Hasan Demirhan

This study was designed to compare the levels of dityrosine-containing protein cross-link products, also known as advanced oxidation protein products (AOPP); in patients with allergic rhinitis with those in healthy individuals considering the fact that AOPP has the potential to be a marker of oxidative stress specific to proteins in mammalian systems. This study was performed on 40 patients (18 males, 22 females; mean age 29 years; range 10 to 53 years) with allergic rhinitis admitted to our clinic between December 2008 and January 2009 and on 40 healthy volunteers (16 males, 24 females; mean age 31 years; range 13 to 48 years). Skin prick test was performed to establish a diagnosis of allergic rhinitis in patients with major symptoms and allergic sensitization was also supported with serum IgE levels. Blood samples were obtained and examined in all patients to determine AOPP. Serum AOPP levels were significantly higher in patients with allergic rhinitis (169.0+/-14.2 micromol/L) co...

The purpose of this study was to assess the patency of the internal jugular vein after functional neck dissection. Twenty-five patients (6 females, 19 males; mean age 53.9 years; range 30 to 71 years) who were operated on because of larynx, hypopharynx and intraoral cavity tumors in the Ear, Nose and Throat Clinic of Haseki Training and Research Hospital between January 2001 and March 2003 were included in the study. Internal jugular veins were evaluated after 42 functional neck dissections. By means of power duplex Doppler ultrasonography, the jugular blood flow, presence or absence of a thrombus, diameter of the vein, velocity of the blood flow were evaluated. In our study the internal jugular vein patency rate was found to be 95.2%, and thrombosis was detected only in two patients. Blood flow velocity in patients with thrombus was found to be significantly lower than that observed in patients without thrombus (p<0.05). It was observed that blood flow of the internal jugular ve...

Patients with asthma, allergic rhinitis, or atopic dermatitis experience increased oxidative stress. We conducted a prospective study to examine the levels of advanced oxidation protein products (AOPPs) as an indicator of oxidative stress in 97 patients with allergic rhinitis who were followed in our clinic during a 3.5-month period. Of these 97 patients, 51 were treated with subcutaneous immunotherapy (SCIT), and 46 did not receive any treatment until the study was concluded. In each patient, allergic rhinitis and allergic sensitization were documented by the history, the findings on clinical examination, and the results of blood and skin-prick tests. Blood samples from each patient were analyzed to determine AOPP levels. We found that the mean serum AOPP level was significantly higher in the SCIT group than in the non-SCIT group (258.55 vs. 163.83 µmol/L; p = 0.0015). We conclude that as a known indicator of protein oxidation, the serum AOPP level is a marker of increased oxidativ...

In the present experimental study, we sought to monitor distortion product otoacoustic emissions (DPOAEs) as an indicator of cochlear function, after sudden, total, and irreversible interruption of cochlear blood flow, to provide information on the time course of cochlear response to ischemia. Twenty rats with normal hearing function were included. Complete and abrupt ischemia was provided by decapitation. DPOAEs at 3-8 kHz frequencies were recorded at baseline and exactly every consecutive minute after decapitation, until emissions in all frequencies disappeared completely. Mean DPOAE values decreased significantly and progressively after decapitation for all frequencies. The mean duration of emissions was 8.20 ± 1.96 min (minimum 3 min, maximum 11 min). The longest durations of DPOAEs were observed with 4 and 5 kHz frequencies, and 3 and 6 kHz had the shortest durations. The outer hair cells exposed to acute ischemia seem to exhibit a rapid functional loss; thus, cautious handling...

To compare the efficacy and safety of radiofrequency and monopolar electrocautery tonsillectomy, regarding operation duration and tonsillectomy morbidity, including post-operative pain and haemorrhage and tonsillar fossa healing, in patients with recurrent chronic tonsillitis. A prospective, randomised, double-blind, controlled clinical study. Fifty patients aged over 10 years who required tonsillectomy were randomly assigned to have one tonsil removed by radiofrequency and the other by monopolar electrocautery. Operation duration, post-operative haemorrhage, post-operative pain and tonsillar fossa wound healing were compared. The mean +/- standard deviation of the operation duration required for the radiofrequency method was significantly longer than that for monopolar electrocautery: 8.1 +/- 1.6 minutes vs 7.3 +/- 1.5 minutes, respectively (p = 0.034). Post-operative haemorrhage was observed in only three patients (13.6 per cent). Inter-group analysis showed no significant differences in post-operative pain scores for the radiofrequency vs monopolar electrocautery methods (3.7 +/- 1.6 vs 3.3 +/- 1.4, respectively; p < 0.126). Inter-group analysis showed that tonsillar fossa wound healing scores evaluated on the fifth, 10th and 14th post-operative days were significantly higher in the radiofrequency group compared with the monopolar electrocautery group (p < 0.001). The present study results indicated that monopolar electrocautery tonsillectomy was superior to radiofrequency tonsillectomy in terms of post-operative tonsillar fossa wound healing; however, both techniques were comparable in terms of post-operative pain.

To evaluate the role of distortion product otoacoustic emissions (DPOAE) results in children with middle-ear effusion before and after ventilation tube insertion. The study was conducted between the September 2007 and May 2008 at the Otolaryngology Clinic diagnosed with middle-ear effusion. A prospective study was carried out 30 patient (18 males, 12 females; mean age 8.6 years; range 6 to 15 years) and a total of 41 ears with middle-ear effusion. A total of 30 ears of 15 volunteers healthy control group (8 males, 7 females; mean age 7.8 years; range 5 to 15) included in the study. All children listed for appropriate surgery had a pre- and postoperative (four week after) tympanometry, pure tone audiometry and DPOAE recorded. A comparison was made between control group DPOAE value and pre- and postoperative DPOAE value of patient. Preoperatively, 41 ears had an abnormal tympanometry of which 80% had absent DPOAE. After four week all postoperative patients with surgery had 92.6% a normal DPOAE. Control group of 29/30 ears had a normal (96.7%) DPOAE. Patients with otitis media with effusion measured preoperative DPOAE, postoperative after one month all patients with grommets had a more DPOAE value comparison with preoperative, but less for control group.