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Priyanka Thakur

    Priyanka Thakur

    This report describes the case of an elderly gentleman who presented with sudden onset bilateral upper limb radiculopathy and neck stiffness. On neck radiography, erosion of the fourth cervical vertebral body was seen. Further evaluation... more
    This report describes the case of an elderly gentleman who presented with sudden onset bilateral upper limb radiculopathy and neck stiffness. On neck radiography, erosion of the fourth cervical vertebral body was seen. Further evaluation revealed the cause to be a moderately differentiated squamous cell carcinoma of the posterior pharyngeal wall. In spite of prompt initiation of radiation therapy with concurrent steroids, the patient died of progressive disease within 3 weeks of initial presentation.
    A decade ago, lung cancer could conveniently be classified into two broad categories-either the small cell lung carcinoma (SCLC), or the non-small cell lung carcinoma (NSCLC), mainly to assist in further treatment related decision making.... more
    A decade ago, lung cancer could conveniently be classified into two broad categories-either the small cell lung carcinoma (SCLC), or the non-small cell lung carcinoma (NSCLC), mainly to assist in further treatment related decision making. However, the understanding regarding the eligibility of adenocarcinoma histology for treatments with agents such as pemetrexed and bevacizumab made it a necessity for NSCLC to be classified into more specific sub-groups. Then, the availability of molecular targeted therapy with oral tyrosine kinase inhibitors (TKIs) such as gefitinib and erlotinib not only further emphasized the need for accurate sub-classification of lung cancer, but also heralded the important role of molecular profiling of lung adenocarcinomas. Given the remarkable advances in molecular biology, oncology and radiology, a need for felt for a revised classification for lung adenocarcinoma, since the existing World Health Organization (WHO) classification of lung cancer, published ...