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The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice
Figure 6
Metabolic parameters in Fto complete knockout mice.
(A) Average hourly oxygen consumption of 16∼17-week-old male Fto+/Δ and FtoΔ/Δ mice during the light and dark period. P = 0.1044 (light), and P = 0.0098(dark). (B) Average hourly oxygen consumption divided by lean mass. P<0.0001. (C) Average hourly carbon dioxide production of 16∼17-week-old male Fto+/Δ and FtoΔ/Δ mice during the light and dark period. P = 0.0463 (light), and P = 0.011(dark). (D) Average hourly carbon dioxide production divided by lean mass. P<0.0001. (E) Accumulative food intake over a period of 72 hours of 16∼17-week-old male Fto+/Δ and FtoΔ/Δ mice. P = 0.3015. (F) Food intake divided by lean mass. P = 0.0001. The number of mice used was 7 for each genotype. Statistical analyses were performed by unpaired t-test. **P<0.01. All values are mean ± s.e.m.