Abstract: OBJECTIVE: This study aimed to further clarify the underlying pathomechanism of non-union skeletal fractures. METHODS: Gene expression profile dataset GSE494 obtained from six non-union skeletal fracture and six normal samples was downloaded from the Gene Expression Omnibus database. Overlapping genes in at least two platforms were analyzed, and differentially expressed genes (DEGs) between normal and disease groups were screened. Transcriptional regulatory relationships and differentially regulated modules of various transcription factors (TFs) were determined. Differentially regulated modules with unknown functions were subjected to functional enrichment analysis. RESULTS: Overall, 4,252 overlapping genes in at least two platforms and 77 DEGs, including 31…up and 46 downregulated genes, were obtained. Overall, 64,623 transcriptional regulatory relationships, including 49 TFs and 3,900 target genes, and 9 significant modules for differential regulation were identified. Three modules with unknown functions regulated by TFs, including zinc finger, ZZ-type containing 3 (ZZZ3), nuclear TF Y, alpha (NFYA), and POU class 2 homeobox 2 (POU2F2), were identified. Enriched GO-BP terms of NFYA and POU2F2 modules included cell adhesion and related terms and those of ZZ3 included cell cycle, cell proliferation, and associated terms. CONCLUSION: Three TFs, including ZZZ3, POU2F2, and NFYA, and their regulated modules may have important effects on non-union skeletal fractures. Cell proliferation may be related with ZZZ3; cell adhesion and its similar process may be related with POU2F2 and NFYA.
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Abstract: We discuss the interpolation strategies related to Richardson extrapolation and repeated Richardson extrapolation. We emphasize that, in most computations, the interest is in obtaining accurate solution on the current computational grid, not that on the coarse level grids on which the extrapolated solutions reside. We tackle the interpolation issue that has largely been overlooked in Richardson extrapolation related applications. We present numerical experiments to support our analysis.
Keywords: Computational grid, finite difference scheme, Richardson extrapolation, interpolation, high order solution
Abstract: Remote sensing is an indispensable technical way for monitoring earth resources and environmental changes. However, optical remote sensing images often contain a large number of cloud, especially in tropical rain forest areas, make it difficult to obtain completely cloud-free remote sensing images. Therefore, accurate cloud detection is of great research value for optical remote sensing applications. In this paper, we propose a saliency model-oriented convolution neural network for cloud detection in remote sensing images. Firstly, we adopt Kernel Principal Component Analysis (KCPA) to unsupervised pre-training the network. Secondly, small labeled samples are used to fine-tune the network structure. And, remote…sensing images are performed with super-pixel approach before cloud detection to eliminate the irrelevant backgrounds and non-clouds object. Thirdly, the image blocks are input into the trained convolutional neural network (CNN) for cloud detection. Meanwhile, the segmented image will be recovered. Fourth, we fuse the detected result with the saliency map of raw image to further improve the accuracy of detection result. Experiments show that the proposed method can accurately detect cloud. Compared to other state-of-the-art cloud detection method, the new method has better robustness.
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Abstract: This paper presents some continuous dependence theorems on solutions of uncertain differential equations based on uncertain measure. We first introduce some properties on solution of uncertain differential equation. And then, we provide a continuous dependence theorem, and a continuity theorem to the initial value. In the proposed continuity theorem, the solution is regarded as a ternary function of initial values. Furthermore, we discuss how the solution continuously depends on initial value and parameter, and propose two theorems, namely, continuous dependence theorem on parameter, and continuity theorem on parameter to the initial value.
Abstract: With the popularity of cloud computing, an increasing number of institutions outsource their data to a third-party cloud system which could be untrusted. The institutions encrypt their data before outsourcing to protect data privacy. On the other hand, data mining techniques are used widely but computationally intensive, especially for large datasets. Combining data from different institutions for a big and varied training set helps enhance data mining performance. Therefore, it is important to make the cloud system which has powerful computing abilities run data mining algorithms on the encrypted data from multiple institutions. Two challenges need attention – how to…compute on encrypted data under multiple keys and how to verify the correctness of the result. There are no existing methods that solve the two challenges at the same time. Elastic net is a useful linear regression tool to find genomic biomarkers. In this paper, we propose the first privacy-preserving verifiable elastic net protocol based on reduction to support vector machine using two non-colluding servers. We construct a homomorphic cryptosystem that supports one multiply operation and multiple add operations under both single key and different keys. We allow the involved institutions to verify the correctness of the final result. The collaboration between multiple institutions is made possible without jeopardizing the privacy of data records. We formally prove that our protocol is secure and implement the protocol. The experimental results show that our protocol runs reasonably fast, and thus can be applied in practice.
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Abstract: Cavitation has great application potential in microvessel damage and targeted drug delivery. Concerning cavitation, droplet vaporization has been widely investigated in vitro and in vivo with plasmonic nanoparticles. Droplets with a liquid dodecafluoropentane (DDFP) core enclosed in an albumin shell have a stable and simple structure with good characteristics of laser absorbing; thus, DDFP droplets could be an effective aim for laser-induced cavitation. The DDPF droplet was prepared and perfused in a mimic microvessel in the optical microscopic system with a passive acoustic detection module. Three patterns of laser-induced cavitation in the droplets were observed. The emitted acoustic signals showed…specific spectrum components at specific time points. It was suggested that a nanosecond laser pulse could induce cavitation in DDPF droplets, and specific acoustic signals would be emitted. Analyzing its characteristics could aid in monitoring the laser-induced cavitation process in droplets, which is meaningful to theranostic application.
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Abstract: In the mean-variance-skewness-kurtosis framework, this paper discusses an uncertain higher-order moment portfolio selection problem when security returns are given by experts’ evaluations. Based on uncertainty theory and the assumption that the security returns are zigzag uncertain variables, an uncertain multi-objective portfolio optimization model is proposed by considering the maximization of both the expected return and skewness of portfolio return while simultaneously minimizing the risk and kurtosis of portfolio return. Subsequently, the proposed model is transformed into a single-objective programming model by using fuzzy programming approach, in which investor preferences for high moments are incorporated. Furthermore, a modified flower pollination algorithm…(MFPA) is developed for solution, in which PSO in local update strategy (PSOLUS) and dynamic switching probability strategy (DSPS) are employed to enhance the local searching and global searching abilities. Finally, a numerical example is presented to illustrate the application of the proposed model and solution comparisons are also given to demonstrate the effectiveness of the designed algorithm.
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Abstract: Human action recognition in naturalistic videos is an important task with a broad range of applications. Recently, the encoder-decoder framework based on attention mechanism has been applied to action recognition. Although such conventional methods reach state-of-the-art, they always face a bottleneck of distinguishing similar actions. To solve this problem, we propose a novel recurrent attention convolutional neural network (RACNN), which incorporates convolutional neural networks (CNNs), long short-term memory (LSTM) and attention mechanism. Inspired by the composition of the action, the pre-action and the result of action might be important parts of an action, we introduce bi-direction LSTM with hierarchical structure.…Additionally, the separated spatial-temporal attention is employed into our method. Furthermore, we find that incorporating spatio-temporal features extracted from three-dimensional CNNs (3DCNNs) and RGB features can enhance the relationship mined in each frame. Our comprehensive experimental results on two benchmark datasets, i.e., HMDB51 and UCF101, verify the effectiveness of our proposed methods and show that our proposals can significantly outperform the current state-of-the-art methods.
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Abstract: In order to remove efficiently haled-particles emissions from coal combustions, a new way was used to put forward the process of agglomeration and the atomization was produced by the nozzle and then sprayed into the flue before precipitation devices of power station boiler in order to make inhaled-particles agglomerate into bigger particles, which can be easily removed but not change existing running conditions of boiler. According to this idea, a model is set up to study agglomeration rate and effect forces between fly ash inhaled-particles and atomized agglomerator particles. The developed agglomeration rate was expressed by relative particle number decreasing…speed per unit volume. The result showed that viscosity force and flow resistance force give main influences on agglomeration effect of inhaled-particles, while springiness force and gravity have little effect on agglomeration effect of theirs. Factors influencing the agglomeration rate and effect forces are studied, including agglomerator concentration, agglomerator flux and agglomerator density, atomized-particles diameters and inhaled-particles diameter and so on.
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Abstract: A series of simulation experiments of nitrogen transportation, absorption and transformation were conducted, and the different cropping patterns of winter wheat and wastewater irrigation plans were taken into consideration. Based on the experiments, an integrated model of crop growth, roots distribution, water and nitrogen absorption by roots, water and nitrogen movement and transformation in soilcrop system by two-dimension was developed. Parameters and boundary conditions were identified and an effective computing method for optimizing watering and wastewater irrigating plans was provided.
Keywords: nitrogen absorption and movement, integrated numerical model, soil-crop system