Research Interests:
Research Interests: Medicine and Akademisyen
Research Interests:
Influenza viruses are members of the Orthomyxoviridae family, of which influenza A, B, and C viruses constitute three separate genera. Arterial thrombosis associated with H1N1 influenza A virus infection has rarely been reported. A... more
Influenza viruses are members of the Orthomyxoviridae family, of which influenza A, B, and C viruses constitute three separate genera. Arterial thrombosis associated with H1N1 influenza A virus infection has rarely been reported. A Turkish man aged 28 years was admitted to our emergency department with dyspnea, bilateral lower extremity insensitivity, and cold. He reported symptoms of fever, myalgia, and cough, which he had had for fifteen days before being admitted to our hospital. The patient was tested for pandemic influenza A (H1N1) virus using polymerase chain reaction (PCR) tests, which were positive. Abdominal computerized tomography with contrast revealed a large occlusive thrombus within the infrarenal aorta.
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Objective. Patients with chronic renal failure (CRF) have an increased risk of death from cardiovascular diseases. The metabolic syndrome is a common risk factor for cardiovascular diseases. In the present study, it was aimed to evaluate... more
Objective. Patients with chronic renal failure (CRF) have an increased risk of death from cardiovascular diseases. The metabolic syndrome is a common risk factor for cardiovascular diseases. In the present study, it was aimed to evaluate the frequency of metabolic syndrome using the National Cholesterol Education Program Adults Treatment Panel III (NCEP-ATP III) and the International Diabetes Federation (IDF) definitions in patients with end-stage CRF undergoing hemodialysis (HD). Materials and Methods. A total of 222 cases undergoing HD were enrolled in the study. After obtaining medical history and physical examination, blood samples were collected from each patient for the measurements of fasting blood glucose, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides. Results. Among HD patients evaluated according to both IDF and NCEP-ATP III definitions, the diagnosis of metabolic syndrome was confirmed by IDF in 56.5% of those fulfilling the criteria for NCEP-ATP III. Similarly, 86% of the undiagnosed patients according to NCEP-ATP III were confirmed by IDF definitions. The sensitivity and positive predictive value of NCEP-ATP III for metabolic syndrome were 81.25% and 64.8%, respectively. The area under the Receiver Operating Characteristic (ROC) curve for NECP-ATP III and IDF was 0.730. False-positive rate and probability ratio for NECP-ATP III were 0.352 and 2.49, respectively. In other words, among the patients who were diagnosed with metabolic syndrome according to NCEP-ATP III definitions, the proportion of subjects whose diagnosis was confirmed by IDF definitions was 2.49-fold higher than those with unconfirmed diagnosis. Conclusion. It is logical to evaluate patients with CRF for metabolic syndrome and cardiovascular risk factors at the time of diagnosis and regularly thereafter due to the high ratio of metabolic syndrome in this population.
Research Interests:
Department of Nephrology, Hatay Education and Research Hospital, Hatay, Turkey. Department of Neurology, Hatay Education and Research Hospital, Hatay, Turkey. Department of Radiology, Hatay Education and Research Hospital, Hatay, Turkey.... more
Department of Nephrology, Hatay Education and Research Hospital, Hatay, Turkey. Department of Neurology, Hatay Education and Research Hospital, Hatay, Turkey. Department of Radiology, Hatay Education and Research Hospital, Hatay, Turkey. Department of General Surgery, Private Academy Hospital, Hatay, Turkey. Department of Anesthesia and Reanimation, Hatay Education and Research Hospital, Hatay, Turkey.
Research Interests:
Introduction: Hemolytic uremic syndrome (HUS) is a clinical syndrome characterized by non-immune microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. In this study, we aimed to evaluate patients diagnosed with HUS... more
Introduction: Hemolytic uremic syndrome (HUS) is a clinical syndrome characterized by non-immune microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. In this study, we aimed to evaluate patients diagnosed with HUS in our clinic. Method: Patients who were diagnosed with HUS as clinic and laboratory between August 2012 and October 2017 were included in our nephrology clinic. Biochemistry, haemogram, ANA, anti-Ds DNA, p-ANCA, c-ANCA, anti-GBM antibody, C3, C4 of patients were studied. In some cases, ADAMTS13 was studied and renal biopsy was performed. The demographic features, clinics, and treatments of our cases were reviewed. Results: A total of 18 patients were enrolled in the study, the average age of the patients was 48.3 (21-82) and 10 of the cases were female and 8 of the cases were male. Among the etiologic causes of HUS in patients; the complement factor B mutation, complement factor H polymorphism, breast cancer, herbal medicine, infections and idiopathic were detected. Primer glomerulonephritis was detected in 6 cases of renal biopsy. Conclusion: Clinical and laboratory remission was obtained in 13 patients. End-stage renal failure developed in 3 of our patients.
Research Interests:
Research Interests:
Research Interests:
Background: Renal involvement in malignant patients may lead to kidney disease indirectly for a number of reasons, including direct metastasis or dehydration, hyperuricemia, and tumor lysis syndrome. We aimed to evaluate malignant... more
Background: Renal involvement in malignant patients may lead to kidney disease indirectly for a number of reasons, including direct metastasis or dehydration, hyperuricemia, and tumor lysis syndrome. We aimed to evaluate malignant patients who developed kidney disease in our study. Method: This study was performed in malignant patients who applied to the Kahramanmaras Necip Fazil City hospital between 2015-2017. Blood urea nitrogen, serum creatinine, uric acid, sodium, potassium, calcium, phosphorus, glucose, complete urine output and hemogram were noted in patients with kidney disease. Results: A total of 688 cancer patients were included in the study. 53.6% of the patients were female and 46.2% were male. The average age of the patients was found as 60.23±13.25 (21-94). Acute kidney injury was detected in %17,1. When the patients diagnosed with kidney disease were evaluated; serum uric acid levels were higher in 46.2% of patients, calcium-level was low in 7.7% of patients and high...
Research Interests:
1 NecipFazıl City Hospital, Clinic of Nephrology, Kahramanmaras, Turkey NecipFazıl City Hospital, Clinic of Internal Medicine, Kahramanmaras, Turkey Department of Nephrology, Cumhuriyet University, Sivas, Turkey Corresponding author:Can... more
1 NecipFazıl City Hospital, Clinic of Nephrology, Kahramanmaras, Turkey NecipFazıl City Hospital, Clinic of Internal Medicine, Kahramanmaras, Turkey Department of Nephrology, Cumhuriyet University, Sivas, Turkey Corresponding author:Can Huzmeli, NecipFazıl City Hospital, Clinic of Nephrology, Kahramanmaras, Turkey E-mail:chuzmeli@hotmail.com Received/Accepted: January 06, 2018 / January 23, 2018 Conflict of interest: There is not a conflict of interest.
Research Interests: Medicine and Hemodialysis
Parvovirus B19 is a small non-enveloped DNA virus that takes place in erythrovirus genus of parvoviridae family. Parvovirus B19 is primarily spread by respiratory secretions, blood transfusion, organ transplants and transplacental route.... more
Parvovirus B19 is a small non-enveloped DNA virus that takes place in erythrovirus genus of parvoviridae family. Parvovirus B19 is primarily spread by respiratory secretions, blood transfusion, organ transplants and transplacental route. Intrauterine ex, hydrops fetalis and congenital anemia may develop as a result of parvovirus infection, especially between weeks 20 and 24 of pregnant women. In this article, intrauterine exitus developed as a result of parvovirus infection, HELLP syndrome, anuric renal failure and IgA nephropathy diagnosed case is discussed with the literature.
Research Interests:
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and is responsible for 8–10% of patients with end-stage renal failure. The major extrarenal complications of ADPKD are cardiovascular... more
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and is responsible for 8–10% of patients with end-stage renal failure. The major extrarenal complications of ADPKD are cardiovascular abnormalities. Interrupted aortic arch (IAA) is a lethal congenital cardiac abnormality seen with a frequency of 3/1000000 births and is defined as a segment of the arcus aorta being atresic. In the literature, there are no any reports showing that polycystic kidney disease and interrupted aortic arch occur together. In this study, we present a rare case in which the patient has polycystic kidney disease and IAA together and discuss whether IAA is a complication of ADPKD.
Background: Many studies were carried out to investigate the relationship between single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene with obesity. However, little is known about the role of VDR gene polymorphism with... more
Background: Many studies were carried out to investigate the relationship between single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene with obesity. However, little is known about the role of VDR gene polymorphism with obesity in hemodialysis (HD) patients. Therefore, we aimed to investigate VDR gene TaqI, ApaI and FokI SNPs in overweight/obese HD patients. Methods: Seventy one normal weight and 68 overweight/obese HD patients were included in study. PCR-RFLP method was used for genotyping. Demographic and laboratory data obtained from medical records of patients. Results: For all three SNPs, no significant association was found between normal and overweight/obese patients (P>0.05). Lower HDL concentrations and higher levels of triglyceride (TG) and glucose were detected in the obese/overweight patients compared to normal weight (p<0.001 for HDL, and TG and p=0.023 for glucose). In obese/overweight patients, subjects with CC genotype of TaqI showed higher PT...
Amac: Bu calismanin amaci, gut artriti tanisi konan hastalarda kronik bobrek hastaligi (KBH) prevalansini saptamaktir. Yontem: Bu calismaya 2014 ile 2017 tarihleri arasinda gut artirti tanisi konan toplam 162 hasta alindi. Calismamiz... more
Amac: Bu calismanin amaci, gut artriti tanisi konan hastalarda kronik bobrek hastaligi (KBH) prevalansini saptamaktir. Yontem: Bu calismaya 2014 ile 2017 tarihleri arasinda gut artirti tanisi konan toplam 162 hasta alindi. Calismamiz retrospektif bir calismadir. Glomeruler filtrasyon hizi Modification of Renal Disease (MDRD) yontemiyle hesaplandi. Bulgular: Hastalarin yas ortalamasi 59,64±14,54 (18-93) olarak bulundu. Hastalarin cogunlugu erkekti. Hastalarin ortalama urik asit seviyeleri 9,07mg/dl±1,75(4-14,7) olarak bulundu. Gut artritli bireylerin % 39,5'i (64) KBH evre 3-5, % 46.9’u (46) hipertansiyon, % 18,5 (30) diabetes mellitus, % 14,2’sinde (23) koroner arter hastaligi mevcuttu. Hastalarin %33,3'u KBY evre 2 olarak saptandi. Ultrasonu yapilmis 85 hastanin 22'sinde nefrolitiyazis vardi. Hastalarin 36'sinda diuretik kullanimi tespit edildi. Diyetisyenden istenilen konsultasyon orani %41,4 idi. Sonuclar: KBH ’de hiperurisemi ve hipertansiyon sikligi yuksektir. H...
Purpose: We investigated the influence of the vitamin D receptor gene TaqI (rs731236), ApaI (rs7975232), and FokI (rs2228570) polymorphisms in arteriovenous fistula failure in hemodialysis patients. Methods: This study was carried out... more
Purpose: We investigated the influence of the vitamin D receptor gene TaqI (rs731236), ApaI (rs7975232), and FokI (rs2228570) polymorphisms in arteriovenous fistula failure in hemodialysis patients. Methods: This study was carried out with 54 patients who experienced two or more fistula failures in the late period after arteriovenous fistula operation and 58 control patients with no history of arteriovenous fistula failure in 3 years or longer. The polymerase chain reaction–restriction fragment length polymorphism method was used to determine the vitamin D receptor TaqI, FokI, and ApaI polymorphisms. Results: For vitamin D receptor gene TaqI and Fok1 polymorphisms, no significant association was found between the two groups ( p > 0.05). However, a statistically significant association was determined for ApaI polymorphism between the two groups ( p = 0.02). In patients, ApaI AA, AC, and CC genotype frequencies were found as 21 (38.9%), 32 (59.3%), and 1 (1.8%), respectively. Howev...
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
C3 glomerulopati (C3G), kompleman aktivasyonunun anormal kontrolu ile olusan bir grup bobrek hastaligini kapsayan yakin zamanda tanimlanmis bir hastaliktir. C3G glomerullerde immunoglobulin birikiminin trace ve yoklugu ile dominant olarak... more
C3 glomerulopati (C3G), kompleman aktivasyonunun anormal kontrolu ile olusan bir grup bobrek hastaligini kapsayan yakin zamanda tanimlanmis bir hastaliktir. C3G glomerullerde immunoglobulin birikiminin trace ve yoklugu ile dominant olarak kompleman C3 birikimi ile karakterizedir. C3G C3 glomerulonefrit (C3GN) ve Dens Deposit Hastaligi (DDD) diye iki grup hastaliktan olusmaktadir. DDD ve C3GN nadir gorulmektedir ve her iki hastalik hem cocuklarda hemde eriskinlerde gorulmektedir. C3G spesifik tedavisinde, plazmaferez, immunsupresif tedavi ve kompleman inhibitorlerini icermektedir.
Research Interests:
Renal infarction is a clinical condition which is caused by renal artery occlusion and leads to permanent renal parenchymal damage. In the literature, there are generally case reports on this subject, and few studies that include a large... more
Renal infarction is a clinical condition which is caused by renal artery occlusion and leads to permanent renal parenchymal damage. In the literature, there are generally case reports on this subject, and few studies that include a large group of patients. Therefore, we aimed to present the data of a large group of patients who were diagnosed with acute renal infarction in our country in this retrospective study. The data of patients who were diagnosed with acute renal infarction according to clinical and radiological findings in Turkey in the last 3 years were examined. For this purpose, we contacted with more than 40 centers in 7 regions and obtained support from clinically responsible persons. Demographic data of patients, laboratory data at the time of diagnosis, tests performed for etiologic evaluation, given medications, and patients' clinical status during follow-up were obtained from databases and statistical analysis was performed. One-hundred and twenty-one patients we...
Research Interests:
Background: The purpose of this study was to investigate the relationship between the genetic mutations, which are frequently detected and known to cause familial Mediterranean fever (FMF) disease, with ABO blood groups.Methods: There... more
Background: The purpose of this study was to investigate the relationship between the genetic mutations, which are frequently detected and known to cause familial Mediterranean fever (FMF) disease, with ABO blood groups.Methods: There were 271 patients with FMF diagnosis and 271 healthy control subject enrolled in the study. The medical files of each case were screened retrospectively and demographic characteristics, genetic mutations, and ABO blood groups were recorded.Results: No statistically significant difference was detected between the two groups with respect to their gender and age (p>0/05). When patient and healthy control groups were compared based on ABO blood groups, the study groups were observed to differ significantly with respect to B blood group (p=0.008). In the patient group, a considerable relationship could not have been found when the gene mutations were compared based on blood groups, either for E148Q (n=64) and M694V (n=142) genes (p>0.05). However, a c...
Research Interests:
Research Interests:
Primary glomerulopathies are those disorders that affect glomerular structure, function, or both in the absence of a multisystem disorder. We aimed to evaluate the frequency of MEFV gene mutation to show possible coexistence of FMF in... more
Primary glomerulopathies are those disorders that affect glomerular structure, function, or both in the absence of a multisystem disorder. We aimed to evaluate the frequency of MEFV gene mutation to show possible coexistence of FMF in patients diagnosed with biopsy-proven primary glomerulonephritis (GN). A total of 64 patients with biopsy-proven primary GN were included in the study. MEFV gene mutations examined retrospectively. The mean age of patients was 39.6 ± 13.4 (range 18-69), 35 of patients were female and 29 of patients were male. Of the 64 patients, 17 were mesangial proliferative glomerulonephritis (MsPGN), 15 were IgA nephropathy (IgAN), 12 were membranous glomerulonephritis (MGN), 11 were focal segmental glomerulosclerosis (FSGS), three were membranous proliferative glomerulonephritis (MPGN), three were immune complex glomerulonephritis (ICGN), two were minimal change disease (MCD), and one was IgM nephropathy (IgMN). MEFV gene mutation was detected in 35.9% (23) of the...
Research Interests:
Cytomegalovirus (CMV) is a DNA virus belonging to herpesviridea family. CMV infections are seen at all age groups all through the world. Its seroprevalence is 50% in developed countries and 40- 100% in developing countries. In seropostive... more
Cytomegalovirus (CMV) is a DNA virus belonging to herpesviridea family. CMV infections are seen at all age groups all through the world. Its seroprevalence is 50% in developed countries and 40- 100% in developing countries. In seropostive cases, the disease develops as result of reactivation following a treatment with immunosuppressive.Hemolytic uremic syndrome (HUS) is defined by the triad of mechanical hemolytic anemia,thrombocytopenia and renal impairment. Atypical HUS (aHUS) defines non Shigatoxin- HUSand a primary disease due to a disorder in complement alternative pathway regulation.In the present paper, a 60 years old case undergoing plasma exchange for aHUS and found to have CMV pneumonia during follow-up is presented.
Research Interests:
The tumor lysis syndrome (TLS) is a collection of metabolic abnormalities that occur in consequence of the release of intracellular contents following lysis of tumor cells. TLS occurs spontaneously or after chemotherapy. Spontaneous TLS... more
The tumor lysis syndrome (TLS) is a collection of metabolic abnormalities that occur in consequence of the release of intracellular contents following lysis of tumor cells. TLS occurs spontaneously or after chemotherapy. Spontaneous TLS is uncommon occurrence in multiple myeloma (MM). We define a case of a 70-year-old woman patient who was found to have MM with spontaneous TLS, following a compression fracture of the T-12 vertebrae. While serum uric acid and phosphorous levels were high, low calcium levels were identified. There were also acute kidney injury and metabolic acidosis. Upon the diagnosis of TLS, she was treated with hydration, allopurinol, sodium bicarbonate, and calcium gluconate. The improvement of her laboratory data was observed. We submitted this case in order to draw attention to the presentation of MM with spontaneous TLS.
Research Interests:
Research Interests:
Research Interests:
We aimed to investigate the associations of fractalkine receptor (CX3CR1) V249I, T280M and CCR5-59029 A/G gene polymorphisms in chronic renal failure (CRF) subjects undergoing hemodialysis and to evaluate possible associations of these... more
We aimed to investigate the associations of fractalkine receptor (CX3CR1) V249I, T280M and CCR5-59029 A/G gene polymorphisms in chronic renal failure (CRF) subjects undergoing hemodialysis and to evaluate possible associations of these polymorphisms with hypertension (HT), diabetes mellitus (DM) and atherosclerosis (AS). A total of 225 CRF subjects undergoing hemodialysis and 201 healthy controls were enrolled in the study. CRF subjects were divided into three major subgroups according to comorbidities including HT (n = 127), DM (n = 65) and AS (n = 33). Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism method. The II genotype and I allele frequencies of CX3CR1 V249I polymorphism were found significantly more frequent in CRF subjects, CRF subjects with DM and CRF subjects with AS compared with controls (p &amp;amp;amp;amp;lt; 0.05 for all comparisons). G allele frequency of CCR5 polymorphism was found significantly more prevalent in CRF subjects with DM than that of controls. Further, GG genotype and G allele frequencies of CCR5 polymorphism were significantly more prevalent in CRF subjects with AS compared with controls (p &amp;amp;amp;amp;lt; 0.05). We also explored these polymorphisms among CRF subjects with and without following comorbidities: HT, DM, AS. We found significant association between CRF subjects with HT and without HT in terms of genotype and allele frequencies of V249I polymorphism (p &amp;amp;amp;amp;lt; 0.05). CX3CR1 T280M polymorphism was not found significantly different in none of the comparisons. These data demonstrate possible associations between CX3CR1 V249I and CCR5-59029 A/G polymorphisms and/or HT, DM and AS in CRF subjects.
Research Interests:
Fabry disease (FD) is a progressive, X-linked inherited disorder of glycosphingolipid metabolism due to deficient or absent lysosomal alpha-galactosidase A (AGALA) activity. FD and familial Mediterranean fever (FMF) have typical clinical... more
Fabry disease (FD) is a progressive, X-linked inherited disorder of glycosphingolipid metabolism due to deficient or absent lysosomal alpha-galactosidase A (AGALA) activity. FD and familial Mediterranean fever (FMF) have typical clinical similarities, and both diseases may progress to end-stage renal diseases. In this study, we aimed to determine the prevalence of FD in patients with FMF from Central Anatolia of Turkey. The study group consisted of 177 FMF patients, followed up by the Adult and Pediatric Nephrology Clinic of Cumhuriyet University Hospital. Screening for AGALA activity was performed by the dry blood spot method. Mutation analysis for GLA gene was carried out for patients having an AGALA enzyme activity value lower than the normal reference value. Low AGALA activity was detected in 23 (13 %) patients. Heterozygous GLA gene mutation c.[937G&amp;amp;amp;amp;amp;amp;gt;T] p.[D313Y] was detected in one female patient (0.56 %). The patient was a 53-year-old female with proteinuria and who had undergone left nephrectomy; her glomerular filtration rate (GFR) by scintigraphy was found to be 70 ml/min. She had M694V mutation and no clinical manifestation of FD. In our study, the prevalence rate of FD was found as 0.56 % in FMF patients. The similarities between the symptoms of FMF and FD might lead to a diagnostic dilemma in physicians at countries where FMF is observed frequently. Although the prevalence of FD is rare, physicians should keep in mind that FD has an ambiguous symptomology pattern of FMF.