Abstract
Colour vision is based on the presence of multiple classes of cone each of which contains a different type of photopigment1. Colour matching tests have long revealed that the normal human has three cone types. Results from these tests have also been used to provide estimates of cone spectral sensitivities2. There are significant variations in colour matches made by individuals whose colour vision is classified as normal3â6. Some of this is due to individual differences in preretinal absorption and photopigment density, but some is also believed to arise because there is variation in the spectral positioning of the cone pigments among those who have normal colour vision. We have used a sensitive colour matching test to examine the magnitude and nature of this individual variation and here report evidence for the existence of two different long-wavelength cone mechanisms in normal humans. The different patterns of colour matches made by male and female subjects indicate these two mechanisms are inherited as an X-chromosome linked trait.
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References
Dartnall, H. J. A., Bowmaker, J. K. & Mollon, J. D. Proc. R. Soc. B220, 115â130 (1983).
Boynton, R. M. Human Color Vision (Holt, Rinehart and Winston, New York, 1979).
Alpern, M. J. Physiol., Lond. 288, 85â105 (1979).
Smith, V. C., Pokorny, J. & Starr, S. J. Vision Res. 16, 1087â1094 (1976).
Eisner, A. E. & MacLeod, D. I. A. J. Opt. Soc. Am. 71, 705â718 (1981).
MacLeod, D. I. A. & Webster, M. A. in Color Vision Physiology and Psychophysics (eds Mollon, J. D. & Sharpe, L. T.) 81â92 (Academic, London, 1983).
Linksz, A. An Essay on Color Vision and Clinical Color Vision Testing (Grune & Stratton, New York, 1964).
Nagy, A. L. J. opt. Soc. Am. 72, 571â577 (1982).
Wyszecki, G. & Stiles, W. S. Color Science: Concepts and Methods, Quantitative Data and Formulas (Wiley, New York, 1967).
Norren, D. V. & Vos, J. J. Vision Res. 14, 1237â1244 (1974).
Rushton, W. A. H. J. Physiol., Lond. 168, 345â359 (1963).
Crawford, B. H. in Handbook of Sensory Physiology, Vol. VII/4, Visual Psychophysics, (eds Jameson, D. & Hurvich, L. M.) 470â483 (Springer, Berlin, 1972).
Nagy, A. L., Purl, K. F. & Houston, J. S. Vision Res. 25, 661â669 (1985).
Kalmus, H. Diagnosis and Genetics of Defective Colour Vision (Pergamon, Oxford, 1965).
Dawis, S. M. Vision Res. 21, 1427â1430 (1981).
Nunn, B. J., Schnapf, J. L. & Baylor, D. A. Nature 309, 264â266 (1984).
Polyak, S. L. The Retina (Univ Chicago Press, Chicago, 1941).
Mellerio, J. Vision Res. 11, 129â141 (1971).
Said, F. S. & Weale, R. A. Gerontologia 3, 213â231 (1959).
Lyon, M. F. Am. J. hum. Genet. 14, 135â148 (1962).
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Neitz, J., Jacobs, G. Polymorphism of the long-wavelength cone in normal human colour vision. Nature 323, 623â625 (1986). https://doi.org/10.1038/323623a0
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DOI: https://doi.org/10.1038/323623a0
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