Time in Therapeutic Range (TTR) is a value used to assess the efficacy of Warfarin treatment. The aim of our study is to determine the effective INR levels and the rate of TTR in patients on Warfarin regimen due to Atrial Fibrillation... more
Time in Therapeutic Range (TTR) is a value used to assess the efficacy of Warfarin treatment. The aim of our study is to determine the effective INR levels and the rate of TTR in patients on Warfarin regimen due to Atrial Fibrillation (AF) or Mechanical Prosthetic Valve (MPV). A total of 94 patients (58 female, and 36 male, mean age: 64.9±11years) on Warfarin treatment due to AF or MPV with at least 10 INR levels measurements in the last 6 months were included in this retrospective study. The patients were divided into 2 groups. Group 1 consisted of the patients with Valvular AF (n=47); Group 2 included the patients with Non-Valvular AF (n=47); TTR and INR levels were compared. The average of INR values were found as 2,4 (min: 1,3, max: 4,3) in all patients; 2,3 (min: 1,3, max: 4,2) in Group 1; 2,6 (min: 1,3, max: 4,3) in Group 2. The average of TTR values was found 40.3% (min: 10%, max: 80%) in all patients; 43.8% (min: 10%, max: 80%) in Group 1; 36,8% (min: 10%, max: 80%) in Group 2. INR and TTR values are needed to assess the effectiveness of the Warfarin treatment. The patients in treatment with Warfarin should be well trained and frequently monitored. On the other hand, the underlying factors of the TTR values being determined as lower in the Turkish patient population might be due to the lower socio-economic and socio-cultural status, inadequate education levels, and the insufficient information on use of the medication provided by the doctors to the patients.
Research Interests:
Research Interests:
Research Interests: Medicine and Gynecology
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests: Medicine and Gynecology
... Murat Atmaca*, İmdat Dilek**, Burçak Atmaca***, A.Cumhur Dülger****, Eyüp Taşdemir ... nöropati, nefropati gibi spesifik bulgularla tanınabilir (2). Kronik komplikasyonların gelişiminde diabet süresi, hastanın yaşı, cinsiyet, genetik... more
... Murat Atmaca*, İmdat Dilek**, Burçak Atmaca***, A.Cumhur Dülger****, Eyüp Taşdemir ... nöropati, nefropati gibi spesifik bulgularla tanınabilir (2). Kronik komplikasyonların gelişiminde diabet süresi, hastanın yaşı, cinsiyet, genetik yatkınlık, ırk ve kötü kan şekeri regülâsyonu gibi ...
Research Interests:
Research Interests:
Research Interests:
Research Interests: Medicine and Gynecology
Kardiyovaskuler Hastaliklar (KVH) dunya genelinde olumlerin en sik nedenidir. Dunyadaki tum olumlerin %31’ini olusturmaktadir. KVH icin sigara kullanimi, sagliksiz beslenme, obezite, fi ziksel inaktivite, yuksek kan basinci... more
Kardiyovaskuler Hastaliklar (KVH) dunya genelinde olumlerin en sik nedenidir. Dunyadaki tum olumlerin %31’ini olusturmaktadir. KVH icin sigara kullanimi, sagliksiz beslenme, obezite, fi ziksel inaktivite, yuksek kan basinci (hipertansiyon), yuksek kan yaglari ve diyabet gibi risk faktorleri mevcuttur Vucudun deri, agiz, vajina, bagirsaklar gibi cesitli bolgelerinde yerlesmis bakterilere o bolgenin “florasi”, yeni adiyla “mikrobiyota”si denmektedir. Mikroorganizmalarin genomuna ise “mikrobiyom” adi verilmektedir. Insan vucudu %10 kendi hucresi ve % 90’i mevcut konaga yerlesmis mikrobiya hucrelerden olusmaktadir. Intestinal mikrobiyota; vucudumuzda fi zyolojik, metabolik ve immun sistem uzerinde oldukca onemli gorevler ustlenmektedir. Enerji tasiyici rolu ustlenerek veya immun module edici maddeleri serbest birakarak gerekli metabolik surecleri kontrol eden bagirsak bakterileri bu nedenle gunumuzde yeni bir “metabolik organ” olarak tanimlanmaktadir. Bagirsak Mikrobiyotasi ile son done...
Research Interests: Medicine and Gynecology
Tum dunyada yasli nufusu artmaktadir. Yasla beraber kronik hastalik sikligi ve ilac kullanim sikligi da artmaktadir. Yasli hastalarda cok fazla ilac kullanimi olmaktadir. Ilaclarin yan etkileri yasli hastalarda daha sik gorulmektedir.... more
Tum dunyada yasli nufusu artmaktadir. Yasla beraber kronik hastalik sikligi ve ilac kullanim sikligi da artmaktadir. Yasli hastalarda cok fazla ilac kullanimi olmaktadir. Ilaclarin yan etkileri yasli hastalarda daha sik gorulmektedir. Gelismis ulkelerin bir cogunda yasli hastalar icin hangi ilcalarin daha uygun oldugunu gosteren listeler belirlenmistir. Bu listeler baz alinarak yasli hastalarin kullanmasi uygun olmayan ilaclar tespit edilerek, daha az yan etkisi olan daha uygun ilaclar ile degistirilmektedir. PRISCUS ilac listesinde ilk kez 2010 yilinda Almanya’da kullanilmaya baslanan daha sonrada revize edilen yasli hastalarda kullanimi uygun olmayan ilaclari gosteren bir listedir. Biz bu derlememizde PRISCUS listesi, yaslilarda coklu ilac ve uygunsuz ilac kullanimi ve u hakkinda bilgi vermeyi amacladik.
Research Interests: Medicine and Gynecology
Aortik arkin dallanma paternindeki varyasyonlari bilmek bas-boyun cerrahisi, vaskuler cerrahi, tanisal anjiografi ve girisimsel islemlerde klinik oneme sahiptir. Aortik ark dallanmalarindaki varyasyonlar anjiografi , bilgisayarli... more
Aortik arkin dallanma paternindeki varyasyonlari bilmek bas-boyun cerrahisi, vaskuler cerrahi, tanisal anjiografi ve girisimsel islemlerde klinik oneme sahiptir. Aortik ark dallanmalarindaki varyasyonlar anjiografi , bilgisayarli tomografi yada kadavra kesitlerinde cogunlukla rastlantisal olarak fark edilir cunku cogu vakada hastalar asemptomatiktir. Vertebral arterler subclavien arterin ilk bolumunun superioposteriorundan cikarlar. Sol ve sag vertebral arterler uzunluk ve genislik olarak birbirlerinden farklidirlar. Sol vertebral arterin subclavien arter yerine aortik arktan direk ciktigi vakalar oldukca nadirdir. Bu olgu sunumunda 52 yasinda bir bayan hastada saptanan sol subklaviyen arter cikis anomalisi tartisilmistir.
Research Interests:
Background: Restless Legs Syndrome (RLS) is a sensory-motor neurological disease characterized by discomfort, unpleasant sensations, an urge to move the legs. There are a lot of studies showing the association between Restless Legs... more
Background: Restless Legs Syndrome (RLS) is a sensory-motor neurological disease characterized by discomfort, unpleasant sensations, an urge to move the legs. There are a lot of studies showing the association between Restless Legs Syndrome (RLS), Cardiovascular Diseases (CVD), Hypertension (HT) and Body Mass Index (BMI). The potential underlying mechanism of an increased risk of CVD in RLS is not clear but may involve hypertension, as Periodic Limb Movements during Sleep (PLMS) were shown to be related to blood pressure increases. These studies were inconsistent. The aim of this case control study was to show the prevalence of CVD in the patients with RLS compared with a control group.Methods: A total of 37 newly diagnosed patients with RLS (group 1) who were applied to neurology polyclinic of Sakarya University Hospital between March 2016 and May 2017 and 37 control subjects (group 2) were included in this case control study. RLS was diagnosed using the criteria of the Internation...
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Background: The pathogenesis of irritable bowel syndrome (IBS) has not been fully elucidated. The gastrointestinal tract have a well-differentiated intrinsic nervous system and also this system is connected with nervous system. The... more
Background: The pathogenesis of irritable bowel syndrome (IBS) has not been fully elucidated. The gastrointestinal tract have a well-differentiated intrinsic nervous system and also this system is connected with nervous system. The symptoms of IBS are related with autonomic nervous system (ANS). It was also possible to see cardiovascular symptoms due to this link. This link can influence QT dispersion (QTd). The aim of this case control study is to show the cardiac effects of IBS by changes in QTd.Methods: There were 56 newly diagnosed patients with IBS and 60 control subjects were included in this study. IBS was diagnosed using the new Roma IV Criterias. Standard 12-lead electrocardiogram (ECG) were taken in both two groups. QTd and corrected QTd (QTcd), QT max, QT min, QT avarage, Corrected QT (QTc) min, QTc max, QTc avarage values were calculated with Bazzet Formula from rest ECGs.Results: There were 56 newly diagnosed patients with IBS and 60 control subjects were included in th...
Research Interests:
Aims: It is known that the angle between the aorta and the septum on the long axis in two-dimensional echocardiography is different between individuals in the community. The relationship between aortoseptal angle (AoSA), age and diastolic... more
Aims: It is known that the angle between the aorta and the septum on the long axis in two-dimensional echocardiography is different between individuals in the community. The relationship between aortoseptal angle (AoSA), age and diastolic dysfunction has been mentioned in a couple of articles. We aimed to investigate if this angle is directly related to duration of hypertension (HT), regardless of age factor. Method: The data of 1294 patients who applied to the cardiology outpatient clinic and whose AoSAs were recorded and analyzed retrospectively. SPSS 20 was entered and the correlation of AoSA with age, duration of HT and other data was investigated. Results: A significant correlation was found between AoSA, duration of HT, age, and diameter of the ascending aorta. A partial correlation was sought for when age was taken under control, and then a significant correlation was found between AoSA, duration of HT and diameter of the ascending aorta. Conclusion: Aorta is known to lengthe...
Research Interests:
Acute myocardial infarction due to simultaneous occlusions of the left anterior descending artery
Cardiovascular Diseases (CVD) are the most common cause of death in worldwide It accounts for 31% of all deaths in the world. Risk factors for CVD are smoking, unhealthy diet, obesity, physical inactivity, high blood pressure... more
Cardiovascular Diseases (CVD) are the most common cause of death in worldwide It accounts for 31% of all deaths in the world. Risk factors for CVD are smoking, unhealthy diet, obesity, physical inactivity, high blood pressure (hypertension), high blood fat and diabetes Bacteria that have been settled in various parts of the body such as skin, mouth, vagina, intestines are called “fl oras”, new name is called “microbiota”. The genome of microorganisms is called “ microbiome “ The human body is composed of 10% of its own cells and 90% of the existing microbial cells.Intestinal microbiota; carries out very important tasks on the physiological, metabolic and immunological systems in our body.Intestinal bacteria that control the necessary metabolic processes by assuming the role of energy carrier or releasing immunomodulating substances because of this it is now defi ned as a new “metabolic organ”. Recent studies with intestinal microbiology have shown that microbiota is associated with ...
Enerji icecekleri ozellikle 15-25 yas arasi gencler tarafindan tuketilen, fi ziksel ve mental performansi arttirdigi varsayilan urunlerdir. Ogrenciler ve uzun yol soforleri tarafindan uykuyu kacirmak, sporcular tarafindan fi ziksel... more
Enerji icecekleri ozellikle 15-25 yas arasi gencler tarafindan tuketilen, fi ziksel ve mental performansi arttirdigi varsayilan urunlerdir. Ogrenciler ve uzun yol soforleri tarafindan uykuyu kacirmak, sporcular tarafindan fi ziksel performansi arttirmak, alkol alan kisilerce de emosyonel durumu dengelemek ve cinsel performansi arttirmak amaciyla kullanilir. Enerji iceceklerinin vucut uzerine etkileri icerdikleri kafein, inositol, taurin, glukuronolakton gibi maddelere baglidir fakat enerji icecekleri ve yan etkileri ile ilgili literatur bilgileri kisitlidir. Biz bu makalede enerji icecekleri hakkinda genel bir bilgi vermek, etkileri ve yan etkileri ile ilgili literatur bilgilerini paylasmak istedik. Anahtar Kelimeler: Enerji icecegi, yan etki, kafein
Research Interests:
Research Interests:
Research Interests:
Pericardial effusion and cardiac tamponade is a complication often seen in patients with advanced lung disease. However, pericardial effusion and cardiac tamponade is a rare form of presentation of lung cancer as the first finding.... more
Pericardial effusion and cardiac tamponade is a complication often seen in patients with advanced lung disease. However, pericardial effusion and cardiac tamponade is a rare form of presentation of lung cancer as the first finding. 52-year-old male patient presented with a sudden onset dyspnea to emergency service. There was a significant cardiomegaly in patient’s telecardiography and was showed an image compatible with massive pericardial effusion and cardiac tamponade in echocardiography. The patient's condition improved with emergency pericardiocentesis. Biopsies were taken from the neck lymph nodes seen on thorax CT. Biopsy was consistent with large cell lung cancer. Malignancy should be considered in patients with pericardial effusion and cardiac tamponade. For the first time in this case, lung cancers are discussed in a patient with massive pericardial effusion and cardiac tamponade.
Patients with carotid disease are frequently referred for carotid artery stenting based on the results of carotid duplex studies. During carotid artery stenting, the stent is usually extended into the common carotid artery, thereby... more
Patients with carotid disease are frequently referred for carotid artery stenting based on the results of carotid duplex studies. During carotid artery stenting, the stent is usually extended into the common carotid artery, thereby crossing the external carotid artery. Previous studies have shown conflicting results regarding internal carotid stenting and external carotid artery flow velocities, but the effect of stenting on ipsilateral superior thyroid artery velocities has not been defined. This study examined the effect of internal carotid angioplasty and stenting on the ipsilateral superior thyroid artery Doppler-derived flow parameters. We prospectively studied preinterventional and postinterventional duplex scans obtained from 41 patients (mean age ± SD, 64 ± 10 years) who underwent carotid artery stenting. The Doppler-defined preprocedural peak systolic velocity (PSV) end-diastolic velocity (EDV), resistive index (RI), and pulsatility index (PI) in the ipsilateral external carotid and superior thyroid arteries were compared with postprocedural values. Among patients with stenting, the preprocedural PSV, EDV, RI, and PI in the ipsilateral superior thyroid artery were 30 ± 11 cm/s, 13 ± 6 cm/s, 0.62 ± 0.11, and 1.04 ± 0.28,respectively; after stenting, they were 36 ± 8 cm/s, 14 ± 9 cm/s, 0.71 ± 0.07, and 1.11 ± 0.19. The preprocedural PSV, EDV, RI, and PI in the ipsilateral external carotid artery were 79 ± 24 cm/s, 17 ± 7 cm/s, 0.77 ± 0.26, and 1.27 ± 0.22; after stenting, they were 94 ± 31 cm/s, 20 ± 6 cm/s, 0.80 ± 0.4, and 1.25 ± 0.31. Despite a slight increase in superior thyroid and external carotid artery flow, there was no statistically significant change from before to after stenting. This study showed no differences in blood velocity profiles in the ipsilateral superior thyroid and external carotid arteries after stenting.
Research Interests:
Research Interests: Risk assessment, Medicine, Humans, Female, Male, and 15 moreMetals, Aged, Middle Aged, Percutaneous Coronary Intervention, Coronary Angiography, Retrospective Studies, Risk Factors, Risk Assessment, prosthesis Design, Platelet Count, Area Under Curve, Predictive value of tests, Restenosis, Medical and Health Sciences, and Cardiovascular medicine and haematology
AIM: This study aimed to evaluate the cardiac autonomic dysfunction and the cardiac arrhythmia risk using heart rate variability parameters in subjects with vitamin D deficiency and low cardiovascular risk.MATERIAL AND METHODS: One... more
AIM: This study aimed to evaluate the cardiac autonomic dysfunction and the cardiac arrhythmia risk using heart rate variability parameters in subjects with vitamin D deficiency and low cardiovascular risk.MATERIAL AND METHODS: One hundred five consecutive individuals, 54 patients with low vitamin D status and 51 healthy controls were enrolled in this study. The overall cardiac autonomic tone was quantified by using various heart rate variability parameters included mean RR interval, mean Heart Rate, mean of standard deviations of intervals for 24 hours (SDNN), standard deviation of averages of intervals (SDANN), mean of standard deviation of intervals for 5 minutes (SDNNI), root mean square of difference of successive intervals (rMSSD) and the proportion of intervals differing more than 50 ms (pNN50) values. The 12-lead ECG was recorded from each participant, and QT intervals were measured.RESULTS: Baseline demographic profiles were similar between two groups. The heart rate variab...
Research Interests:
To evaluate the left (LV) and right (RV) ventricular function in euthyroid Hashimoto's thyroiditis (eHT) patients. Forty five (45) patients diagnosed with euthyroid... more
To evaluate the left (LV) and right (RV) ventricular function in euthyroid Hashimoto's thyroiditis (eHT) patients. Forty five (45) patients diagnosed with euthyroid Hashimoto's thyroiditis (eHT) and age and gender-matched forty five (45) control subjects were enrolled in this study. Echocardiographic parameters reflecting RV and LV functions such as; chamber dimensions, ejection fraction, fractional shortening, conventional and tissue Doppler derived early and late filling velocities (E, A, E', A'), isovolumic relaxation (IVRT) and contraction (IVCT) times, ejection time (ET), deceleration time (DT), Tei index, pulmonary acceleration time (PAcT) and tricuspid annular plane systolic excursion (TAPSE) of patients with eHT and were compared to control subjects using paired-samples t-test or Wilcoxon signed rank test. Regarding the LV function, patients with eHT compared to controls, had higher LV-Tei index (0.6±0.2 vs 0.4±0.1, p<0.001), DT(p<0.001), IVRT(p<0.001), and E/E' ratio (p=0.04). In contrast, the peak E wave velocity (p=0.02), E/A ratio (p=0.01) and ejection time (p=0.02) were significantly lower in the eHT group than control. For the RV, Tei index (0.40±0.11 vs 0.28±0.07, p<0.001), TAPSE (2.0±0.3 vs 2.2±0.2 mm, p<0.001), PAcT (124.3±22.6 vs 149.4±18.3 msec, p<0.001), A' (p=0.007) and IVCT (p=0.001) were significantly higher in patients with eHT than control. However, tricuspid E/A ratio (p=0.01), E' (p=0.03) and E'/A' ratio (p=0.001) were significantly lower in the eHT than control group. This study demonstrated that both RV and LV functions were impaired in patients with eHT.