In breast carcinoma, carbohydrate antigen 15-3 (CA 15-3), a mucin component, is the most important and commonly used tumor marker. It is a transmembrane glycoprotein containing a large extracellular domain of 69 amino acids. Several... more
In breast carcinoma, carbohydrate antigen 15-3 (CA 15-3), a mucin component, is the most important and commonly used tumor marker. It is a transmembrane glycoprotein containing a large extracellular domain of 69 amino acids. Several studies suggested that its evaluation could provide valuable clinical information. Assessment of CA 15-3 can also be useful during treatment of Breast cancer as well as to detect recurrence following primary treatment. CA 15-3 is a breast-cancer-associated antigen defined by reactivity with two monoclonal antibodies, DF3 (raised against a membrane-enriched fraction of human breast cancer) and 115D8 (raised against antigens of human milk fat globule membrane). The main clinical application of CA 15-3 suggested being in monitoring the response to the treatment and gives reliable information on the recurrence of the disease. The aim of present study is to assess CA 15-3 in patients with breast carcinoma and its usefulness in monitoring and therapy. Serum sa...
