Your search for: 'author:("Zhuang, Lin")' has returned 2 results. (0.006s) Save search

Authors: Qu, Yi | Zhuang, Lin | Zhang, Huiying | Liu, Chang | Wang, Xiaonan

Article Type: Systematic Review

Abstract: Background: Depression is one of the most common symptoms in patients with dementia. Objective: This meta-analysis aimed to evaluate the effect of light therapy on depression associated with dementia by using a single scale. Methods: Published studies based on the terms including “Dementia”, “depression”, and “Phototherapy” were searched. Web of Science, PubMed, Embase, CiNii, CNKI, Wanfang Database, and China Biology Medicine disc were adopted to collect randomized controlled studies or cross-controlled studies using the Cornell Scale for Depression in Dementia (CSDD) until February 2022. GRADE and Review Manager Version 5.4.1 were employed to assess the risk of bias. A meta-analysis …was conducted by R 4.0.2 software based on the changes in CSDD scores. Results: A total of 1,055 studies were retrieved from the databases, and six studies were included after screening. Some 406 people with dementia were included with an average age of over 80 years. Forest plot results showed that light intervention improved depression scores of dementia patients (MD = –2.59, 95% CI: –4.46 to –0.71), and light intensity less than 1,000 lux improved depression symptoms of dementia patients (MD = –2.76, 95% CI: –4.55 to –0.97). An intervention that lasted 8 to 12 weeks was the most effective (MD = –3.77, 95% CI: –6.93 to –0.60), and non-stable interventions such as ceiling LED lights exerted more positive effects (MD = –2.12, 95% CI: –3.38 to –0.85). Conclusion: The overall results of the meta-analysis suggested that light intervention can improve the depressive symptoms of older patients with dementia. Show more

Keywords: Alzheimer’s disease, cornell scale for depression in dementia, dementia, depression, light therapy, older patients

DOI: 10.3233/JAD-221204

Citation: Journal of Alzheimer's Disease, vol. 93, no. 4, pp. 1223-1235, 2023

Authors: Zhuang, Lin | Wen, Wei | Trollor, Julian N. | Kochan, Nicole A. | Reppermund, Simone | Brodaty, Henry | Sachdev, Perminder

Article Type: Research Article

Abstract: The fornix is a major efferent tract of the hippocampus, a structure critical for normal memory function. However, the role of structural degradation of the fornix in memory dysfunction in mild cognitive impairment (MCI) has remained unclear. We used diffusion tensor tractography to measure microstructural properties of the fornix and the corticospinal tract (CST), as a control tract, in 206 cognitively normal subjects, 76 amnestic MCI (aMCI) and 51 non-amnestic MCI (naMCI) subjects. Hippocampal volumes were measured using deformation-based morphometry. We found significant fractional anisotropy reductions in the left fornix and radial diffusivity (RD) increases in bilateral fornices in aMCI, …but not in naMCI, compared with controls. No significant changes in the CST were found in aMCI subjects, but naMCI subjects showed significantly increased RD and axial diffusivity of the right CST, compared with controls. Increased left fornical RD measure was correlated with poor verbal memory performance in aMCI subjects. In addition, reduced microstructural integrity of the fornix was associated with hippocampal atrophy in aMCI. This study suggests that microstructural alteration of the fornix is a contributor to early episodic memory dysfunction in non-demented individuals. Show more

Keywords: Amnestic mild cognitive impairment, diffusion tensor tractography, fornix, hippocampus, non-amnestic mild cognitive impairment

DOI: 10.3233/JAD-2012-111766

Citation: Journal of Alzheimer's Disease, vol. 29, no. 3, pp. 629-639, 2012