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View all- Toniolo IMascolini MCarniel EFontanella C(2022)Artificial sphincters: An overview from existing devices to novel technologiesArtificial Organs10.1111/aor.1443447:4(617-639)Online publication date: 14-Nov-2022
In Vivo Performance and Biocompatibility of an Intelligent Artificial Anal Sphincter System
Authors: 
Ding Han, Guo-Zheng Yan, Kai ZhaoAuthors Info & Claims
Ding Han, Guo-Zheng Yan, Kai ZhaoAuthors Info & ClaimsPages 111 - 118
Abstract
Severe fecal incontinence is an embarrassing and psychosocially debilitating condition that has a considerable negative impact on quality of the life. This article describes an intelligent artificial anal sphincter system (AASS) based on enteric cavity pressure signal feedback mechanism and its in vivo experiment in two dogs. The optimized AASS consists of an external telemetry unit, internal artificial anal sphincter (IAAS) and transcutaneous energy transfer charging system (TETCS). The new sphincter prosthesis was designed with pressure sensor to simulate the part function of the external anal sphincter. The devices were implanted in two dogs and studied for periods of up to 5 weeks. The efficacy of the device in achieving continence and sensing the stool was assessed. The biocompatibility and biosecurity, including blood supply of the rectum, blood serum chemistry, and histologic examination of tissue, were evaluated during and after experiment. Results of the chronic animal experiment demonstrated no significant tissue inflammation. Functionality and biocompatibility of the improved device have been proved.
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- In Vivo Performance and Biocompatibility of an Intelligent Artificial Anal Sphincter System
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December 2019
169 pages
ISBN:9781450372183
DOI:10.1145/3383783
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- Sun Yat-Sen University
- Seoul National University
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Published: 17 April 2020
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ICBRA '19
ICBRA '19: 2019 6th International Conference on Bioinformatics Research and Applications
December 19 - 21, 2019
Seoul, Republic of Korea
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View all- Toniolo IMascolini MCarniel EFontanella C(2022)Artificial sphincters: An overview from existing devices to novel technologiesArtificial Organs10.1111/aor.1443447:4(617-639)Online publication date: 14-Nov-2022
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