPS) during antidepressant drug therapy. Thus, choice of an antidepressant drug in case of extrapyramidal side effects, at present, is a dilemma. Escitalopram,... more
It is not scarce that patients experience various extrapyramidal symptoms (EPS) during antidepressant drug therapy. Thus, choice of an antidepressant drug in case of extrapyramidal side effects, at present, is a dilemma. Escitalopram, which is a recently marketed selective serotonin reuptake inhibitors (SSRI), has no such reputation. There is just one case reported for tianeptine that induced abnormal involuntary movements/extrapyramidal side effects. We would like to present a case that was successfully managed with bupropion which had developed EPS during 2 different SSRI (sertraline and escitalopram) and tianeptine therapy.
- by haldun soygur and +2
- •
- Case Report, Humans, Male, Mental Disorders
Kabul tarihi / Date of acceptance: 15 Austos 2008 / August 15, 2008 ÖZET: Aripiprazol'ün farmakodinamik ve farmakokinetik özel- likleri Birinci kuflak antipsikotik ilaçlar›n klinik kullan›ma girmelerinden bu yana geçen elli y›l›... more
Kabul tarihi / Date of acceptance: 15 Austos 2008 / August 15, 2008 ÖZET: Aripiprazol'ün farmakodinamik ve farmakokinetik özel- likleri Birinci kuflak antipsikotik ilaçlar›n klinik kullan›ma girmelerinden bu yana geçen elli y›l› aflk›n süre içinde, farkl› etki mekanizmalar› üzerin- den etki gösteren yeni antipsikotik ilaçlar›n bulunabilmesi için büyük bir çaba harcanm›flt›r. Atipik antipsikotikler içinde, dopamin D2 resep- törleri üzerinde k›smi
To investigate quality of life and its association with depression in patients with major depressive disorder. The study included 74 patients diagnosed with major depressive disorder according to DSM-IV. The Hamilton Depression Rating... more
To investigate quality of life and its association with depression in patients with major depressive disorder. The study included 74 patients diagnosed with major depressive disorder according to DSM-IV. The Hamilton Depression Rating Scale (HAM-D) was used to assess the severity of depression; and the, Medical Outcomes Study Short Form-36 (MOS SF-36) and EuroQol 5-D (EQ-5D) were used to measure quality of life. In the assessment of quality of life, it was determined that Patients with major depressive disorder scored significantly lower on all domains of MOS SF-36 compared to Turkish normative data. The depressive disorder patients had lower EQ-5D health utility index scores, in comparison to Turkish normative data. There was a significant negative correlation between mean HAM-D score and all domains of MOS SF-36 and EQ-5D health utility index scores. When quality of life in depressive patients was compared according to episode type, patients with recurrent type major depressive di...
- by haldun soygur and +2
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- Education, Quality of life, Adolescent, Humans
This study aimed to compare the clinical and social benefits associated with Optimal Case Management (OCM) treatment that employ cognitive-behavioural strategies to those associated with Routine Case Management (RCM) that is widely used... more
This study aimed to compare the clinical and social benefits associated with Optimal Case Management (OCM) treatment that employ cognitive-behavioural strategies to those associated with Routine Case Management (RCM) that is widely used in community health services. Hundred patients with schizophrenia were randomly allocated to OCM and RCM treatment conditions. Patients in the OCM condition showed significantly more improvement on all measures compared to patients in RCM condition. Improvement on clinical symptoms and social functioning achieved by OCM tended to show a regular and continuous pattern throughout the course of the study. The results of this study suggest that every optimal treatment should aim improvement in social functioning and therefore quality of life of the patients.
Introduction: The aim of this study is to adapt the Multidimensional Observation Scale for Elderly Subjects developed by Helmes, Csapo and Short (1987) to Turkish for the aged care workers. The Multidimensional Observation Scale for... more
Introduction: The aim of this study is to adapt the Multidimensional Observation Scale for Elderly Subjects developed by Helmes, Csapo and Short (1987) to Turkish for the aged care workers. The Multidimensional Observation Scale for Elderly Subjects was developed in order to assess the psycho-social functioning of older adults. Methods: The scale has five functional domains, each consisting of eight items. There are a total of 40 items in the scale. The scale was applied to 229 older adults by two social workers who are studying in the field. There were 119 older adults who volunteered to participate in the study among 233 older adults staying in Karabük Yücel Nursing Home and Kastamonu Nursing and Rehabilitation Center and 110 older adults living with their families in Kastamonu. Results: The Cronbach Alpha values of the functional domains of the scale were found to be .89 for self-care; .85 for disorientation; .80 for depression/anxiety; .77 for irritability, and .87 for withdrawal, respectively. As a result of the confirmatory factor analysis, it was determined that the distribution of the items in the Multidimensional Observation Scale for Elderly Subjects to the subscales was similar to the distribution in the original scale. Furthermore, reliability values of the scale and its subscales are adequate. Conclusion: It is thought that the Turkish form of the scale can be used to evaluate multidimensional and determine the cognitive, psychological and social functionings of older adults who are in institutional care or live with their families in Turkey.
- by haldun soygur and +1
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- Functional Analysis, Elderly, Moses