This study investigated the allelopathic, genotoxic and cytotoxic effects of the tuber extracts o... more This study investigated the allelopathic, genotoxic and cytotoxic effects of the tuber extracts of Dioscorea dumetorum. This was with a view to eventually identifying herbicides and anti-tumor compounds from the plant. Methanol extract and hexane fraction of pulverized D. dumetorum was obtained. Tests for allelopathy, genotoxicity and cytotoxicity were carried out, along with proline content, total protein and total sugar assays. The hexane fraction exhibited a potent growth inhibitory effect. The inhibition increased from 42% at 15 mg/ml to 92% at 60 mg/ml of the fraction. The methanolic extract was less potent than the hexane fraction, the inhibition increased from 25% at 20 mg/ml to 75% at 80 mg/ml. The extract and fraction also inhibited seed germination in a dose-dependent manner. Genotoxicity studies using Allium cepa showed different chromosomal aberrations like fragmentation, cell with bloated nucleus, fuzzy chromosome, puffy chromosome, chromatin erosion, late condensation ...
This study investigated the allelopathic, genotoxic and cytotoxic effects of the tuber extracts o... more This study investigated the allelopathic, genotoxic and cytotoxic effects of the tuber extracts of Dioscorea dumetorum. This was with a view to eventually identifying herbicides and anti-tumor compounds from the plant. Methanol extract and hexane fraction of pulverized D. dumetorum was obtained. Tests for allelopathy, genotoxicity and cytotoxicity were carried out, along with proline content, total protein and total sugar assays. The hexane fraction exhibited a potent growth inhibitory effect. The inhibition increased from 42% at 15 mg/ml to 92% at 60 mg/ml of the fraction. The methanolic extract was less potent than the hexane fraction, the inhibition increased from 25% at 20 mg/ml to 75% at 80 mg/ml. The extract and fraction also inhibited seed germination in a dose-dependent manner. Genotoxicity studies using Allium cepa showed different chromosomal aberrations like fragmentation, cell with bloated nucleus, fuzzy chromosome, puffy chromosome, chromatin erosion, late condensation ...
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Papers by Oluwole Taiwo