Your search for: 'author:("Zhou, Yong")' has returned 6 results. (0.013s) Save search

Authors: Yang, Xingjiang | Zhou, Yong | Zhu, Qingxing | Wu, Zhendong

Article Type: Research Article

Abstract: Extreme learning machine (ELM) has been proved to be an efficient and effective machine learning method for pattern classification and regression. However, ELM is mainly applied to traditional supervised learning problems. ELM is not commonly used in multi-label image classification. In this paper, we propose a joint graph regularized extreme learning machine (JGELM) by simultaneously considering the feature information and label correlation of data. Specifically, we exploit the feature distance and label correlation in the local neighborhood. To this end, a joint graph regularizer based on a newly designed graph Laplacian to characterize both properties is formulated and incorporated into …the ELM objective. Four popular multi-label image data sets are employed to test the proposed method. The experimental results show that JGELM are competitive with state-of-the-art multi-label classification algorithms in terms of accuracy and efficiency. Show more

Keywords: Extreme learning machine, feature distance, label correlation, multi-label image classification

DOI: 10.3233/JCM-180783

Citation: Journal of Computational Methods in Sciences and Engineering, vol. 18, no. 1, pp. 213-219, 2018

Authors: Zhou, Yong | Mu, HaiYing | Jiang, Jianjun | Zhang, Li

Article Type: Research Article

Abstract: Currently, there is a trend in nuclear power plants (NPPs) toward introducing digital and computer technologies into main control rooms (MCRs). Safe generation of electric power in NPPs requires reliable performance of cognitive tasks such as fault detection, diagnosis, and response planning. The digitalization of MCRs has dramatically changed the whole operating environment, and the ways operators interact with the plant systems. If the design and implementation of the digital technology is incompatible with operators’ cognitive characteristics, it may have negative effects on operators’ cognitive reliability. Firstly, on the basis of three essential prerequisites for successful cognitive tasks, a causal …model is constructed to reveal the typical human performance issues arising from digitalization. The cognitive mechanisms which they impact cognitive reliability are analyzed in detail. Then, Bayesian inference is used to quantify and prioritize the influences of these factors. It suggests that interface management and unbalanced workload distribution have more significant impacts on operators’ cognitive reliability. Show more

Keywords: digital main control room, cognitive reliability, human factors issues, human errors, bayesian network

DOI: 10.3233/WOR-2012-0231-714

Citation: Work, vol. 41, no. Supplement 1, pp. 714-721, 2012

Authors: Peng, Lang | Xiang, Qingwei | Zhou, Yong | Yin, Renyi

Article Type: Research Article

Abstract: Background: The joint associations of handgrip strength (HGS) weakness and asymmetry with cognitive decline remain understudied in older adults. Objective: To investigate the associations between HGS weakness, asymmetry, and lower cognitive function in a nationally representative sample of older Americans. Methods: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey 2011–2014. Weakness was defined as HGS <26 kg for men and <16 kg for women. Asymmetry was determined by calculating the ratio of dominant to non-dominant HGS. Participants with an HGS ratio <0.90 or >1.10 were classified as having any HGS asymmetry. Those with an HGS ratio >1.10 …exhibited dominant HGS asymmetry, while those with an HGS ratio <0.90 displayed nondominant HGS asymmetry, respectively. Lower cognitive functioning was defined as global cognitive composite scores more than 1 standard deviation below the mean. Covariate-adjusted logistic regression models were used to analyze the associations between HGS asymmetry/weakness and lower cognitive functioning. Results: Compared to individuals with non-weak and symmetric HGS, those with any HGS asymmetry alone and weakness alone had 1.017 (95% confidence interval [CI]: 0.707–1.463) and 1.391 (95% CI: 0.542–3.571) greater odds for cognitive decline, while co-occurrence of both HGS asymmetry and weakness was associated with 3.724 (95% CI: 1.711–8.107) greater odds for lower cognitive function after controlling for confounders. Cnclusions: Individuals exhibiting both diminished and asymmetrical HGS demonstrated an elevated susceptibility to cognitive impairment, thereby implying that the inclusion of HGS asymmetry assessment in conjunction with weakness evaluation may enhance the accuracy of prognosticating cognitive decline. Show more

Keywords: Alzheimer’s disease, cognitive dysfunction, cross-sectional study, geriatrics, handgrip strength

DOI: 10.3233/JAD-231375

Citation: Journal of Alzheimer's Disease, vol. 99, no. 1, pp. 393-402, 2024

Authors: Zhou, Yong-Mei | Yao, Yi-Lin | Liu, Wei | Shen, Xue-Min | Shi, Lin-Jun | Wu, Lan

Article Type: Research Article

Abstract: BACKGROUND: Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the mouth. Some studies have found that multiple microRNAs (miRs) participate in OSCC physiological and pathological processes. METHODS: We explored the mechanism of action of miR-134 in OSCC involving the PI3K-Akt signaling pathway. Different bioinformatics methods were used to analyze the potential genes and their related miRs in OSCC. Tumor stem cells were separated from OSCCs through magnetic cell sorting. Regulatory pattern between miR-134 and LAMC2 in OSCC was evaluated by ectopic expression, knockdown and reporter assay experiments. The expression of miR-134, LAMC2, genes in PI3K-Akt signaling …pathway, and apoptosis-related genes was detected. Cell proliferation was assessed by MTT assay, cell invasion by scratch test, cell migration by Transwell assay, cell cycle and apoptosis by flow cytometry, and cell growth and migration by xenograft tumor in nude mice. LAMC2 was predicted as the crucial factor related to OSCC using different chip data, and miR-134 was predicted to specifically bind LAMC2 in all five databases. RESULTS: Overexpressed miR-134 or silenced LAMC2 was observed to inhibit cell proliferation, migration, invasion of OSCC cells, growth of subcutaneous xenograft in nude mice, as well as promote OSCC cell apoptosis. LAMC2, a target gene of miR-134, decreased following miR-134 promotion, while the PI3K-Akt signaling pathway was inactivated following LAMC2 knockdown. Furthermore, we also observed that the effect of overexpressed miR-134 was enhanced when LAMC2 was knocked down. CONCLUSIONS: Taken together, these findings suggest that miR-134-mediated direct downregulation of LAMC2 inhibits migration and invasion of tumor stem cells in OSCC by suppressing the PI3K-Akt signaling pathway. Show more

Keywords: MicroRNA-134, LAMC2, PI3K-Akt signaling pathway, oral squamous cell carcinoma, cell migration, cell invasion

DOI: 10.3233/CBM-191362

Citation: Cancer Biomarkers, vol. 29, no. 1, pp. 51-67, 2020

Authors: Liu, Peng | Zou, Dan | Yi, Long | Chen, Mingliang | Gao, Yanxiang | Zhou, Rui | Zhang, Qianyong | Zhou, Yong | Zhu, Jundong | Chen, Ka | Mi, Mantian

Article Type: Research Article

Abstract: Purpose: Acute hypobaric hypoxia (HH) causes persistent cognitive impairment, affecting memory function specifically. Mitochondrial dysfunction and synaptic morphological change were the prominent pathological features of HH exposure on brain. Quercetin, a flavonoid found in fruits, vegetables, leaves and grains, is reported to prevent ischemia induced by neuronal injury. This study investigated the efficacy of quercetin to ameliorate HH-induced memory deficit. Methods: Rats were exposed to HH equivalent to 5000 m for 7 days in a decompression chamber and received quercetin daily (50, 75 or 100 mg/kg·bw) via gavage during the period of exposure. Cognitive performance was assessed by the Morris …water maze test. In vitro, the effect of quercetin was tested in hippocampus tissue. Results: Quercetin, especially at 100 mg/kg·bw, significantly reduced HH-induced memory decline. Meanwhile, HH-induced hippocampus mitochondrial and synaptic lesions were ameliorated by quercetin. Furthermore, quercetin regulated the expression of sirtuin 1(Sirt1), PGC-1α, and the proteins related with mitochondrial biogenesis and dynamics. Moreover, quercetin increased expression of fibronectin type III domain-containing protein 5 (FNDC5) and brain-derived neurotrophic factor (BDNF), showing the PGC-1α/FNDC5/BNDF pathways might be involved in neuronal adaptation. Conclusions: The results suggest quercetin has prophylactic potential for amelioration of HH-induced memory impairment, which is associated with the mitochondrial and neuronal adaptation in hippocampus. Show more

Keywords: Hypobaric hypoxia, memory impairment, mitochondria, neuroprotection, PGC-1α, quercetin

DOI: 10.3233/RNN-140446

Citation: Restorative Neurology and Neuroscience, vol. 33, no. 2, pp. 143-157, 2015

Authors: Zhang, Jing | Goodlett, Dave R. | Quinn, Joseph F. | Peskind, Elaine | Kaye, Jeffrey A. | Zhou, Yong | Pan, Catherine | Yi, Eugene | Eng, Jimmy | Wang, Qin | Aebersold, Ruedi H. | Montine, Thomas J.

Article Type: Research Article

Abstract: Biomarkers to assist in the diagnosis and medical management of Alzheimer disease (AD) are a pressing need. We have employed a proteomic approach, microcapillary liquid chromatography mass spectrometry of proteins labeled with isotope-coded affinity tags (ICAT), to quantify relative changes in the proteome of human cerebrospinal fluid (CSF) obtained from the lumbar cistern. Using CSF from well-characterized AD patients and age-matched controls at 2 different institutions, we quantified protein concentration ratios of 42% of the 390 CSF proteins that we have identified and found differences ≥ 20% in over half of them. We confirmed our findings by western blot and …validated this approach by quantifying relative levels of amyloid precursor protein and cathepsin B in 17 AD patients and 16 control individuals. Quantitative proteomics of CSF from AD patients compared to age-matched controls, as well as from other neurodegenerative diseases, will allow us to generate a roster of proteins that may serve as specific biomarker panels for AD and other geriatric dementias. Show more

Keywords: Alzheimer disease, biomarkers, cerebrospinal fluid, proteomics

DOI: 10.3233/JAD-2005-7205

Citation: Journal of Alzheimer's Disease, vol. 7, no. 2, pp. 125-133, 2005