De mogelijkheid om geluiden te horen en te verwerken is cruciaal voor zowel jong als oud. Wanneer volwassenen ouder worden, vermindert de kwaliteit van het geluid en in het bijzonder van de spraak die men waarneemt. Als het gehoorverlies... more
De mogelijkheid om geluiden te horen en te verwerken is cruciaal voor zowel jong als oud. Wanneer volwassenen ouder worden, vermindert de kwaliteit van het geluid en in het bijzonder van de spraak die men waarneemt. Als het gehoorverlies te ernstig wordt, kan sociale isolatie optreden. Voor kinderen betekent dit verlies een obstakel voor een normale spraak- en taalontwikkeling. Vooral voor hen is het belangrijk om dit gehoorverlies zo vroeg mogelijk op te sporen en er gepast op te reageren. Om deze reden zou het gehoor van alle pasgeborenen moeten worden gecontroleerd. Als het resultaat van deze 'screening' niet op een normaal gehoor wijst, is meer gedetailleerde gehoorschatting nodig. Het probleem hier is wel dat de standaard gebruikte gedragstesten niet kunnen gebruikt worden. Daarom dat deze testen moet terugvallen op objectieve fysiologische technieken die niet beïnvloed worden door slaap of sedatie. De laatste decennia werd er gefocust op een techniek die gebruikt maakt...
Research Interests: Algorithms, Biomedical Engineering, Principal Component Analysis, Independent Component Analysis, Electroencephalography, and 7 moreHumans, Electroencephalogram, Reproducibility of Results, Auditory evoked Potentials, Sensitivity and Specificity, Electrical And Electronic Engineering, and Clinical Application
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Introduction Cortical auditory evoked potentials (CAEPs) are influenced by the characteristics of the stimulus, including level and hearing aid gain. Previous studies have measured CAEPs aided and unaided in individuals with normal... more
Introduction Cortical auditory evoked potentials (CAEPs) are influenced by the characteristics of the stimulus, including level and hearing aid gain. Previous studies have measured CAEPs aided and unaided in individuals with normal hearing. There is a significant difference between providing amplification to a normal-hearing or a hearing-impaired person. This study investigates this difference, and the effects of stimulus signal-to-noise ratio (SNR) and audibility on the CAEP amplitude in a population with hearing loss. Methods Twelve normal-hearing participants and twelve participants with a hearing loss participated in this study. Three speech sounds /m/, /g/, and /t/ were presented in the free field. Unaided stimuli were presented at 55, 65, and 75 dB SPL, and aided stimuli at 55 dB SPL with three different gains in steps of 10 dB. CAEPs were recorded and their amplitudes analyzed. Stimulus SNR and audibility were determined. Results No significant effect of stimulus level or hea...
The application of auditory steady-state responses (ASSRs) is an objective and frequency specific technique to assess reliable hearing thresholds at audiometric fre- quencies. Unfortunately, the duration of ASSR measure- ment can be long,... more
The application of auditory steady-state responses (ASSRs) is an objective and frequency specific technique to assess reliable hearing thresholds at audiometric fre- quencies. Unfortunately, the duration of ASSR measure- ment can be long, which is unpractical for wide scale clin- ical application. Therefore, we propose independent com- ponent analysis (ICA) as a tool to improve the ASSR de- tection in recorded multi-channel electroencephalogram (EEG) data obtained at high intensities. We conclude that ICA is able to reduce measurement duration significantly. For a multi-channel implementation, near-optimal perfor- mance is obtained with five-channel recordings. A pro- posal for a generative model is suggested. This model may provide the ability to explain some observed char- acteristics of the ICA-ASSR problem.
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To determine the influence of auditory stimuli spectral characteristics on cortical auditory evoked potentials (CAEPs). CAEPs were obtained from 15 normal-hearing adults in response to six multitone (MT), four pure-tone (PT), and two... more
To determine the influence of auditory stimuli spectral characteristics on cortical auditory evoked potentials (CAEPs). CAEPs were obtained from 15 normal-hearing adults in response to six multitone (MT), four pure-tone (PT), and two narrowband noise stimuli. The sounds were presented at 10, 20, and 40 dB above threshold, which were estimated behaviorally beforehand. The root mean square amplitude of the CAEP and the detectability of the response were calculated and analyzed. Amplitudes of the CAEPs to the MT were significantly larger compared with PT for stimuli with frequencies centered around 1, 2, and 4 kHz, whereas no significant difference was found for 0.5 kHz. The objective detection score for the MT was significantly higher compared with the PT. For the 1- and 2-kHz stimuli, the CAEP amplitudes to narrowband noise were not significantly different than those evoked by PT. The study supports the notion that spectral complexity, not just bandwidth, has an impact on the CAEP am...
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Research Interests: Algorithms, Auditory Perception, Electroencephalography, Multidisciplinary, Humans, and 14 moreFemale, Male, Young Adult, Artifacts, Electroencephalogram, Steady state, Theoretical Models, Adult, Auditory Threshold, Auditory evoked Potentials, Auditory Cortex, Electrodes, Brain stem, and Acoustic Stimulation
Research Interests: Cognitive Science, Signal Processing, Auditory Perception, Patient Safety, Electronics, and 18 moreElectroencephalography, Software, Humans, Data Collection, Real Time, Evaluation Studies, Adult, Objective, Auditory Threshold, Auditory evoked Potentials, Auditory Cortex, Reference Values, Statistical Methods for Neuroscience, Idle channel Measurement, Neurosciences, Functional Laterality, Acoustic Stimulation, and Hearing Threshold
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Research Interests: Algorithms, Biomedical Engineering, Principal Component Analysis, Independent Component Analysis, Electroencephalography, and 7 moreHumans, Electroencephalogram, Reproducibility of Results, Auditory evoked Potentials, Sensitivity and Specificity, Electrical And Electronic Engineering, and Clinical Application
Research Interests: Time Use, Software, Fourier Analysis, Humans, Female, and 18 moreMale, Infant, Bit Error Rate, Artifacts, Clinical Sciences, Newborn Infant, Aged, Middle Aged, Adult, Hearing Impaired, Reproducibility of Results, Auditory Threshold, Statistical Test, Object Detection, Detection Rate, Neurosciences, Weighted Averaging, and Acoustic Stimulation
The first aim of this study is to validate the theoretical framework of least-squares (LS) deconvolution on experimental data. The second is to investigate the waveform morphology of the cortical auditory evoked potential (CAEP) for five... more
The first aim of this study is to validate the theoretical framework of least-squares (LS) deconvolution on experimental data. The second is to investigate the waveform morphology of the cortical auditory evoked potential (CAEP) for five stimulus onset-asynchronies (SOAs) and effects of alternating stimulus frequency in normally hearing adults. Eleven adults (19-55 years) with normal hearing were investigated using tone-burst stimuli of 500 and 2000 Hz with SOAs jittered around 150, 250, 450, and 850 ms in a paired-interval paradigm with fixed or alternating stimulus frequency. The LS deconvolution technique disentangled the overlapping responses, which then provided the following insights. The CAEP amplitude reached a minimum value for SOAs jittered around 450 ms, in contrast with significantly larger amplitudes for SOAs jittered around 150 and 850 ms. Despite this, longer latencies of N1 and P2 consistently occurred for decreasing SOAs. Alternating stimulus frequency significantly...
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Research Interests: Prediction, Synchronization, Humans, Female, Male, and 22 moreReaction Time, Young Adult, Infant, ENT, Hearing Loss, Deafness, Data Fitting, Clinical Sciences, Newborn Infant, Adult, Hearing Impaired, Group, Age Factors, Auditory Threshold, Auditory evoked Potentials, Audiology and Neurotology, Latency, Gestational Age, Reference Values, Neurosciences, Synchronisation, and Child preschool
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Hearing threshold estimation based on cortical auditory evoked potentials (CAEPs) has been applied for some decades. However, available research is scarce evaluating the accuracy of this technique with an automated paradigm for the... more
Hearing threshold estimation based on cortical auditory evoked potentials (CAEPs) has been applied for some decades. However, available research is scarce evaluating the accuracy of this technique with an automated paradigm for the objective detection of CAEPs. To determine the difference between behavioral and CAEP thresholds detected using an objective paradigm based on the Hotelling's T² statistic. To propose a decision tree to choose the next stimulus level in a sample of hearing-impaired adults. This knowledge potentially could increase the efficiency of clinical hearing threshold testing. Correlational cohort study. Thresholds obtained behaviorally were compared with thresholds obtained through cortical testing. Thirty-four adults with hearing loss participated in this study. For each audiometric frequency and each ear, behavioral thresholds were collected with both pure-tone and 40-msec tone-burst stimuli. Then, corresponding cortical hearing thresholds were determined. A...
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Hearing threshold estimation based on cortical auditory evoked potentials (CAEPs) has been applied for some decades. However, available research is scarce evaluating the accuracy of this technique with an automated paradigm for the... more
Hearing threshold estimation based on cortical auditory evoked potentials (CAEPs) has been applied for some decades. However, available research is scarce evaluating the accuracy of this technique with an automated paradigm for the objective detection of CAEPs. To determine the difference between behavioral and CAEP thresholds detected using an objective paradigm based on the Hotelling's T² statistic. To propose a decision tree to choose the next stimulus level in a sample of hearing-impaired adults. This knowledge potentially could increase the efficiency of clinical hearing threshold testing. Correlational cohort study. Thresholds obtained behaviorally were compared with thresholds obtained through cortical testing. Thirty-four adults with hearing loss participated in this study. For each audiometric frequency and each ear, behavioral thresholds were collected with both pure-tone and 40-msec tone-burst stimuli. Then, corresponding cortical hearing thresholds were determined. A...