GLRB

"GLRB" is also the ICAO code for Roberts International Airport near Monrovia, Liberia.

GLRB
Identifiers
Aliases	GLRB, HKPX2, glycine receptor beta
External IDs	OMIM: 138492; MGI: 95751; HomoloGene: 20224; GeneCards: GLRB; OMA:GLRB - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q32.1 Start 157,076,125 bp End 157,172,090 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 E3|3 35.71 cM Start 80,750,906 bp End 80,820,967 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole Brodmann area 10 middle frontal gyrus lateral nuclear group of thalamus pons paraflocculus of cerebellum Brodmann area 23 dorsolateral prefrontal cortex endothelial cell primary visual cortex Top expressed in lateral geniculate nucleus mammillary body pontine nuclei medial vestibular nucleus deep cerebellar nuclei lobe of cerebellum lateral hypothalamus dorsal tegmental nucleus cerebellar vermis lateral septal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycine binding protein binding extracellularly glycine-gated ion channel activity chloride channel activity extracellular ligand-gated ion channel activity extracellularly glycine-gated chloride channel activity ion channel activity transmembrane signaling receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component cytoplasm integral component of membrane postsynaptic membrane cell projection membrane synapse chloride channel complex glycine-gated chloride channel complex cell junction dendrite integral component of plasma membrane plasma membrane GABA-ergic synapse glycinergic synapse neuron projection Biological process response to amino acid startle response protein heterooligomerization regulation of membrane potential gamma-aminobutyric acid receptor clustering chloride transmembrane transport nervous system development acrosome reaction neuromuscular process righting reflex chloride transport neuropeptide signaling pathway visual perception adult walking behavior ion transport synaptic transmission, glycinergic excitatory postsynaptic potential chemical synaptic transmission ion transmembrane transport signal transduction nervous system process regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2743 14658 Ensembl ENSG00000109738 ENSMUSG00000028020 UniProt P48167 P48168 RefSeq (mRNA) NM_000824 NM_001166060 NM_001166061 NM_001281969 NM_010298 NM_001345955 NM_001345956 NM_001345957 NM_001345958 NM_001345959 NM_001345996 RefSeq (protein) NP_000815 NP_001159532 NP_001159533 NP_001268898 NP_001332884 NP_001332885 NP_001332886 NP_001332887 NP_001332888 NP_001332925 NP_034428 Location (UCSC) Chr 4: 157.08 – 157.17 Mb Chr 3: 80.75 – 80.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Glycine receptor subunit beta is a protein that in humans is encoded by the GLRB gene.

The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM]

See also

• Glycine receptor

Further reading

• Meyer G, Kirsch J, Betz H, Langosch D (1995). "Identification of a gephyrin binding motif on the glycine receptor beta subunit". Neuron. 15 (3): 563–72. doi:10.1016/0896-6273(95)90145-0. PMID 7546736. S2CID 10164739.
• Sarang SS, Miller GW, Grant DF, Schnellmann RG (1999). "Expression and localization of the neuronal glycine receptor beta-subunit in human, rabbit and rat kidneys". Nephron. 82 (3): 254–60. doi:10.1159/000045410. PMID 10395998. S2CID 382638.
• Rees MI, Lewis TM, Kwok JB, et al. (2002). "Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB)". Hum. Mol. Genet. 11 (7): 853–60. doi:10.1093/hmg/11.7.853. PMID 11929858.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chen Z, Dillon GH, Huang R (2004). "Molecular determinants of proton modulation of glycine receptors". J. Biol. Chem. 279 (2): 876–83. doi:10.1074/jbc.M307684200. PMID 14563849.
• Burzomato V, Groot-Kormelink PJ, Sivilotti LG, Beato M (2004). "Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation". Recept. Channels. 9 (6): 353–61. doi:10.3109/714041016. PMID 14698963.
• Harvey K, Duguid IC, Alldred MJ, et al. (2004). "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering" (PDF). J. Neurosci. 24 (25): 5816–26. doi:10.1523/JNEUROSCI.1184-04.2004. PMC 6729214. PMID 15215304.
• Grudzinska J, Schemm R, Haeger S, et al. (2005). "The beta subunit determines the ligand binding properties of synaptic glycine receptors". Neuron. 45 (5): 727–39. doi:10.1016/j.neuron.2005.01.028. PMID 15748848. S2CID 2778607.

External links

• GLRB+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.