Aim. We investigated the literature of randomised placebo-controlled trials to find out if transcutaneous electrical nerve stimulation (TENS) or acupuncture-like transcutaneous electrical nerve stimulation (ALTENS) can reduce analgesic... more
Aim. We investigated the literature of randomised placebo-controlled trials to find out if transcutaneous electrical nerve stimulation (TENS) or acupuncture-like transcutaneous electrical nerve stimulation (ALTENS) can reduce analgesic consumption after surgery.Results. Subgroup analysis for adequate treatment (pulse frequency: 1–8 Hz [ALTENS] or 25–150 Hz [TENS], current intensity: “strong, definite, subnoxious, maximal tolerable” or above 15 mA, and electrode placement in the incision area) were performed. Twenty-one randomised, placebo-controlled trials with a total of 1350 patients were identified. For all trials, the mean reduction in analgesic consumption after TENS/ALTENS was 26.5% (range −6 to +51%) better than placebo. Eleven of the trials compromising 964 patients, had reports which stated that a strong, subnoxious electrical stimulation with adequate frequency was administered. They reported a mean weighted reduction in analgesic consumption of 35.5% (range 14–51%) better than placebo. In nine trials without explicit confirmation of sufficient current intensity and adequate frequency, the mean weighted analgesic consumption was 4.1% (range −10 to +29%) in favour of active treatment. The difference in analgesic consumption was significantly (p=0.0002) in favour of adequate stimulation. The median frequencies used in trials with optimal treatment was 85 Hz for TENS and 2 Hz in the only trial that investigated ALTENS.Conclusion. TENS, administered with a strong, subnoxious intensity at an adequate frequency in the wound area, can significantly reduce analgesic consumption for postoperative pain.
The objective of this study was to evaluate the effect of laser irradiation on dog bone marrow stem cells. Low doses of low-level red laser positively affect the viability of mesenchymal stem cells, and also increase proliferation.... more
The objective of this study was to evaluate the effect of laser irradiation on dog bone marrow stem cells. Low doses of low-level red laser positively affect the viability of mesenchymal stem cells, and also increase proliferation. Low-level laser (wavelength, 660 nm; power output, 50 mW), was applied to dog bone marrow stem cell cultures (DBMSC). The energy densities delivered varied from 1 to 12J/cm(2). The effect of the laser irradiation was evaluated on cell proliferation measured with the MTT colorimetric test, cell cycle phase, and on lipidic peroxidation (free radical production). The results indicate that laser irradiation to DBMSC did not change the morphology of the cells, but significantly increased their viability and the number of cells at the G2/M phase with 6, 10, and 12 J/cm(2). On the other hand, malonaldehyde production was significantly enhanced with 8 J/cm(2). The parameters used to irradiate DBMSC increased significantly proliferation without producing high levels of reactive oxygen species (ROS).
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... Jan M Bjordal 1. amanuensis Anne Elisabeth Ljungren professor Atle Klovning 1. amanuensis; alla vidInstitutt for Samfunnsmedisinske fag,Universitetet i Bergen Lars Slørdal professor, Institutt for ... 7. Reikvam Å, Hexeberg S, Kvien... more
... Jan M Bjordal 1. amanuensis Anne Elisabeth Ljungren professor Atle Klovning 1. amanuensis; alla vidInstitutt for Samfunnsmedisinske fag,Universitetet i Bergen Lars Slørdal professor, Institutt for ... 7. Reikvam Å, Hexeberg S, Kvien TK, Slørdal, L, Aabakken L, Engebretsen L, et al ...
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Vi stiller oss bak Peter Storm-Henningsens anbefaling av Vlad og medarbeideres analyse av de placebokontrollerte, randomiserte kliniske forsøkene med glukosamin ved artrose (1). Forfatterne viser at det er forskjeller mellom resultatene... more
Vi stiller oss bak Peter Storm-Henningsens anbefaling av Vlad og medarbeideres analyse av de placebokontrollerte, randomiserte kliniske forsøkene med glukosamin ved artrose (1). Forfatterne viser at det er forskjeller mellom resultatene fra dem med økonomiske interessekonflikter i glukosaminfeltet (som gjennomgående finner at midlet har effekt) og fra dem uten slike interessekonflikter (som ikke påviser klinisk relevante effekter). De industrifinansierte studiene oppviser en heterogenitet som ikke kan forklares ut fra tilfeldighetenes spill - her er det altså «ugler i mosen». At vi ikke refererte til studien av Vlad og medarbeidere (1), skyldes det enkle faktum at vi sendte inn vårt manus til kronikken (2) i februar 2007, mens artikkelen til Vlad og medarbeidere (1) ble publisert i juli 2007. Kommentarene fra Reginster (3) og fra Altman og medarbeidere (4) tilfører lite nytt. Påstanden om at vi avviser studier «alene på baggrund af mulige interessekonflikter» er direkte gal. I vår k...
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In a recent overview encompassing systematic reviews and randomized trials of pharmacotherapy in low back pain (LBP), the authors concluded that there is good evidence that acetaminophen, NSAID and muscle relaxants provide moderate pain... more
In a recent overview encompassing systematic reviews and randomized trials of pharmacotherapy in low back pain (LBP), the authors concluded that there is good evidence that acetaminophen, NSAID and muscle relaxants provide moderate pain relief in acute LBP (1). In another clinical guideline article in the same issue of the Annals (2), the recommended indications for acetaminophen and NSAIDs are extended to include chronic LBP, whereas tramadol, opiods, and benzodiazepines are recommended both in acute and chronic LBP despite the lack of “good” or even “fair” evidence. The methodology used by the authors to review the literature may be flawed in the sense that it merely reiterates what other reviewers have published previously. The current overview does not address crucial differences in focus and protocols of the included reviews, and fails to adequately assess the randomized controlled trials which are the primary sources for information. The criteria list which was used does not i...
he overviews of non-pharmacological(1) and pharmacological treatments(2) form the basis for the treatment recommendations 6 and 7 in this guideline (3) for low back pain management. We have previously pointed out in rapid responses to the... more
he overviews of non-pharmacological(1) and pharmacological treatments(2) form the basis for the treatment recommendations 6 and 7 in this guideline (3) for low back pain management. We have previously pointed out in rapid responses to the journal website that the overview method is methodologically inferior to systematic reviews, and that the real power of the scientific evidence is not transparently available for critical appraisal in overviews. Overviews also tend to be biased in favour of those interventions where systematic reviews -however poor- have been included in the overview. In this guideline (3), clinicians are strongly advised to (always) “consider the use of medications” and “first- line options are acetaminophen or non-steroidal anti-inflammatory drugs”. Non-pharmacological treatments are given “weak recommendations”, but only for “patients who do not improve”. Superficial heat packs, low level laser therapy (LLLT) and transcutaneous electrical nerve stimulation (TENS...
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... 2006 Aug;24(4):533-4; author reply 534. Ineffective dose and lack of laser output testing in laser shoulder and neck studies. Bjordal JM, Baxter GD. Comment on Photomed Laser Surg. 2005 Oct;23(5):459-64. PMID: 16995282 [PubMed -... more
... 2006 Aug;24(4):533-4; author reply 534. Ineffective dose and lack of laser output testing in laser shoulder and neck studies. Bjordal JM, Baxter GD. Comment on Photomed Laser Surg. 2005 Oct;23(5):459-64. PMID: 16995282 [PubMed - indexed for MEDLINE]. ...
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Chronic obstructive pulmonary disease (COPD) can lead to severe disability as the disease advances. The 6-minute walk test (6MWT) is commonly used to measure functional capacity in COPD patients and has three potential outcomes; walking... more
Chronic obstructive pulmonary disease (COPD) can lead to severe disability as the disease advances. The 6-minute walk test (6MWT) is commonly used to measure functional capacity in COPD patients and has three potential outcomes; walking distance, oxygen desaturation, and self-perceived dyspnea assessed by the Borg scale, all reflecting different aspects of COPD. The aim of this study was to identify predictors of all 3 outcomes of 6MWT in patients with COPD. 370 COPD patients, aged 40-75 yrs, were included from the first phase of the Bergen COPD cohort study. They were examined with spirometry, bioelectrical impedance measurements, 6MWT, Center for Epidemiologic Studies of Depression (CES-D) Scale, Medical Research Council (MRC) dyspnea scale, Charlson index for co-morbidities, self-reported physical activity questionnaire, plasma levels of C-reactive protein (CRP) and arterial blood gases. Significant predictors in the multivariate analyses were sex, age, FEV(1) in % predicted, symptoms of dyspnea (MRC), co-morbidities (Charlson Index) and self-reported physical activity for walking distance, FEV(1) in % predicted and PaO(2) for oxygen desaturation, and body composition, smoking and co-morbidities for self-perceived dyspnea assessed by the Borg scale. Several COPD characteristics have predictive value for the 6MWT, and some COPD characteristics are more strongly related to specific 6MWT outcomes than others.
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Objective: Concomitant use of multiple therapies is common in musculoskeletal and airway disorders. Low level laser therapy (LLLT) is considered a promising therapy in arthritis, tendinopathies and rhinitis. We designed two animal studies... more
Objective: Concomitant use of multiple therapies is common in musculoskeletal and airway disorders. Low level laser therapy (LLLT) is considered a promising therapy in arthritis, tendinopathies and rhinitis. We designed two animal studies to assess if the expected anti-inflammatory effect LLLT could be affected by resection of the adrenal gland or concomitant use of the cortisol antagonist mifepristone. Methods: Two studies were performed, with 40 male Wistar rats and with 40 Balb C male mice respectively.. In both studies, four groups received carrageenan and one control group received saline. At 1, 2, and 3 hours after injections, LLLT irradiation was performed with a dose of 7.5 J/cm2. In the rat study, two of the carrageenan groups had the adrenal gland dissected. In the mice study, two of the carrageenan-injected groups were in addition pre-treated with orally administered mifepristone. Results: In the rat paw study, LLLT reduced edema significantly compared to the carrageenan only group (1.5 vs 0.9 ml, p< 0.05), but LLLT failed to inhibit edema formation in the group which had the adrenal gland resected. In carrageenan-induced pleurisy, LLLT significantly reduced the number of leukocyte cells ( p<0.0001, Mean 34.5 [95%CI: 32.8 - 36.2] versus 87.7 [95%CI: 81.0 - 94.4]), and that the effect of LLLT could be totally blocked by adding the cortisol antagonist mifepristone ( p<0.0001, Mean 34.5 [95%CI: 32.1 - 36.9] versus 82.9 [95%CI: 70.5 - 95.3]). Conclusion: Steroid therapy should not be used concomitantly with LLLT, as the anti-inflammatory effect of LLLT is lost if cortisol receptors are downregulated.
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The purpose of the study is to compare the effect in healthy young adults of two resistance training protocols, six-repetition maximum (RM) versus 12RM on maximum strength (1RM). A single-blind, randomized controlled trial was used in the... more
The purpose of the study is to compare the effect in healthy young adults of two resistance training protocols, six-repetition maximum (RM) versus 12RM on maximum strength (1RM). A single-blind, randomized controlled trial was used in the study. Sixty-two healthy physical therapy students, with age (mean [+standard deviation]) 23 (+2.6) years, weight 67.4 (+11.7) kg and height 171.7 (+8.4) cm, of both genders who were recreationally active, but not training systematically, volunteered to participate in the study. They were randomized into two groups (group 1: 24 women and 8 men; group 2: 23 women and 7 men) by a block randomization procedure that ensured equal gender distribution. Sealed envelopes were used to conceal allocation to groups. Group 1 did three sets of 6RM of each exercise, and group 2 did three sets of 12RM. Both groups performed the exercises twice per week for 8 weeks with 3 minutes rest between sets and exercises. Primary outcomes were maximum strength defined as one-repetition maximum squat (1RMSq) for lower-body strength and bench press (1RMBp) for upper-body strength. Secondary outcomes were body weight and Uro Kaleva Kekkonen (UKK) Fitness Index. Both groups increased strength significantly (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001) in 1RMSq (6RM 13.6%, 12RM 13.5%) and 1RMBp (6RM 9.2%, 12RM 8.4%). There was no significant difference in the change between the two groups, no change in body weight and only a small increase in UKK Fitness Index. Both 6RM and 12RM training protocols improve maximum strength in recreationally active healthy young adults, with no significant difference between the protocols.
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... Jan Magnus Bjordal 1 , Corresponding Author Contact Information , E-mail The Corresponding Author , Jan Hendrik Demmink 2 and Anne Elisabeth Ljunggren 3. Received 8 January 2002; accepted 16 January 2003. Available online 1 October... more
... Jan Magnus Bjordal 1 , Corresponding Author Contact Information , E-mail The Corresponding Author , Jan Hendrik Demmink 2 and Anne Elisabeth Ljunggren 3. Received 8 January 2002; accepted 16 January 2003. Available online 1 October 2005. Summary. Objective. ...
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We designed an animal pleurisy study to assess if the anti-inflammatory effect of photoradiation could be affected by concomitant use of the cortisol antagonist mifepristone. Although interactions between photoradiation and... more
We designed an animal pleurisy study to assess if the anti-inflammatory effect of photoradiation could be affected by concomitant use of the cortisol antagonist mifepristone. Although interactions between photoradiation and pharmacological agents are largely unknown, parallel use of steroids and photoradiation is common in the treatment of inflammatory disorders such as arthritis and tendinitis. Forty BALB/c male mice were randomly divided in five groups. Inflammation was induced by carrageenan administered by intrathoracic injections. Four groups received carrageenan, and one control group received injections of sterile saline solution. At 1, 2, and 3 h after injections, photoradiation irradiation was performed with a dose of 7.5 J/cm(2). Two of the carrageenan-injected groups were pre-treated with orally administered mifepristone. Total leukocyte cell counts revealed that in carrageenan-induced pleurisy, photoradiation significantly reduced the number of leukocyte cells (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001, mean 34.5 [95% CI: 32.8-36.2] versus 87.7 [95% CI: 81.0-94.4]), and that the effect of photoradiation could be totally blocked by adding the cortisol antagonist mifepristone (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001, mean 34.5 [95% CI: 32.1-36.9] versus 82.9 [95%CI: 70.5-95.3]). The steroid receptor antagonist mifepristone significantly inhibited the anti-inflammatory effect of photoradiation. Commonly used glucocorticoids are also known to down-regulate steroid receptors, and further clinical studies are necessary to elucidate how this interaction may decrease the effect size of photoradiation over time. For this reason, we also suggest that, until further clinical data can be provided, clinical photoradiation trials should exclude patients who have received steroid therapy within 6 months before recruitment.
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The objective of this study was to investigate whether low level laser therapy (LLLT) could reduce bronchial hyper-responsiveness (BHR) induced by tumour necrosis factor-alpha (TNF-alpha) modulating the metabolism of inositol phosphate... more
The objective of this study was to investigate whether low level laser therapy (LLLT) could reduce bronchial hyper-responsiveness (BHR) induced by tumour necrosis factor-alpha (TNF-alpha) modulating the metabolism of inositol phosphate (IP) in bronchial smooth muscle cells (BSMCs). The study was on 28 Wistar rats, randomly divided into four groups. Irradiation (1.3 J/cm(2)) was administered 5 min and 4 h after bronchial smooth muscle (BSM) had been suspended in TNF-alpha baths, and the contractile response-induced calcium ion (Ca(2+)) sensitization was measured. The BSMCs were isolated, and the IP accumulation was measured before and after TNF-alpha immersion in the groups that had been irradiated or not irradiated. BSM segments significantly increased contraction 24 h after TNF-alpha immersion when exposed to carbachol (CCh) as Ca(2+), but it was significantly reduced by 64% and 30%, respectively, after laser treatment. The increase in IP accumulation induced by CCh after TNF-alpha immersion was reduced in the BSMCs by LLLT. The dose of 2.6 J/cm(2) reduced BHR and IP accumulation in the rats&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; inflammatory BSMCs.
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It is claimed that transcutaneous electrical nerve stimulation (TENS) operates via a segmental mechanism by reducing ongoing transmission and sensitization of nociceptive dorsal horn neurons. Hence, TENS electrodes are usually placed at... more
It is claimed that transcutaneous electrical nerve stimulation (TENS) operates via a segmental mechanism by reducing ongoing transmission and sensitization of nociceptive dorsal horn neurons. Hence, TENS electrodes are usually placed at the site of pain. This study compared TENS administered at the site of experimentally induced ischemic pain (ipsilateral forearm) with TENS administered at a location not related to pain (contralateral lower leg). Ten healthy, pain free volunteers took part in a cross-over study during which ischemic pain was induced in the nondominant arm using a modified version of submaximal effort tourniquet technique. Pain intensity was taken at 1-minute interval/s for 5 minutes while receiving TENS either at the ipsilateral arm or contralateral leg. There were no statistically significant differences in pain intensity or McGill Pain Questionnaire ratings between TENS given at the arm compared with the leg. Taken at face value, the findings suggest that TENS effects were nonspecific and that electrode location does not affect outcome. However, this study should be seen as a call for further research rather than a definitive conclusion.
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... 140 JM BJORDAL M.FL. ... I en systematisk analyse av rando-miserte, dobbeltblindete, placebokontrollerte studier av glukosamin påviste Vlad og medarbeidere (24) at de uavhengige studiene var ensartede i sine resultater, mens... more
... 140 JM BJORDAL M.FL. ... I en systematisk analyse av rando-miserte, dobbeltblindete, placebokontrollerte studier av glukosamin påviste Vlad og medarbeidere (24) at de uavhengige studiene var ensartede i sine resultater, mens industristudiene altså de som fant effekt av ...
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Research Interests: Mechanical Engineering, Biomedical Engineering, Physical Activity, Tendon and Ligament injuries, Treatment Outcome, and 13 moreHumans, RECREATION, Chronic Disease, Female, Male, American, Low Level Laser Therapy, Tidal power density, Adult, Randomized Controlled Trial, Achilles tendon, Study design, and Laser Therapy
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The aim of this study was to test if a conclusion in a systematic review of low-level laser therapy (LLLT) for osteoarthritis from the Cochrane Library was valid and robust. Health policy decisions often rely on conclusions from the... more
The aim of this study was to test if a conclusion in a systematic review of low-level laser therapy (LLLT) for osteoarthritis from the Cochrane Library was valid and robust. Health policy decisions often rely on conclusions from the Cochrane Database of Systematic Reviews for approval of new therapies, although their validity for controversial non-pharmacological treatment has been questioned. Validity was tested against a nine-item checklist for systematic reviews. Review selections were analyzed for possible discrepancies between trial and review reports, and omissions of relevant trials and data. Alternative data from discrepancies and omissions were then imputed in a sensitivity analysis, to test if review conclusions were robust. Only clinicians who had performed LLLT trials with negative results were invited into the review group. Review quality was sound in areas of literature search and methodological assessments, and some of the limitations were mentioned. The statistical a...
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Some conclusions from the Cochrane Database of Systematic Reviews (CDSR) seem volatile in areas of controversy and have recently changed conclusions. With this perspective in mind we decided to test the validity and sensitivity of... more
Some conclusions from the Cochrane Database of Systematic Reviews (CDSR) seem volatile in areas of controversy and have recently changed conclusions. With this perspective in mind we decided to test the validity and sensitivity of negative conclusions in a systematic review of low-level laser therapy (LLLT) for osteoarthritis (OA) from the Cochrane Library was valid and robust. None as this was a systematic review of literature. Validity was tested against a 9-item checklist for systematic reviews. Review selections were analyzed for possible discrepancies between trial and review reports and omissions of relevant trials and data. Data from discrepancies and omissions were then entered into sensitivity and subgroup analyses. Continuous and dichotomous data for pain Patients with osteoarthritis. LLLT. Only clinicians who had performed LLLT trials, and had negative results were invited into the review group. The review was oblivious to findings published after 1993 about physiologic m...
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Physiotherapists practicing at clinical placement sites assigned the role as clinical instructors (CIs), are responsible for supervising physiotherapy students. For CIs to role model evidence-based practice (EBP) they need EBP competence.... more
Physiotherapists practicing at clinical placement sites assigned the role as clinical instructors (CIs), are responsible for supervising physiotherapy students. For CIs to role model evidence-based practice (EBP) they need EBP competence. The aim of this study was to assess the short and long term impact of a six-month multifaceted and clinically integrated training program in EBP on the knowledge, skills, beliefs and behaviour of CIs supervising physiotherapy students. We invited 37 CIs to participate in this non-randomized controlled study. Three self-administered questionnaires were used pre- and post-intervention, and at six-month follow-up: 1) The Adapted Fresno test (AFT), 2) the EBP Belief Scale and 3) the EBP Implementation Scale. The analysis approach was linear regression modeling using Generalized Estimating Equations. In total, 29 CIs agreed to participate in the study: 14 were invited to participate in the intervention group and 15 were invited to participate in the con...
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Low-level laser therapy (LLLT) is proposed as a treatment for tendinopathies. This is the first systematic review focusing solely on LLLT treatment effects in shoulder tendinopathy. A systematic review with meta-analysis and primary... more
Low-level laser therapy (LLLT) is proposed as a treatment for tendinopathies. This is the first systematic review focusing solely on LLLT treatment effects in shoulder tendinopathy. A systematic review with meta-analysis and primary outcome measures pain relief on 100-mm visual analogue scale (VAS) and relative risk for global improvement. Two independent assessors rated the included studies according to the PEDro scale. Intervention quality assessments were performed of LLLT dosage and treatment procedures according to World Association for Laser Therapy guidelines. The included trials were sub-grouped by intervention quality and use of other physiotherapy interventions. Seventeen randomized controlled trials (RCTs) met the inclusion criteria, and 13 RCTs were of high and 4 RCTs of moderate methodological quality. Significant and clinically important pain relief was found with weighted mean differences (WMD) over placebo, for LLLT as monotherapy at 20.41 mm (95% CI: 12.38 to 28.44)...
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ABSTRACT Title A systematic review of the literature of the effects of laser irradiation on peripheral mammalian nerves: implications for the analgesic effects of low-level laser therapy. Introduction Early studies of the effects of laser... more
ABSTRACT Title A systematic review of the literature of the effects of laser irradiation on peripheral mammalian nerves: implications for the analgesic effects of low-level laser therapy. Introduction Early studies of the effects of laser irradiation (LI) on peripheral nerves used an injury model to study stimulation of repair processes. The focus on stimulation was consistent with research in other domains of tissue repair where inhibition was seen as an unwanted response. In parallel, many authors described laser-induced neural inhibition, in particular of nociceptor activity, which led to the hypothesis that neural inhibition was central to laser-induced analgesia. Aim We sought to systematically evaluate the effects of LI in peripheral mammalian nerve models and to develop hypotheses for mechanisms of laser-induced pain modulation based on the review findings. Methods We searched computerized databases using key words for studies of LI of any wavelength to peripheral mammalian nerves. We excluded studies of non-mammalian nerves, experimentally injured nerves, studies in which LI was used as a noxious stimulus and studies without a control. Results We identified 41 studies suitable for evaluation, of pre and post-laser irradiation effects within nerves or neurons induced by visible and infrared wavelengths of LI in i) electrical activity; ii) functional activity and iii) morphology. Visible and infrared wavelengths caused inhibitory effects on electrical and functional neural activities. Morphological changes were seen with infrared LI. Specific anti-nociceptor and pain modulating effects were seen predominantly with infrared wavelengths. Conclusion Inhibition of neural activity is seen in many, but not all, studies of LI of peripheral nerves. Specificity for inhibitory effects increases when small diameter A and C fibres are targeted. As these fibres mediate pain perception, a mechanism by which LI reduces clinical pain, both acutely and in the long term, by direct inhibition of nociceptors, is proposed. No Yes
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Page 1. Current Rheumatology Reviews, 2007, 3, 147-154 147 1573-3971/07 $50.00+.00 © 2007 Bentham Science Publishers Ltd. Low Level Laser Therapy [LLLT] in Inflammatory and Rheumatic Dis-eases: A Review of Therapeutic Mechanisms ...
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The objective of this work was to investigate the anti-inflammatory effects of low-level laser therapy, applied at different wavelengths (660 and 684 nm), on cytokine mRNA expression after carrageenan-induced acute inflammation in rat... more
The objective of this work was to investigate the anti-inflammatory effects of low-level laser therapy, applied at different wavelengths (660 and 684 nm), on cytokine mRNA expression after carrageenan-induced acute inflammation in rat paw. Low-level laser therapy (LLLT) has been observed to reduce pain in inflammatory disorders. However, little is known about the mechanisms behind this effect or whether it is wavelength-specific. The test sample consisted of 32 rats divided into four groups: A(1) (control-saline), A(2) (carrageenan-only), A(3) (carrageenan + 660 nm laser therapy), and A(4) (carrageenan + 684 nm laser therapy). The animals from groups A(3) and A(4) were irradiated 1 h after induction of inflammation by carrageenan injection. Continuous-wave red lasers with wavelengths of 660 and 684 nm and dose of 7.5 J/cm(2) were used. Both the 660 nm and 684 nm laser groups had 30%-40% lower mRNA expression for cytokines TNF-alpha, IL-1beta, and IL-6 in the paw muscle tissue than t...
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Objective: Low level laser therapy (LLLT) has been forwarded as therapy for osteoarthritis and tendinopathy. Results in animal and cell studies suggest that LLLT may act through a biological mechanism of inflammatory modulation. The... more
Objective: Low level laser therapy (LLLT) has been forwarded as therapy for osteoarthritis and tendinopathy. Results in animal and cell studies suggest that LLLT may act through a biological mechanism of inflammatory modulation. The current study was designed to investigate if LLLT has an anti-inflammatory effect on activated tendinitis of the Achilles tendon. Methods: Seven patients with bilateral Achilles tendonitis
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Research Interests: Risk, Radiation Therapy, Humans, Cancer Therapy, Head and Neck Cancer, and 14 moreConfidence intervals, Supportive Care, Standardisation, Cancer Chemotherapy, Low Level Laser Therapy, Meta Analysis, Systematic review, Infrared, Stomatitis, Randomized Controlled Trial, Oral mucositis, Side Effect, Antineoplastic Agents, and Relative Risk
The aim of the present study was to profile shoulder passive range of motion (ROM) and isometric strength for external (ER) and internal (IR) rotation as part of a preseason screening in adolescent national badminton players. Passive... more
The aim of the present study was to profile shoulder passive range of motion (ROM) and isometric strength for external (ER) and internal (IR) rotation as part of a preseason screening in adolescent national badminton players. Passive external range of motion (EROM) and internal range of motion (IROM) were examined on the dominant and nondominant shoulder in 31 adolescent national badminton players (12 females and 19 males) with a standard goniometer. Muscle strength was examined with a hand-held dynamometer in ER and IR. Total range of motion (TROM = EROM+IROM) was lower on the dominant side compared with the nondominant side in both groups (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001). Males were generally stronger than females in all strength measurements except for IR on the dominant side (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.01). In females, IR dominant side strength was greater compared with IR on the nondominant side (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05). TROM was reduced on the dominant side compared with the nondominant side in young elite badminton players, irrespective of gender. No rotational strength differences existed between the dominant and nondominant side in male players, but in female players a higher IR strength on the dominant side was not balanced by a higher ER strength.