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Authors: Boyeson, Michael G.

Article Type: Research Article

Abstract: This article reviews the relationships between alterations in several neurotransmitter systems and functional recovery of sensory and motor functions after trauma to the central nervous system in animal models. The timing of administration of promising therapeutic agents is discussed in relationship to the role of rehabilitation while the subject is under the influence of these agents. If caution is not employed in administering some drugs after injury, deleterious effects on recovery can be observed. Finally, attention is given to the mechanisms of drug-induced recovery and speculation concerning possible links to protein kinases and accessing of learned behaviors that are transiently …depressed after brain injury. Show more

DOI: 10.3233/NRE-1991-1107

Citation: NeuroRehabilitation, vol. 1, no. 1, pp. 33-43, 1991

Authors: Boyeson, Michael G. | Feeney, Dennis M.

Article Type: Research Article

Abstract: The following experiment was designed to examine the effects of unilateral cerebellar cortex lesions and pharmacological postinjury treatments with catecholamine drugs on recovery of beam walking ability in rats. Rats trained on a beam walking task were initially given either amphetamine, haloperidol, or a combination of the drugs at 24 h after injury, and tested at various intervals after drug administration. Six total doses were given to animals at 5d intervals during recovery. All drugs retarded recovery of function on the beam walking task compared to saline controls. Animals with cortical lesions that involved the deep cerebellar nuclei showed no …recovery on the beam, regardless of group assignment. Phenoxybenzamine and propranalol were both ineffective in reinstating the beam walking deficit in those animals that demonstrated recovery on the beam walking task. The results indicate that the cerebellum plays a particularly important role in recovery of beam walking ability, and may contribute to beam walking recovery commonly observed after sensorimotor cortex ablations. Show more

Keywords: Catecholamine, Cerebellum, Diaschisis, Brain injury, Amphetamine

DOI: 10.3233/RNN-1991-3501

Citation: Restorative Neurology and Neuroscience, vol. 3, no. 5, pp. 227-233, 1991

Authors: Boyeson, Michael G. | Krobert, Kurt A. | Scherer, Paul J. | Grade, Charles M.

Article Type: Research Article

Abstract: Previous research has indicated that antagonists of locus ceruleus functioning, when administered during the acute phase of an injury, slow recovery of motor function following unilateral sensorimotor cortex injury. Following a recovery plateau in animals, it is possible to pharmacologically reinstate unilateral motor deficits in recovered animals with similar acting drugs given intraperitoneally. The present study was designed to localize the brain systems responsible for the reinstatement of the deficit after recovery from the cortical injury. The results indicate that maintaining functional recovery after injury is modulated by NE in the cerebellum contralateral to the injury, since microinfusions of phenoxybenzamine …into this structure reinstate motor deficits. Additionally, removal of the noradrenergic projection to contralateral cerebellum through unilateral lesions of the locus ceruleus reinstate unilateral deficits more severely than the drug administration. Show more

Keywords: Cerebellum, Norepinephrine, Alpha adrenergic, Locus ceruleus, Sensorimotor cortex, Brain injury, Recovery of function

DOI: 10.3233/RNN-1993-5404

Citation: Restorative Neurology and Neuroscience, vol. 5, no. 4, pp. 283-290, 1993