David Caisa

Los factores de elección de marca forman parte del análisis del comportamiento del consumidor con relación a los efectos generados por las empresas al momento de realizar una compra. Por tal razón, se estudió el modelo Customer Brand Based Equity (CBBE) con el propósito de enunciar la dimensión más significativa dentro del análisis de factores de elección de marca de sodas. El estudio posee un enfoque cuantitativo y cualitativo debido a que se analizaron los efectos generados a partir del estudio de cincuenta artículos indexados. El alcance de la investigación es correlacional, debido a que se estudió la relación de las variables de estudio y el modelo. El resultado principal reveló que el modelo es asociable a las variables de estudio, puesto que, se obtuvo un P valor de 0.0217. Sin embargo, se obtuvo un grado de inconformidad con la heterogeneidad IC=0.982. Como conclusión principal, se reveló que el modelo CBBE de Aaker (1996), es adaptable a las variables de estudio, no obstante...

Schwannomatosis is characterized by multiple peripheral and cranial nerve schwannomas that occur in the absence of bilateral 8th cranial nerve schwannomas. The latter is the main diagnostic criterion of neurofibromatosis type 2 (NF2), which is a related but distinct disorder. The genetic factors underlying the differences between schwannomatosis and NF2 are poorly understood, although available evidence implicates chromosome 22 as the primary location of the gene(s) of interest. To investigate this, we comprehensively profiled the DNA copy number in samples from sporadic and familial schwannomatosis, NF2, and a large cohort of normal controls. Using a tiling-path chromosome 22 genomic array, we identified two candidate regions of copy number variation, which were further characterized by a PCR-based array with higher resolution. The latter approach allows the detection of minute alterations in total genomic DNA, with as little as 1.5 kb per measurement point of nonredundant sequence on the array. In DNA derived from peripheral blood from a schwannomatosis patient and a sporadic schwannoma sample, we detected rearrangements of the immunoglobulin lambda (IGL) locus, which is unlikely to be due to a B-cell specific somatic recombination of IGL. Analysis of normal controls indicated that these IGL rearrangements were restricted to schwannomatosis/schwannoma samples. In the second candidate region spanning GSTT1 and CABIN1 genes, we observed a frequent copy number polymorphism at the GSTT1 locus. We further describe missense mutations in the CABIN1 gene that are specific to samples from schwannomatosis and NF2 and make this gene a plausible candidate for contributing to the pathogenesis of these disorders. Hum Mutat 26(6), 540–549, 2005. © 2005 Wiley-Liss, Inc.