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The interplay of sequence conservation and T cell immune recognition

Authors:

Anne Bresciani,

Jason Greenbaum,

Cecilia S. Lindestam Arlehamn,

Alessandro Sette,

Morten Nielsen,

Bjoern PetersAuthors Info & Claims

BCB '14: Proceedings of the 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics

Pages 739 - 743

https://doi.org/10.1145/2649387.2660843

Published: 20 September 2014 Publication History

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Abstract

Predicting which peptides can elicit a T cell response (i.e. are immunogenic) is of great importance for many immunological studies. While it is clear that MHC binding is a necessary requirement for peptide immunogenicity, other variables exist that are incompletely understood.

In this study we examined the hypothesis that conservation of a peptide in bacteria that are part of the healthy human microbiome leads to a reduced level of immunogenicity due to tolerization of T cells to the commensal bacteria. This was done by comparing experimentally characterized T cell epitope recognition data from the Immune Epitope Database with their conservation in the human microbiome. Indeed, we did see a lower immunogenicity for conserved peptides conserved. While many aspects how this conservation comparison is done require further optimization, this is a first step towards a better understanding T cell recognition of peptides in bacterial pathogens is influenced by their conservation in commensal bacteria. If the further work proves that this approach is successful, the degree of overlap of a peptide with the human proteome or microbiome could be added to the arsenal of tools available to assess peptide immunogenicity.

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Cited By

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Ros-Lucas ABigey PChippaux JGascón JAlonso-Padilla J(2022)Computer-Aided Analysis of West Sub-Saharan Africa Snakes Venom towards the Design of Epitope-Based Poly-Specific AntivenomsToxins10.3390/toxins1406041814:6(418)Online publication date: 18-Jun-2022
https://doi.org/10.3390/toxins14060418
Ros-Lucas ACorrea-Fiz FBosch-Camós LRodriguez FAlonso-Padilla J(2020)Computational Analysis of African Swine Fever Virus Protein Space for the Design of an Epitope-Based Vaccine EnsemblePathogens10.3390/pathogens91210789:12(1078)Online publication date: 21-Dec-2020
https://doi.org/10.3390/pathogens9121078

Index Terms

The interplay of sequence conservation and T cell immune recognition
1. Applied computing
  1. Life and medical sciences

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Published In

BCB '14: Proceedings of the 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics

September 2014

851 pages

ISBN:9781450328944

DOI:10.1145/2649387

General Chairs:
Pierre Baldi
University of California, Irvine
,
Wei Wang
University of California, Los Angeles

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Association for Computing Machinery

New York, NY, United States

Publication History

Published: 20 September 2014

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BCB '14: ACM-BCB '14

September 20 - 23, 2014

California, Newport Beach

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Cited By

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Ros-Lucas ABigey PChippaux JGascón JAlonso-Padilla J(2022)Computer-Aided Analysis of West Sub-Saharan Africa Snakes Venom towards the Design of Epitope-Based Poly-Specific AntivenomsToxins10.3390/toxins1406041814:6(418)Online publication date: 18-Jun-2022
https://doi.org/10.3390/toxins14060418
Ros-Lucas ACorrea-Fiz FBosch-Camós LRodriguez FAlonso-Padilla J(2020)Computational Analysis of African Swine Fever Virus Protein Space for the Design of an Epitope-Based Vaccine EnsemblePathogens10.3390/pathogens91210789:12(1078)Online publication date: 21-Dec-2020
https://doi.org/10.3390/pathogens9121078

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