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    L. Lhotska

    ABSTRACT Research and development have been speeding up in recent decades, especially in interdisciplinary and newly emerging areas. Since the students will be exposed to this situation immediately after graduation when they start their... more
    ABSTRACT Research and development have been speeding up in recent decades, especially in interdisciplinary and newly emerging areas. Since the students will be exposed to this situation immediately after graduation when they start their jobs it is desirable to involve them in research projects. Through this work they acquire new knowledge and skills they will need in the future jobs. Moreover, they are frequently participating in strongly interdisciplinary research that requires orientation not only in engineering disciplines, but also in the other concerned areas. One of the typical examples is the area of Biomedical Engineering. In this paper we will discuss several case studies of students' involvement in research and present their research results.
    In the paper we discuss our recent experience and lessons learned from education in interdisciplinary areas, such as biomedical engineering, cybernetics and robotics, and multimedia. We explain briefly the differences among these areas... more
    In the paper we discuss our recent experience and lessons learned from education in interdisciplinary areas, such as biomedical engineering, cybernetics and robotics, and multimedia. We explain briefly the differences among these areas concerning the individual disciplines and their mutual relations. Then we discuss the requirements resulting from new application areas of engineering and technology. Finally we describe our current
    Information and communication technologies have already become inseparable part of healthcare sector activities. In the paper we discuss the issues of standardization and interoperability that are crucial for correct interconnec-tion of... more
    Information and communication technologies have already become inseparable part of healthcare sector activities. In the paper we discuss the issues of standardization and interoperability that are crucial for correct interconnec-tion of medical and other devices and information systems. Our previous work in the area has led us to the conclusion that successful integration of partial solutions will be strongly de-pendent on the issue of interoperability of medical devices and information systems. It comprises problems of standardization of data acquisition, communication, processing, and storage; and connected problem: correct data mapping between differ-ent ICT applications.
    ABSTRACT A measurement of blood pressure is a basic diagnostic technique for examining of the cardiovascular system. There are a lot of methods for determination of the blood pressure, but an oscillometric measurement (investigation of... more
    ABSTRACT A measurement of blood pressure is a basic diagnostic technique for examining of the cardiovascular system. There are a lot of methods for determination of the blood pressure, but an oscillometric measurement (investigation of oscillometric pulsations) is one of the most frequent methods used in modern electronic tonometers. The results given by oscillometric measurements are very dependent on the cleanness of the signal. The method is very sensitive for example for motion artifacts, which produce significant damage of the signal. For the proper processing of the signal it is very important to detect all artifacts precisely before signal processing. The paper deals with the methods for artifacts detection in oscillometric pulsations signals. The methods based on predicted heart rate detection, heart rate variability (standard deviation method) and comparison of oscillometric pulsations with ECG signal are described in the paper. The section Results includes a comparison of the methods and a discussion of their advantages and disadvantages. The authors conclude that the algorithm based on detection of heart rate variability (standard deviation method) seems as the most suitable algorithm for automated detection of artifacts in the signal of oscillometric pulsations.
    In the paper we discuss our recent experience and lessons learned from education in interdisciplinary areas, such as biomedical engineering, cybernetics and robotics, and multimedia. We explain briefly the differences among these areas... more
    In the paper we discuss our recent experience and lessons learned from education in interdisciplinary areas, such as biomedical engineering, cybernetics and robotics, and multimedia. We explain briefly the differences among these areas concerning the individual disciplines and their mutual relations. Then we discuss the requirements resulting from new application areas of engineering and technology. Finally we describe our current
    ABSTRACT The paper presents in its initial part fundamental mathematical tools for analysis of retinal images using methods of digital signal processing and enhancement and methods for their registration to monitor changes during the... more
    ABSTRACT The paper presents in its initial part fundamental mathematical tools for analysis of retinal images using methods of digital signal processing and enhancement and methods for their registration to monitor changes during the treatment. Blood vessel trees are then extracted to analyse their specific structures to find retina disorders. The proposed graphical user interface is then used for analysis and monitoring of the set of 20 patients observed during the treatment using the optical coherence tomography. Features obtained are then analysed using selected statistical methods to compare features obtained and to propose the method for classification of healthy and diseased patients. The accuracy achieved was 79 %.
    The most popular and publicly well-known are the studies using the Body Mass Index (BMI) as a single parameter indicating the degree of obesity (or slimness). However BMI cannot tell anything about the body composition. The Body Impedance... more
    The most popular and publicly well-known are the studies using the Body Mass Index (BMI) as a single parameter indicating the degree of obesity (or slimness). However BMI cannot tell anything about the body composition. The Body Impedance Analysis (BIA) represents one of the methods for classification of body composition. As obesity does not refer to excessive body weight but it refers to the condition in which the individual has an excessive amount of body fat it is necessary to know distribution of fat tissue and fat-free mass in the body. The aim of the paper is to present results of our ongoing research focused on the influence of body hydration on the body impedance measurements and also on the influence of the frequency used for the measurement. The performed measurements showed certain influence which must be verified by repeated and extended experiments with greater number and variety of measured subjects.
    This paper provides an introduction to some of the most important challenges that may occur when introducing the principle of Personal Portable Devices for providing information in terms of Big Data on the one hand, and the concept of the... more
    This paper provides an introduction to some of the most important challenges that may occur when introducing the principle of Personal Portable Devices for providing information in terms of Big Data on the one hand, and the concept of the Virtual Physiological Human on the other. Both concepts can be applied to exploit their specific capability to collect and record personal health data of different levels of granularity into processes of personalized health service provision. The paper thus analyzes Big Data approaches and their capability to provide information for personalized service provision, and the same goes for the Virtual Physiological Human as such. But it is not only devices, concepts, models, and strategies that are involved in personalized health care as well as welfare and wellness service provision to human beings - it is the human being himself, too. This paper addresses technological and methodological aspects of using large amounts of data whereas another paper submitted to this conference will bring forward the aspects of applied sensor and device technology in relation to decision support and decision making for pHealth services.
    Research Interests:
    Formalization of the work practice using processes is a widely used method throughout various fields of industry. However, their application within the healthcare domain is rather unsuccessful due to the need for high agility, exceptions... more
    Formalization of the work practice using processes is a widely used method throughout various fields of industry. However, their application within the healthcare domain is rather unsuccessful due to the need for high agility, exceptions handling, and for working with complex medical knowledge that affects these processes. To overcome these problems the agent paradigm and multi-agent systems can be applied. In this paper we present a novel architecture of a multi-agent system that is able to work with general processes. As an exemplary application of the architecture we describe a critiquing decision support system for healthcare specialists based on formalized medical guidelines.
    ... Dynamic Time Warping The Derivative dynamic warping metrics (DDTW) is a modifi-cation of the classical dynamic time warping (DTW) algorithm The DTW algorithm technique allows comparison ... Figure 2 shows an example of time warping... more
    ... Dynamic Time Warping The Derivative dynamic warping metrics (DDTW) is a modifi-cation of the classical dynamic time warping (DTW) algorithm The DTW algorithm technique allows comparison ... Figure 2 shows an example of time warping measure applied to two ECG beats. ...
    1 Dept. of Communications, Informatics and Management, TEI of Epirus, Kostakioi, Artas, Greece 2 Czech Technical University, Gerstner Laboratory, Prague, Czech Republic 3Department of Gynecology and Obstetrics, Porto Faculty of Medicine,... more
    1 Dept. of Communications, Informatics and Management, TEI of Epirus, Kostakioi, Artas, Greece 2 Czech Technical University, Gerstner Laboratory, Prague, Czech Republic 3Department of Gynecology and Obstetrics, Porto Faculty of Medicine, Porto, Portugal
    A decision tree is a good classifier with a transparent decision mechanism. Decision-tree building methods usually have problems in splitting the learning samples into more subsets, because of the nature of the tree. If the classification... more
    A decision tree is a good classifier with a transparent decision mechanism. Decision-tree building methods usually have problems in splitting the learning samples into more subsets, because of the nature of the tree. If the classification into such subsets is not possible, it is better to put the classification decision on to some other classifier. This leads to the introduction of a null classification, which simply means that no classification is possible in this step. This approach is sensible with evolutionary methods, as they can handle a number of trees simultaneously. In the process of construction, we have to address the problem of whether a classification is sensible. The performance of the proposed model has been tested on several data sets and the results presented on one such data set show its potential
    Measures from the theory of nonlinear dynamics were applied on complex fractionated atrial electrograms (CFAEs) in order to characterize their physiological dynamic behavior. The results were obtained considering 113 short term atrial... more
    Measures from the theory of nonlinear dynamics were applied on complex fractionated atrial electrograms (CFAEs) in order to characterize their physiological dynamic behavior. The results were obtained considering 113 short term atrial electrograms (A-EGMs) which were annotated by three experts into four classes of fractionation according to A-EGMs signal regularity. The following measures were applied on A-EGM signals: General Correlation Dimension, Approximate Entropy, Detrended Fluctuation Analysis, Lempel-Ziv Complexity, and Katz-Sevcik, Variance and Box Counting Fractal Dimension. Assessment of disorganization was evaluated by a Kruskal Wallis statistical test. Except Detrended Fluctuation Analysis and Variance Fractal Dimension, the CFAE disorganization was found statistically significant even for low significant level alpha = 0.001. Moreover, the increasing complexity of A-EGM signals was reflected by higher values of General Correlation Dimension of order 1 and Approximate En...
    A robust, automated classification system for polysomnographic (PSG) data targeted to the newborn sleep stage identification is presented. The problem of polysomnographic signal classification is very often difficult because of artifacts... more
    A robust, automated classification system for polysomnographic (PSG) data targeted to the newborn sleep stage identification is presented. The problem of polysomnographic signal classification is very often difficult because of artifacts and noise. Furthermore, for each signal, a special classification method for each particular type of segment must be mostly used. This paper proposes fully unsupervised approach using adaptive segmentation, appropriate features extraction and hierarchical clustering (Ward’s minimumvariance method is used). The mutual information concept was applied to results of hierarchical clustering. The proposed procedure was tested on real neonatal data. All sleep states were successfully separated by a combination of EEG, EMG, EOG, PNG and ECG channels.
    The ratio of three newborn’s behavioral states – wakefulness, active sleep and quiet sleep – is an important indicator of the maturity of the newborn brain in clinical practice. This paper presents study undertaken to identify possible... more
    The ratio of three newborn’s behavioral states – wakefulness, active sleep and quiet sleep – is an important indicator of the maturity of the newborn brain in clinical practice. This paper presents study undertaken to identify possible improvements in processing of neonatal sleep electroencephalographic recordings. The influence of segmentation, feature extraction and feature selection on the classification accuracy was examined. The total of 97 features was extracted for each EEG channel for each segment. For selection of individual features from different channels, sequential methods were used. Naive Bayes classifier was used for final classification and performance was evaluated through cross validation. Experiments show that the combination of adaptive segmentation and selected features led to better performance. Obtained results may provide a reference for developing or enhancing neonatal sleep EEG classification algorithms. Analysis was performed on real clinical data.

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