PBX2

PBX2
Identifiers
Aliases	PBX2, G17, HOX12, PBX2MHC, PBX homeobox 2
External IDs	OMIM: 176311; MGI: 1341793; HomoloGene: 48115; GeneCards: PBX2; OMA:PBX2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.32 Start 32,184,733 bp End 32,190,202 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 B1 Start 34,810,240 bp End 34,816,374 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland granulocyte right ovary spleen body of uterus Pituitary Gland left ovary anterior pituitary left uterine tube Top expressed in genital tubercle tail of embryo granulocyte mandibular prominence maxillary prominence somite saccule germ layer ectoderm otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding transcription factor binding chromatin binding protein binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus transcription regulator complex Biological process proximal/distal pattern formation regulation of transcription, DNA-templated embryonic limb morphogenesis transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5089 18515 Ensembl ENSG00000224952 ENSG00000237344 ENSG00000236353 ENSG00000232005 ENSG00000225987 ENSG00000206315 ENSG00000204304 ENSMUSG00000034673 UniProt P40425 O35984 RefSeq (mRNA) NM_002586 NM_017463 RefSeq (protein) NP_002577 NP_059491 Location (UCSC) Chr 6: 32.18 – 32.19 Mb Chr 17: 34.81 – 34.82 Mb PubMed search
Wikidata
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Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.

Function

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.

Interactions

PBX2 has been shown to interact with HOXA9.

Further reading

• Monica K, Galili N, Nourse J, Saltman D, Cleary ML (Dec 1991). "PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1". Molecular and Cellular Biology. 11 (12): 6149–57. doi:10.1128/mcb.11.12.6149. PMC 361792. PMID 1682799.
• Aguado B, Campbell RD (Feb 1995). "The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein". Genomics. 25 (3): 650–9. doi:10.1016/0888-7543(95)80007-9. PMID 7759099.
• Lu Q, Wright DD, Kamps MP (Jun 1994). "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation". Molecular and Cellular Biology. 14 (6): 3938–48. doi:10.1128/mcb.14.6.3938. PMC 358760. PMID 7910944.
• Katsanis N, Fitzgibbon J, Fisher EM (Jul 1996). "Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci". Genomics. 35 (1): 101–8. doi:10.1006/geno.1996.0328. PMID 8661110.
• Berthelsen J, Zappavigna V, Mavilio F, Blasi F (Mar 1998). "Prep1, a novel functional partner of Pbx proteins". The EMBO Journal. 17 (5): 1423–33. doi:10.1093/emboj/17.5.1423. PMC 1170490. PMID 9482739.
• Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. doi:10.1128/MCB.19.4.3051. PMC 84099. PMID 10082572.
• Fujino T, Yamazaki Y, Largaespada DA, Jenkins NA, Copeland NG, Hirokawa K, Nakamura T (Jul 2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes". Experimental Hematology. 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.
• Brake RL, Kees UR, Watt PM (May 2002). "A complex containing PBX2 contributes to activation of the proto-oncogene HOX11". Biochemical and Biophysical Research Communications. 294 (1): 23–34. doi:10.1016/S0006-291X(02)00426-6. PMID 12054735.
• Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T (Jun 2003). "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene". Blood. 101 (12): 4748–56. doi:10.1182/blood-2002-02-0380. PMID 12609849.
• Longobardi E, Blasi F (Oct 2003). "Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation". The Journal of Biological Chemistry. 278 (40): 39235–41. doi:10.1074/jbc.M304704200. PMID 12871956.
• Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L (Dec 2003). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Research. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.

External links

• PBX2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.