Laboratory technologies of synthesis of composite nanoparticles containing plasmon resonant core ... more Laboratory technologies of synthesis of composite nanoparticles containing plasmon resonant core (gold nanospheres, nanoshells, nanorods and gold-silver nanocages) and silica shell doped with photosensitizer with tuning of optical properties in visible and infrared regions were developed. Composite nanoparticles were utilized for effective combined photothermal and photodynamic inactivation of pathogenic bacteria and grafted tumors in rats. New types of nanomaterials – powders of gold and gold-silver nanoparticles easy soluble in water media without any additional manipulations and maintaining all properties of parent colloids were synthesized. The nanopowders were investigated with in vitro and in vivo experimental models for the first time. The nanoparticle powders can be stored for a long time under usual conditions which significantly simplifies the transfer of laboratory technologies to clinics. In particular, of the gold nanorod powders were used for photothermolysis of xenogr...
Using surface-enhanced infrared absorption (SEIRA) spectroscopy of dry films of colloidal gold (C... more Using surface-enhanced infrared absorption (SEIRA) spectroscopy of dry films of colloidal gold (CG) bioconjugates with protein A, it is shown that certain characteristic bands of the protein (e.g., amide I, amide II and some other vibration modes) are essentially affected by the metal surface. Thus, the method may be used for controlling the quality of such bioconjugates. Moreover, it is
Laboratory technologies of synthesis of composite nanoparticles containing plasmon resonant core ... more Laboratory technologies of synthesis of composite nanoparticles containing plasmon resonant core (gold nanospheres, nanoshells, nanorods and gold-silver nanocages) and silica shell doped with photosensitizer with tuning of optical properties in visible and infrared regions were developed. Composite nanoparticles were utilized for effective combined photothermal and photodynamic inactivation of pathogenic bacteria and grafted tumors in rats. New types of nanomaterials – powders of gold and gold-silver nanoparticles easy soluble in water media without any additional manipulations and maintaining all properties of parent colloids were synthesized. The nanopowders were investigated with in vitro and in vivo experimental models for the first time. The nanoparticle powders can be stored for a long time under usual conditions which significantly simplifies the transfer of laboratory technologies to clinics. In particular, of the gold nanorod powders were used for photothermolysis of xenogr...
Using surface-enhanced infrared absorption (SEIRA) spectroscopy of dry films of colloidal gold (C... more Using surface-enhanced infrared absorption (SEIRA) spectroscopy of dry films of colloidal gold (CG) bioconjugates with protein A, it is shown that certain characteristic bands of the protein (e.g., amide I, amide II and some other vibration modes) are essentially affected by the metal surface. Thus, the method may be used for controlling the quality of such bioconjugates. Moreover, it is
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Papers by Lev Dykman