Research Interests:
Burns are still considered one of the most devastating conditions in emergency medicine affecting both genders and all age groups in developed and developing countries, resulting into physical and psychological scars and cause chronic... more
Burns are still considered one of the most devastating conditions in emergency medicine affecting both genders and all age groups in developed and developing countries, resulting into physical and psychological scars and cause chronic disabilities. This study was performed to determine the healing effect of curcumin on burn wounds in rat. Seventy female Sprague-Dawley 180-220 g rats were randomly divided into 5 equal groups. Groups of A-C received 0.1, 0.5 and 2% curcumin respectively and Group D, silver sulfadiazine ointment. Group E was considered as control group and received eucerin. After 7, 14 and 21 days of therapy, the animals were sacrificed and burn areas were macroscopically examined and histologically were scored. Administration of curcumin resulted into a decrease in size of the burn wounds and a reduction in inflammation after 14(th) days. Reepithelialization was prominent in groups A-C while more distinguishable in group C. In group C, epidermis exhibited well structu...
As a serious neuropsychiatric disease, hepatic encephalopathy (HE) is a clinical condition with several types regarding chronicity and clinical diversity that can develop as a complication of both acute and chronic liver failure. This... more
As a serious neuropsychiatric disease, hepatic encephalopathy (HE) is a clinical condition with several types regarding chronicity and clinical diversity that can develop as a complication of both acute and chronic liver failure. This study evaluates changes in thioacetamide (TAA)-induced acute hepatic encephalopathy (AHE) in rat as an animal model. Both genders of C57BL6, BALB/C mice and Sprague Dawley rats; (10 animals in each group) were compared for induction of AHE to clarify which animal and gender were appropriate. The animals (10 male rats in each group) were categorized in 4 groups according to the dose of the TAA administered (200, 300 and 400 mg/kg of TAA at 24 h intervals for 4 days). A control group was treated with solvent of TAA which was water (5 ml/kg/day). The behavioral, biochemical markers of hepatic failure and histological aspects of thioacetamide (TAA) induced AHE and the correlation between the clinical severity and liver failure biomarkers were evaluated. Ra...
Research Interests: Genetics, Psychopharmacology, Personality, Depression, Schizophrenia, and 48 morePolymorphism, Asthma, General Internal Medicine, Japan, Chronic Fatigue Syndrome, Behavioral Medicine, Psychiatric Genetics, Anxiety, Biological Sciences, Biological Psychiatry, Serotonin, PCR, Prospective studies, Humans, Affective Disorders, Smoking, Neurotic Disorders, Female, Serotonin Transporter, Male, Polymerase Chain Reaction, Genetic Association Studies, HPA axis, Membrane transport proteins, Clinical Sciences, HT, Aged, Middle Aged, Gene Polymorphism, Genomic DNA, Genotype, Adult, Coronary heart disease, Public health systems and services research, Analysis of Variance, Asian Continental Ancestry Group, Transporter, Genetic variation, Chi Square Distribution, Psychiatric, ANXIETY, Harm Avoidance, Cross Sectional Studies, Archives General Psychiatry, Neurosciences, Biochemistry and cell biology, Cohort Studies, and Personality Trait
Research Interests:
Research Interests: Genetics, Psychopharmacology, Personality, Depression, Schizophrenia, and 48 morePolymorphism, Asthma, General Internal Medicine, Japan, Chronic Fatigue Syndrome, Behavioral Medicine, Psychiatric Genetics, Anxiety, Biological Sciences, Biological Psychiatry, Serotonin, PCR, Prospective studies, Humans, Affective Disorders, Smoking, Neurotic Disorders, Female, Serotonin Transporter, Male, Polymerase Chain Reaction, Genetic Association Studies, HPA axis, Membrane transport proteins, Clinical Sciences, HT, Aged, Middle Aged, Gene Polymorphism, Genomic DNA, Genotype, Adult, Coronary heart disease, Public health systems and services research, Analysis of Variance, Asian Continental Ancestry Group, Transporter, Genetic variation, Chi Square Distribution, Psychiatric, ANXIETY, Harm Avoidance, Cross Sectional Studies, Archives General Psychiatry, Neurosciences, Biochemistry and cell biology, Cohort Studies, and Personality Trait
Neurodegeneration is the pathophysiological basis for permanent neurological disabilities in multiple sclerosis (MS); thus neuroprotection is emerging as a therapeutic approach in MS research. Modulation of excitotoxicity by inhibition of... more
Neurodegeneration is the pathophysiological basis for permanent neurological disabilities in multiple sclerosis (MS); thus neuroprotection is emerging as a therapeutic approach in MS research. Modulation of excitotoxicity by inhibition of NMDARs has been suggested for neuroprotection, but selective antagonisation of the NR2B subtype of these receptors, a subtype believed to play a more pivotal role in neurodegeneration, has not been tested in MS. In this study inhibition of NR2B-containing NMDAR was evaluated on the animal model of MS, experimental autoimmune encephalomyelitis (EAE). EAE induction was done using MOG in C57BL/6 mice. Therapeutic administration of different doses of highly selective NR2B-containing NMDAR inhibitor (RO25-6981) was compared with memantine (non-selective NMDAR antagonist) and vehicle. Neurological deficits in EAE animals were more efficiently decreased by selective inhibition of NR2B-containing NMDARs. Histological studies of the spinal cords also showed...