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ResearchIn-Press PreviewImmunologyPulmonology Open Access | 10.1172/JCI177242
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by Chowdhury, N. in: JCI | PubMed | Google Scholar |
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by Cephus, J. in: JCI | PubMed | Google Scholar
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
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1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by Wolf, M. in: JCI | PubMed | Google Scholar
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by Madden, M. in: JCI | PubMed | Google Scholar
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by Kuehnle, S. in: JCI | PubMed | Google Scholar
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by McKernan, K. in: JCI | PubMed | Google Scholar
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by Jennings, E. in: JCI | PubMed | Google Scholar
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by Arner, E. in: JCI | PubMed | Google Scholar |
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by Heintzman, D. in: JCI | PubMed | Google Scholar
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
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1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by Sugiura, A. in: JCI | PubMed | Google Scholar
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by Stier, M. in: JCI | PubMed | Google Scholar
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by Voss, K. in: JCI | PubMed | Google Scholar
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by Ye, X. in: JCI | PubMed | Google Scholar |
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by Scales, K. in: JCI | PubMed | Google Scholar
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by Krystofiak, E. in: JCI | PubMed | Google Scholar
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
Find articles by Gandhi, V. in: JCI | PubMed | Google Scholar |
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
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1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
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1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
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1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
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1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
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1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States of America
2Department of Medicine, Vanderbilt University Medical Center, Nashville, United States of America
3Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
4Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, United States of America
5Department of Cellular and Molecular Biology, Vanderbilt University Medical Center, Nashville, United States of America
6Department of Medicine, University of Wisconsin, Madison, United States of America
7Department of Medicine, University of Virginia, Charlottesville, United States of America
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Published October 15, 2024 - More info
Females have an increased prevalence of many Th17 cell-mediated diseases, including asthma. Androgen signaling decreases Th17 cell-mediated airway inflammation, and Th17 cells rely on glutaminolysis. However, it remains unclear whether androgen receptor (AR) signaling modifies glutamine metabolism to suppress Th17 cell-mediated airway inflammation. We show that Th17 cells from male humans and mice had decreased glutaminolysis compared to females, and that AR signaling attenuated Th17 cell mitochondrial respiration and glutaminolysis in mice. Using allergen-induced airway inflammation mouse models, we determined females had a selective reliance upon glutaminolysis for Th17-mediated airway inflammation, and AR signaling attenuated glutamine uptake in CD4+ T cells by reducing expression of glutamine transporters. Minimal reliance on glutamine uptake in male Th17 cells compared to female Th17 cells was also found in circulating T cells from patients with asthma. AR signaling thus attenuates glutaminolysis, demonstrating sex-specific metabolic regulation of Th17 cells with implications for Th17 or glutaminolysis targeted therapeutics.