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Research Interests: Gastroenterology, Biomarkers, Medicine, Linear models, Multivariate Analysis, and 15 moreHumans, Internal Medicine, Hypertension, Female, Male, Aged, Middle Aged, C reactive protein, Monocytes, High Density Lipoprotein, Coronary Artery Disease, Asymptomatic, Abdominal Aortic Aneurysm, Monocyte, and Aorta Abdominal
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Aim: This study aims to assess the predictive role of the preprocedural circulating monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) on the occurrence of stent restenosis (SR) in patients with stable and unstable angina... more
Aim: This study aims to assess the predictive role of the preprocedural circulating monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) on the occurrence of stent restenosis (SR) in patients with stable and unstable angina pectoris undergoing successful bare-metal stenting (BMS). Patients & methods: Between February 2008 and June 2014, a total of 831 patients with stable and unstable angina pectoris who underwent successful BMS were retrospectively analyzed. Demographic and clinical characteristics of the patients were recorded. Left ventricular ejection fraction and laboratory data were also noted. Results: In the receiver operating characteristics curve analysis, MHR >14 had 71% sensitivity and 69% specificity in predicting SR. Conclusion: Our study results show that preprocedural MHR is an independent predictor of SR in this patient population.
Research Interests: Cardiology, Medicine, Stents, Humans, Internal Medicine, and 15 moreFemale, Male, ROC Curve, Aged, Middle Aged, Coronary Angiography, Monocytes, Odds ratio, Retrospective Studies, Ejection Fraction, Sensitivity and Specificity, Receiver Operating Characteristic, Area Under Curve, Unstable Angina, and Restenosis
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Research Interests: Medicine and Gynecology
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Research Interests: Treatment Outcome, Medicine, Heart Failure, Humans, Internal Medicine, and 13 moreFemale, Male, Mace, Recurrence, Aged, Percutaneous Coronary Intervention, Myocardial Infarction, Time Factors, Retrospective Studies, Age Factors, Hospital Mortality, Cardiogenic shock, and Cardiovascular medicine and haematology
Research Interests: Risk assessment, Medicine, Humans, Internal Medicine, Hospitalization, and 15 moreFemale, Male, Incidence, Clinical Sciences, Middle Aged, Infective Endocarditis, Reproducibility of Results, Risk Assessment, Hospital Mortality, Sensitivity and Specificity, Embolism, Statistics as Topic, Mean platelet volume, Adverse effect, and Staphylococcal infections
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Research Interests: Risk assessment, Medicine, Humans, Internal Medicine, Hospitalization, and 15 moreFemale, Male, Incidence, Clinical Sciences, Middle Aged, Infective Endocarditis, Reproducibility of Results, Risk Assessment, Hospital Mortality, Sensitivity and Specificity, Embolism, Statistics as Topic, Mean platelet volume, Adverse effect, and Staphylococcal infections
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In patients with severe aortic stenosis, the data about the incidence of acquired thrombocytopenia according to the use of balloon-expandable or self-expandable valves are limited. We investigated the relationship between the... more
In patients with severe aortic stenosis, the data about the incidence of acquired thrombocytopenia according to the use of balloon-expandable or self-expandable valves are limited. We investigated the relationship between the post-transcatheter aortic valve replacement (TAVR) thrombocytopenia and the balloon-expandable or self-expandable valves. A total of 127 consecutive patients who underwent TAVR were retrospectively analyzed. Among the study population, 61 (48%) patients underwent TAVR with the balloon-expandable valve and the 66 (52%) patients with the self-expandable valve. Procedural success did not differ between the groups ( P = .575). The access site complications and in-hospital mortality were the same across the groups ( P = .225 and P = .466). However, paravalvular (PV) leaks were significantly higher in the self-expandable valve group ( P = .007). Among all, 65 patients experienced thrombocytopenia, which was more frequent in the self-expandable valve group (63.6 vs 37...
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Aim: This study aims to assess the predictive role of the preprocedural circulating monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) on the occurrence of stent restenosis (SR) in patients with stable and unstable angina... more
Aim: This study aims to assess the predictive role of the preprocedural circulating monocyte to high-density lipoprotein (HDL) cholesterol ratio (MHR) on the occurrence of stent restenosis (SR) in patients with stable and unstable angina pectoris undergoing successful bare-metal stenting (BMS). Patients & methods: Between February 2008 and June 2014, a total of 831 patients with stable and unstable angina pectoris who underwent successful BMS were retrospectively analyzed. Demographic and clinical characteristics of the patients were recorded. Left ventricular ejection fraction and laboratory data were also noted. Results: In the receiver operating characteristics curve analysis, MHR >14 had 71% sensitivity and 69% specificity in predicting SR. Conclusion: Our study results show that preprocedural MHR is an independent predictor of SR in this patient population.
Research Interests: Cardiology, Medicine, Stents, Humans, Internal Medicine, and 15 moreFemale, Male, ROC Curve, Aged, Middle Aged, Coronary Angiography, Monocytes, Odds ratio, Retrospective Studies, Ejection Fraction, Sensitivity and Specificity, Receiver Operating Characteristic, Area Under Curve, Unstable Angina, and Restenosis
Aim: To determine the association of monocyte count-to-high-density lipoprotein (HDL)-cholesterol ratio, a recently emerged inflammatory marker, with abdominal aortic aneurysm (AAA) size. Patients & methods: A total of 120 asymptomatic... more
Aim: To determine the association of monocyte count-to-high-density lipoprotein (HDL)-cholesterol ratio, a recently emerged inflammatory marker, with abdominal aortic aneurysm (AAA) size. Patients & methods: A total of 120 asymptomatic AAA subjects (99 male, mean age: 67.1 ± 10.2 years) were enrolled into the study. All data were compared between patients with low and high admission monocyte/HDL ratio. Multivariate linear regression analysis was performed to study the relationship between different variables and AAA size. Results: Compared to patients with below-median monocyte/HDL ratio, aneurysm diameter was significantly higher in above-median monocyte/HDL ratio group (54.3 ± 10.6 mm vs 62.0 ± 12.4 mm, p < 0.001, respectively). Hypertension, coronary artery disease, monocyte/HDL ratio and C-reactive protein were independently associated with AAA diameter. Conclusion: Monocyte/HDL ratio is independently associated with AAA size.
Research Interests: Gastroenterology, Biomarkers, Medicine, Linear models, Multivariate Analysis, and 15 moreHumans, Internal Medicine, Hypertension, Female, Male, Aged, Middle Aged, C reactive protein, Monocytes, High Density Lipoprotein, Coronary Artery Disease, Asymptomatic, Abdominal Aortic Aneurysm, Monocyte, and Aorta Abdominal
Serum uric acid (UA) is independently associated with hypertension and blood pressure (BP) variability (BPV) is associated with cardiovascular events and mortality in hypertensive patients. The aim of the present study was to assess the... more
Serum uric acid (UA) is independently associated with hypertension and blood pressure (BP) variability (BPV) is associated with cardiovascular events and mortality in hypertensive patients. The aim of the present study was to assess the association of serum UA with BPV in 300 untreated essential hypertension patients (mean age 57.3±13.6 years). BPV was quantified as the standard deviation (SD) of the 24-hour, daytime, and nighttime mean values obtained by using ambulatory BP monitoring. In correlation analysis, log UA values were found to be positively correlated with 24-hour systolic BPV and nighttime systolic and diastolic BPV (Pearson coefficients of 0.246, 0.280, and 0.353, respectively; P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.001 for all). In multivariate analysis, log UA had an independent association with 24-hour systolic BPV and nighttime systolic and diastolic BPV. This study show for the first time that increased serum UA is independently associated with BPV in untreated essential hypertension patients.
Research Interests: Cardiology, Medicine, Humans, Internal Medicine, Hypertension, and 13 moreBlood Pressure, Circadian Rhythm, Female, Male, Clinical Sciences, Aged, Middle Aged, Uric Acid, Cross Sectional Studies, Ambulatory Blood Pressure, Diastole, Cardiovascular medicine and haematology, and Medical biochemistry and metabolomics
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Research Interests: Gastroenterology, Biomarkers, Medicine, Prospective studies, Humans, and 15 moreInternal Medicine, Female, Male, Patient Admission, Clinical Sciences, Aged, Middle Aged, C reactive protein, Adult, Prognosis, eNDOCARDITIS, Hospital Mortality, Proportional Hazards Models, Predictive value of tests, and Prospective Cohort Study
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ABSTRACT Fragmented QRS complex (fQRS) is associated with cardiovascular outcomes in various patient populations. Although there were clinical studies investigating the association of fQRS with arrhythmic events in patients with systolic... more
ABSTRACT Fragmented QRS complex (fQRS) is associated with cardiovascular outcomes in various patient populations. Although there were clinical studies investigating the association of fQRS with arrhythmic events in patients with systolic heart failure, the results were conflicting regarding the association of implantable cardioverter defibrillator (ICD) shocks and fQRS. In this study, we aimed to evaluate the association between the presence and extent of fQRS with appropriate ICD shocks and/or all-cause mortality.
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ABSTRACT Objectives: Epicardial fat tissue is a type of visceral adipose tissue that functions as a metabolically active endocrine organ. Most components of metabolic syndrome (MetS), especially visceral obesity, are associated with a... more
ABSTRACT Objectives: Epicardial fat tissue is a type of visceral adipose tissue that functions as a metabolically active endocrine organ. Most components of metabolic syndrome (MetS), especially visceral obesity, are associated with a low-grade systemic inflammatory state. In this study, we aimed to assess the relationship between echocardiographic epicardial fat thickness (EFT), MetS, the components of MetS, and high sensitivity C-reactive protein (hs-CRP) levels in patients with MetS. Study design: Forty-six patients (25 males, mean age 47.3±6.5 years) with the diagnosis of MetS (according to the Adult Treatment Panel III update criteria) but without clinical coronary artery disease, and 44 age and gender matched healthy volunteers (18 males, mean age 46.0±6.1 years) were included in the study. EFT, which was measured by transthoracic echocardiography, as well as clinical and biochemical parameters were compared between the two groups. Results: Waist circumference, total and LDL-cholesterol, fasting glucose, triglycerides, systolic and diastolic blood pressure levels, hs-CRP, and uric acid levels were significantly higher in patients with MetS. EFT was also significantly increased in patients with MetS (8.7±0.2 mm vs. 4.8±0.1 mm, p&lt;0.001). Multiple regression analysis determined that MetS itself (ß=0.929, p&lt;0.001) and hs-CRP (r=-0.181, p=0.007) are independent predictors of increased EFT. Conclusion: This study demonstrates that EFT is higher in patients with MetS, and that MetS and hsCRP are independent predictors of this increased EFT. Increased EFT, which is associated with low-grade systemic inflammation, may play a role in the pathogenesis of atherosclerosis in MetS patients.