GABRR1

GABRR1
Identifiers
Aliases	GABRR1, gamma-aminobutyric acid type A receptor rho1 subunit, gamma-aminobutyric acid type A receptor subunit rho1
External IDs	OMIM: 137161; MGI: 95625; HomoloGene: 20470; GeneCards: GABRR1; OMA:GABRR1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q15 Start 89,177,504 bp End 89,231,278 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 A5|4 14.68 cM Start 33,132,521 bp End 33,163,588 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad Descending thoracic aorta ascending aorta pancreatic ductal cell tibialis anterior muscle deltoid muscle tibial arteries left coronary artery right coronary artery Top expressed in neural layer of retina embryo embryo muscle of thigh epithelium of lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chloride channel activity extracellular ligand-gated ion channel activity GABA-A receptor activity ion channel activity transmembrane signaling receptor activity ligand-gated ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane GABA-A receptor complex postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane chloride channel complex cell junction neuron projection glutamatergic synapse GABA-ergic synapse Biological process gamma-aminobutyric acid signaling pathway chloride transmembrane transport ion transport chloride transport chemical synaptic transmission ion transmembrane transport signal transduction regulation of membrane potential nervous system process regulation of postsynaptic membrane potential regulation of presynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2569 14408 Ensembl ENSG00000146276 ENSMUSG00000028280 UniProt P24046 P56475 RefSeq (mRNA) NM_001256703 NM_001256704 NM_001267582 NM_002042 NM_008075 RefSeq (protein) NP_001243632 NP_001243633 NP_001254511 NP_002033 NP_032101 Location (UCSC) Chr 6: 89.18 – 89.23 Mb Chr 4: 33.13 – 33.16 Mb PubMed search
Wikidata
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Gamma-aminobutyric acid receptor subunit rho-1 is a protein that in humans is encoded by the GABRR1 gene.

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family.

See also

• GABA_A-ρ receptor

Further reading

• Wang TL, Hackam A, Guggino WB, Cutting GR (1995). "A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors". J. Neurosci. 15 (11): 7684–7691. doi:10.1523/jneurosci.15-11-07684.1995. PMC 6578093. PMID 7472519.
• Hackam AS, Wang TL, Guggino WB, Cutting GR (1997). "The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction". J. Biol. Chem. 272 (21): 13750–13757. doi:10.1074/jbc.272.21.13750. PMID 9153229.
• Kusama T, Hatama K, Sakurai M, et al. (1999). "Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation". Neurosci. Lett. 255 (1): 17–20. doi:10.1016/S0304-3940(98)00696-X. PMID 9839716. S2CID 12933301.
• Hanley JG, Koulen P, Bedford F, et al. (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses". Nature. 397 (6714): 66–69. Bibcode:1999Natur.397...66H. doi:10.1038/16258. PMID 9892354. S2CID 4421437.
• Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3". Biochim. Biophys. Acta. 1447 (2–3): 307–312. doi:10.1016/S0167-4781(99)00167-0. PMID 10542332.
• Hanley JG, Jones EM, Moss SJ (2000). "GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1". J. Biol. Chem. 275 (2): 840–846. doi:10.1074/jbc.275.2.840. PMID 10625616.
• Filippova N, Sedelnikova A, Zong Y, et al. (2000). "Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C". Mol. Pharmacol. 57 (5): 847–856. PMID 10779366.
• Billups D, Hanley JG, Orme M, et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B". J. Neurosci. 20 (23): 8643–8650. doi:10.1523/jneurosci.20-23-08643.2000. PMC 6773065. PMID 11102469.
• Wang QW, Li ZW, Wang F, Yang JQ (2002). "Modulation by divalent cations of GABA rho 1 receptor from human retina expressed in Xenopus oocytes". Biomed. Environ. Sci. 14 (4): 269–277. PMID 11862606.
• Sedelnikova A, Weiss DS (2002). "Phosphorylation of the recombinant rho1 GABA receptor". Int. J. Dev. Neurosci. 20 (3–5): 237–246. doi:10.1016/S0736-5748(02)00037-0. PMID 12175859. S2CID 54402119.
• Torres VI, Weiss DS (2003). "Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening". J. Biol. Chem. 277 (46): 43741–43748. doi:10.1074/jbc.M202007200. PMID 12226075.
• Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". J. Biol. Chem. 278 (8): 6128–6135. doi:10.1074/jbc.M205162200. PMID 12431995.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Boué-Grabot E, Emerit MB, Toulmé E, et al. (2004). "Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels". J. Biol. Chem. 279 (8): 6967–6975. doi:10.1074/jbc.M307772200. PMID 14660627.
• Martínez-Torres A, Miledi R (2004). "A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism". Arch. Med. Res. 35 (3): 194–198. doi:10.1016/j.arcmed.2003.12.002. PMID 15163459.
• Sedelnikova A, Smith CD, Zakharkin SO, et al. (2005). "Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model". J. Biol. Chem. 280 (2): 1535–1542. doi:10.1074/jbc.M409908200. PMID 15548535.
• Song XQ, Meng F, Ramsey DJ, et al. (2006). "The GABA rho1 subunit interacts with a cellular retinoic acid binding protein in mammalian retina". Neuroscience. 136 (2): 467–475. doi:10.1016/j.neuroscience.2005.08.018. PMID 16198491. S2CID 37043103.

External links

• GABRR1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.