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Authors: Hossain, Shahanara | Alim, Abdul | Takeda, Kazuya | Kaji, Hiroyuki | Shinoda, Tomotaka | Uéda, Kenji

Article Type: Research Article

Abstract: The NAC region of NACP/α-synuclein is a secondary component of Alzheimer's disease amyloid. α-Synuclein is a major component of Lewy bodies, a typical neuropathological feature of Parkinson's disease. However, the physiological role and deposition mechanisms of α-synuclein are unknown. Structural analyses of α-synuclein should provide a better understanding of its biochemical characteristics. We investigated the digestion of α-synuclein withα-chymotrypsin and cathepsin D, which are reported to be involved in amyloidogenesis, under various conditions in vitro. There are many putative cleavage sites for these enzymes in α-synuclein, including in the NAC region. However, most of the predicted sites remained undigested, and …the NAC region was found to be intact even after extensive digestion. This peculiar characteristic of α-synuclein may be relevant to the abnormal deposition of this molecule in α-synuclein-associated neurodegenerative diseases. Show more

DOI: 10.3233/JAD-2001-3608

Citation: Journal of Alzheimer's Disease, vol. 3, no. 6, pp. 577-584, 2001