The cellular organelles we know as mitochondria are thought to have originated as symbiotic bacteria. Indeed, the two use common mechanisms to trigger innate immune responses to injury and infection, respectively.
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References
Mathers, C. D. & Loncar, D. PLoS Med. 3, e442 (2006).
Zhang, Q. et al. Nature 464, 104â107 (2010).
Moore, F. A. et al. J. Trauma 40, 501â512 (1996).
Iwasaki, A. & Medzhitov, R. Science 327, 291â295 (2010).
Mollen, K. P. et al. Shock 26, 430â437 (2006).
Cohen, M. J. et al. Crit. Care 13, R174 (2009).
Gray, M. W., Burger, G. & Lang, B. F. Genome Biol. 2, reviews1018.1â1018.5 (2001).
Ware, L. B. & Matthay, M. A. N. Engl. J. Med. 342, 1334â1349 (2000).
Looney, M. R. et al. J. Clin. Invest. 119, 3450â3461 (2009).
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Calfee, C., Matthay, M. Culprits with evolutionary ties. Nature 464, 41â42 (2010). https://doi.org/10.1038/464041a
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DOI: https://doi.org/10.1038/464041a
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