Agnes Baffoe-Bonnie
Holy Family University, Biology, Faculty Member
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European Urology Supplements, Volume 5, Issue 2, Pages 164, April 2006, Authors:S. Pakkanen; A. Baffoe-Bonnie; M. Matikainen; P. Koivisto; T. Tammela; O. Liang; BW Joan; J. Schleutker. Journal Home, Register or Login: Password: Auto-Login... more
European Urology Supplements, Volume 5, Issue 2, Pages 164, April 2006, Authors:S. Pakkanen; A. Baffoe-Bonnie; M. Matikainen; P. Koivisto; T. Tammela; O. Liang; BW Joan; J. Schleutker. Journal Home, Register or Login: Password: Auto-Login [Reminder]. ...
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... J Med Genet 43(1):8490 Eldon BJ, Jonsson E, Tomasson J, Tryggvadottir L, Tulinius H (2003) Familial risk of prostate cancer in Iceland. ... Cancer Res 67(7):29512956 Severi G, Hayes VM,Padilla EJ, English DR, Southey MC, Sutherland... more
... J Med Genet 43(1):8490 Eldon BJ, Jonsson E, Tomasson J, Tryggvadottir L, Tulinius H (2003) Familial risk of prostate cancer in Iceland. ... Cancer Res 67(7):29512956 Severi G, Hayes VM,Padilla EJ, English DR, Southey MC, Sutherland RL, Hopper JL, Giles GG. ...
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In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome-wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families.... more
In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome-wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families. Altogether 87 DNA samples were genotyped from 13 families. Logarithm-of-odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown. The highest LOD scores in the affected-only analyses were found at 11q14, where the two-point LOD score was 2.97 (theta = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non-parametric-linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25-26, with a two-point LOD score of 2.57 (theta = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02). The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.
Research Interests: Epidemiology, Nonparametric Statistics, Family, Prostate Cancer, Finland, and 15 moreHumans, Female, Male, Polymerase Chain Reaction, Cohort Study, Genetic determinism, Prostate, Genetic linkage analysis, Clinical Sciences, Aged, Middle Aged, Human Genome, Genetic Susceptibility, Paediatrics and reproductive medicine, and Macho
Research Interests: Genetics, Nephrology, Andrology, Humans, African American, and 15 moreMale, Genetic determinism, Genome, Pedigree, Genetic linkage analysis, African Americans, Clinical Sciences, Aged, Middle Aged, Human Genome, Gynecology, Interval, Genetic Susceptibility, Genetic Markers, and Paediatrics and reproductive medicine
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Research Interests: China, DNA, Hepatitis B, Humans, Hepatocellular Carcinoma, and 15 moreGlutathione, Detoxification, Genotype, Genetic variation, Glutathione Transferase, Codon, Hepatitis B virus, Bovine Serum Albumin, Case Control Study, Cross sectional Study, Genetic Susceptibility, Case Control Studies, Liver neoplasms, High risk, and Hepatitis B surface antigen
African American (AA) individuals are thought to develop multiple sclerosis (MS) less frequently than Caucasian American (CA) individuals. To compare the clinical characteristics of AA and CA patients with MS. The clinical features of MS... more
African American (AA) individuals are thought to develop multiple sclerosis (MS) less frequently than Caucasian American (CA) individuals. To compare the clinical characteristics of AA and CA patients with MS. The clinical features of MS were compared in a large retrospective cohort of AA (n = 375) and CA (n = 427) subjects. The proportion of women to men was similar in AA and CA subjects (81% [AA] vs 77% [CA]; p = 0.122). There were no differences in the proportions of subjects with relapsing-remitting, secondary progressive, primary progressive, and progressive relapsing MS. The median time to diagnosis was 1 year after symptom onset in AA subjects and 2 years after symptom onset in CA subjects (p = 0.0013). The age at onset was approximately 2.5 years later in AA than CA subjects (33.7 vs 31.1 years; p = 0.0001). AA subjects presented with multisite signs and symptoms at disease onset more often than CA subjects (p = 0.018). Clinical involvement restricted to the optic nerves and spinal cord (opticospinal MS) occurred in 16.8% of AA patients compared with 7.9% of CA patients (p < 0.001). Transverse myelitis also occurred more frequently in AA subjects (28 vs 18%; p = 0.001). Survival analysis revealed that AA subjects were at higher risk for development of ambulatory disability than CA subjects. After adjusting for baseline variations and differences in therapeutic interventions, AAs were at 1.67-fold greater risk for requiring a cane to ambulate than CA patients (p < 0.001). There was a trend suggesting that AAs were also at greater risk for development of wheelchair dependency (p = 0.099). Adjusted Cox proportional hazard models showed that this effect was in part attributable to the older age at onset in AAs (p < 0.001). Compared with multiple sclerosis (MS) in Caucasian Americans, African American patients with MS have a greater likelihood of developing opticospinal MS and transverse myelitis and have a more aggressive disease course.
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Research Interests: Genetics, Urology, Cancer, Prostate Cancer, Humans, and 8 moreUnited States, Male, The, Gene, Genetic linkage analysis, Gen, Genotype, and Prostatic neoplasms
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Research Interests: Genetics, Human Genetics, Complementary and Alternative Medicine, Prostate Cancer, Finland, and 14 moreHumans, Male, Cancer Diagnosis, Cluster Analysis, Family Health, Age Factors, Logistic Distribution, Cancer Registry, Age of Onset, Cohort Studies, Autosomal Dominant, Gene frequency, Prostatic neoplasms, and Paediatrics and reproductive medicine
In a recent genome-wide linkage (GWL) analysis of Finnish families at high risk for prostate cancer, we found two novel putative susceptibility loci at 3p25-p26 and 11q14. Here, we report the fine-mapping of these two critical regions at... more
In a recent genome-wide linkage (GWL) analysis of Finnish families at high risk for prostate cancer, we found two novel putative susceptibility loci at 3p25-p26 and 11q14. Here, we report the fine-mapping of these two critical regions at high resolution with 39 microsatellite markers in 16 families, including multiplex families that were not used in the GWL scan. The maximum multipoint HLOD was 3.39 at 3p26 and 1.42 at 11q14. The highest LOD scores were seen around markers D3S1270 and D3S4559 (alpha=0.89), covering approximately two megabases. The two known genes in this region CHL1 (cell adhesion molecule with homology to L1CAM) and CNTN6 (contactin 6) were screened for exonic mutations in the families showing the strongest linkage, but no disease-segregating sequence variants were observed. The recombination map pointed to a region proximal to the area of best linkage, suggesting that more genes may need to be investigated as candidates. These results provide strong evidence for the existence of a prostate cancer susceptibility gene at 3p26 in Finnish prostate cancer families. This locus has not been strongly linked with hereditary prostate cancer in other populations. However, the mildly positive 3p LOD scores in a recent GWL analysis of patients from the United States suggest that the locus may also be important in other populations.
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Research Interests: Genetics, Human Genetics, Complementary and Alternative Medicine, International Cooperation, Humans, and 14 moreFemale, Male, Pedigree, Genetic linkage analysis, African Americans, Aged, Middle Aged, Human Genome, Family Health, Genotype, European Continental Ancestry Group, genetic heterogeneity, Prostatic neoplasms, and Paediatrics and reproductive medicine
Research Interests: Genetics, Human Genetics, Complementary and Alternative Medicine, Family, Prostate Cancer, and 15 morePublic Health, Disease susceptibility, Humans, Male, Genetic linkage analysis, Aged, Middle Aged, Human Genome, Carcinoma, Interaction effect, Epidemiologic Studies, Genetic Markers, Linkage Analysis, Prostatic neoplasms, and Paediatrics and reproductive medicine
Research Interests: Genetics, Human Genetics, Complementary and Alternative Medicine, Prostate Cancer, Finland, and 13 moreMultiple testing, Humans, Haplotypes, Male, Population Control, Genotype, Single Nucleotide Polymorphism, Linkage Disequilibrium, Genetic Markers, DNA mutational analysis, Gene frequency, Prostatic neoplasms, and Paediatrics and reproductive medicine
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Breast cancer and prostate cancer are the most commonly occurring cancers in females and males, respectively. The objective of this project was to test the hypothesis that breast cancer in females and prostate cancer in males represent... more
Breast cancer and prostate cancer are the most commonly occurring cancers in females and males, respectively. The objective of this project was to test the hypothesis that breast cancer in females and prostate cancer in males represent homologous cancers that may be controlled by one or more common unidentified genes that may explain some of the observed familial aggregation. We modeled the transmission of a breast-prostate cancer phenotype in 389 pedigrees ascertained through a breast cancer proband drawn from the Icelandic Cancer Registry. Assuming that age at diagnosis of this combined phenotype followed a logistic distribution, segregation analyses were performed to evaluate residual parental effects, a sibship covariate, and a dichotomous cohort effect. The most parsimonious model was a Mendelian codominant model, which could partly explain the familial aggregation of both cancers. Inheritance of a putative high-risk allele (A) predicted gender-specific mean ages of onset for females as 53.8 years, 59.7 years, and 65.6 years for the putative AA, AB, and BB genotypes, respectively. Similarly, the predicted means were 73.7 years, 75.6 years, and 78.3 years, respectively, among males. Under this codominant model, the lifetime risk of a woman being affected was 19% by age 80 years. This implies that when prostate cancer among male relatives of breast cancer probands (unselected for family history or early-onset disease) is considered a pleiotrophic effect of the same gene that increases the risk for breast cancer, women are predicted to have a less than 1 in 5 risk of developing breast cancer when they carry the putative high-risk allele. However, this is a higher risk than in the general Icelandic population. Our results suggest that BRCA2 mutations alone are inadequate to explain all of the excess clustering of prostate cancer cases in families of breast cancer probands, and that additional genes conferring excess risk to both breast and prostate cancer may exist in this population.
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The African American Hereditary Prostate Cancer (AAHPC) Study is an ongoing multicenter genetic linkage study organized by Howard University and the National Human Genome Research Institute (NHGRI), with support from the Office for... more
The African American Hereditary Prostate Cancer (AAHPC) Study is an ongoing multicenter genetic linkage study organized by Howard University and the National Human Genome Research Institute (NHGRI), with support from the Office for Research on Minority Health and the National Cancer Institute. The goals of the study are to: (i) look for evidence of involvement of chromosome 1q24-25 (HPC1) in African American men with hereditary prostate cancer (HPC) and (ii) conduct a genome-wide search for other loci associated with HPC in African American men. To accomplish these goals, a network has been established including Howard University, the NHGRI, and six Collaborative Recruitment Centers (CRCs). The CRCs are responsible for the identification and enrollment of 100 African American families. To date, 43 families have been enrolled. Recruitment strategies have included mass media campaigns, physician referrals, community health-fairs/prostate cancer screenings, support groups, tumor registries, as well as visits to churches, barber shops, and universities. By far, the most productive recruitment mechanisms have been physician referrals and tumor registries, yielding a total of 35 (81%) families. Approximately 41% (n = 3400) of probands initially contacted by phone or mail expressed interest in participating; the families of 2% of these met the eligibility criteria, and 75% of those families have been enrolled in the study, indicating a 0.5% recruitment yield (ratio of participants to contacts). As the first large-scale genetic linkage study of African Americans, on a common disease, the challenges and successes of the recruitment process for the AAHPC Study should serve to inform future efforts to involve this population in similar studies.
Research Interests: Genetics, Cancer, Family, Community Health, Prostate Cancer, and 15 moreMass media, Methods, Humans, African American, Male, Genetic linkage analysis, African Americans, Human Genome, Support Group, National Cancer Institute, Large Scale, Clinical Trials as Topic, Patient selection, Prostatic neoplasms, and Medical and Health Sciences
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Multipoint linkage analysis was used to screen for evidence of linkage between alcoholism and five alcoholism-related quantitative traits. The results suggest that a susceptibility locus that influences monoamine oxidase activity and P300... more
Multipoint linkage analysis was used to screen for evidence of linkage between alcoholism and five alcoholism-related quantitative traits. The results suggest that a susceptibility locus that influences monoamine oxidase activity and P300 amplitude at the Pz lead, and increases the risk of alcohol dependence may be linked to markers in the 12q24 region. Furthermore, the susceptibility for alcoholism may be associated with allele 3 (allele size 144) of D12S392.