Encephalitis is a condition with a variety of etiologies, clinical presentations and degrees of severity. The causes of these disorders include both neuroinfections and autoimmune diseases in which host antibodies are pathologically... more
Encephalitis is a condition with a variety of etiologies, clinical presentations and degrees of severity. The causes of these disorders include both neuroinfections and autoimmune diseases in which host antibodies are pathologically directed against self antigens. In autoimmune encephalitis, autoantibodies are expressed in the central nervous system. The incidence of this disease is approximately 4% of all reported cases of encephalitis. Autoimmune encephalitis can be induced by antibodies against neuronal surface antigens such as N-methyl-D-aspartate-activated glutamate receptors (NMDAR), ⍺-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors (AMPAR) or gangliosides GQ1b, DPPX, CASPR2, LGI1, as well as by antibodies against neuronal intracellular antigens. The paper presents a number of both mental and neurological symptoms of autoimmune encephalitis. Moreover, the coexistence of psychoses, neoplastic diseases and the methods of diagnosing autoimmune encephalitis are discussed...
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In the paper we present the case of 39-year old patient admitted to the hospital because of double cancer (i.e. breast and ovarian cancer). This coexistence made us to check with PCR the possible irregularity in BCRA1 gene structure. The... more
In the paper we present the case of 39-year old patient admitted to the hospital because of double cancer (i.e. breast and ovarian cancer). This coexistence made us to check with PCR the possible irregularity in BCRA1 gene structure. The result of the study was the finding of insertion-duplication 12 bp in BRCA1 gene.
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Adjuvant-induced arthritis (AA) in the rat is a T-cell mediated, chronic inflammatory stress in which circulating interleukin (IL)-6 levels are elevated. In addition, there are profound neuroendocrine changes associated with the... more
Adjuvant-induced arthritis (AA) in the rat is a T-cell mediated, chronic inflammatory stress in which circulating interleukin (IL)-6 levels are elevated. In addition, there are profound neuroendocrine changes associated with the development of hind-paw inflammation which have major implications for the ability of the rat to respond the to stress. Central injection of morphine is also able to increase circulating IL-6 concentration in control animals. In the present study we have determined the effects of a single injection of morphine into the lateral ventricle of control and AA animals on plasma corticosterone levels, on changes in plasma corticosterone and on IL-6 and IL-6 receptor mRNAs in the pituitary and adrenal gland. IL-6 and IL-6 receptor mRNAs were increased in the anterior pituitary of AA rats given moprhine compared with saline-treated AA rats. In the adrenal cortex, IL-6 mRNA was unaltered and IL-6 receptor mRNA was significantly decreased under these same conditions. AA rats were unable to mount corticosterone response to acute stress but were able to respond to acute stimulation with e.g. LPS. In the present study we found a sustained increase in plasma corticosterone in control animals which was still significantly elevated 2 hours following morphine injection, with a further significant increase in AA rats. These data suggest that alternative systems distinct from those activated in response to acute stress are activated by morphine in the AA animals. The similarity with the sustained increase in corticosterone following LPS injection suggest that either similar pathways are involved, or that central opiates may be involved in mediating HPA axis response to stress.
Research Interests: Animals, Corticosterone, Male, Morphine, Clinical Sciences, and 3 morePituitary Gland, Rats, and Interleukin
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Madelung disease-benign symetric lipomatosis--is uncommon condition affecting adults in age 30-60 years, characterized by symmetric accumulation of fatty tissue in the neck (type I), and upper back, shoulder girdle (type II). Type III is... more
Madelung disease-benign symetric lipomatosis--is uncommon condition affecting adults in age 30-60 years, characterized by symmetric accumulation of fatty tissue in the neck (type I), and upper back, shoulder girdle (type II). Type III is described as disproportionate accomodation of subcutaneous tissue in pelvic gridle. Pathogenesis of this disorder is not recognized well, but one of the most common risk factor is an alcohol consumption. In this paper a case of 60 years old man is described. Lipomatosis of neck started as single nodulus 6 years ago, and led to severe decrese of neck movements. As diagnosis has been established, the patient was surgicaly treated with good results.
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Interferon alpha (IFN-alpha) is a cytokine with pleiotropic effects which, via different pathways, influences the secretion of certain cytokines and hormones. Growth hormone (GH) secreted from the pituitary has physiological effects on... more
Interferon alpha (IFN-alpha) is a cytokine with pleiotropic effects which, via different pathways, influences the secretion of certain cytokines and hormones. Growth hormone (GH) secreted from the pituitary has physiological effects on various target tissues. The question is how IFN-alpha administered in various types of disease influences GH secretion. This study investigated the acute effect of IFN-alpha on GH mRNA expression in the rat anterior pituitary. The aim of the study was to measure the cellular expression of GH mRNA by in situ hybridisation in the anterior pituitary after a single administration of IFN-alpha. Rats were administered an intraperitoneal injection of IFN-alpha or saline. The rat pituitaries were taken 2 and 4 hours after IFN/saline administration and kept frozen until in situ hybridisation histochemistry. A 31-base(35)S-labelled oligonucleotide probe complementary to part of the exonic mRNA sequence coding for GH mRNA was used. All control and experimental s...
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Tumor Necrosis Factor alpha administered in the therapy of advanced cancer influences certain hormones and cytokines secretion. In turn, these also modulate the biological activity of Tumor Necrosis Factor alpha. It has been shown in... more
Tumor Necrosis Factor alpha administered in the therapy of advanced cancer influences certain hormones and cytokines secretion. In turn, these also modulate the biological activity of Tumor Necrosis Factor alpha. It has been shown in several studies that the cytokine Interleukin -6 (IL)-6 is produced in response to various hormones and other cytokines eg. Tumor Necrosis Factor (TNF alpha). In our study we focused on the Interleukin-6 (IL-6) secretion in response to TNF alpha administration in 12 patients undergoing TNF alpha biotherapy due to advanced neoplastic disease. Plasma IL-6 was estimated prior and at various time points (2, 3, 5 a,d 12 hours) after TNF alpha intravenous infusion. IL-6 level was estimated with ELISA method. In conclusion, we suggest the stimulating influence of hrec TNF alpha administered as therapy for advanced cancer on IL-6 secretion.
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Współistnienie u tego samego chorego dwóch lub więcej choróbz autoagresji nie jest zjawiskiem rzadkim. Najczęściej z innymichorobami współwystępuje toczeń rumieniowaty układowy (TRU).Nużliwość mięśni prążkowanych jest chorobą, której... more
Współistnienie u tego samego chorego dwóch lub więcej choróbz autoagresji nie jest zjawiskiem rzadkim. Najczęściej z innymichorobami współwystępuje toczeń rumieniowaty układowy (TRU).Nużliwość mięśni prążkowanych jest chorobą, której współistnieniez TRU nie jest zbyt częste, lecz sporadycznie pojawiały się jużopisy takich przypadków.W niniejszej pracy przedstawiono opis chorej z rozpoznaną nużliwościąmięśni prążkowanych, u której wykonano tymektomię i pokilkunastu latach od tego momentu rozpoznano zespół toczniopodobny.Dołączenie się boreliozy jeszcze bardziej skomplikowałoobraz kliniczny choroby. W pracy przedstawiono trudności diagnostyczne,jakie wystąpiły w obserwowanym przypadku.
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Współistnienie u tego samego chorego dwóch lub więcej choróbz autoagresji nie jest zjawiskiem rzadkim. Najczęściej z innymichorobami współwystępuje toczeń rumieniowaty układowy (TRU).Nużliwość mięśni prążkowanych jest chorobą, której... more
Współistnienie u tego samego chorego dwóch lub więcej choróbz autoagresji nie jest zjawiskiem rzadkim. Najczęściej z innymichorobami współwystępuje toczeń rumieniowaty układowy (TRU).Nużliwość mięśni prążkowanych jest chorobą, której współistnieniez TRU nie jest zbyt częste, lecz sporadycznie pojawiały się jużopisy takich przypadków.W niniejszej pracy przedstawiono opis chorej z rozpoznaną nużliwościąmięśni prążkowanych, u której wykonano tymektomię i pokilkunastu latach od tego momentu rozpoznano zespół toczniopodobny.Dołączenie się boreliozy jeszcze bardziej skomplikowałoobraz kliniczny choroby. W pracy przedstawiono trudności diagnostyczne,jakie wystąpiły w obserwowanym przypadku.
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Współistnienie u tego samego chorego dwóch lub więcej choróbz autoagresji nie jest zjawiskiem rzadkim. Najczęściej z innymichorobami współwystępuje toczeń rumieniowaty układowy (TRU).Nużliwość mięśni prążkowanych jest chorobą, której... more
Współistnienie u tego samego chorego dwóch lub więcej choróbz autoagresji nie jest zjawiskiem rzadkim. Najczęściej z innymichorobami współwystępuje toczeń rumieniowaty układowy (TRU).Nużliwość mięśni prążkowanych jest chorobą, której współistnieniez TRU nie jest zbyt częste, lecz sporadycznie pojawiały się jużopisy takich przypadków.W niniejszej pracy przedstawiono opis chorej z rozpoznaną nużliwościąmięśni prążkowanych, u której wykonano tymektomię i pokilkunastu latach od tego momentu rozpoznano zespół toczniopodobny.Dołączenie się boreliozy jeszcze bardziej skomplikowałoobraz kliniczny choroby. W pracy przedstawiono trudności diagnostyczne,jakie wystąpiły w obserwowanym przypadku.
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Vaccine hesitancy is a worrying phenomenon due to its range and health-related consequences. Secondary epidemiological data on the current situation of vaccination in Poland were analyzed. The source of the analyzed data were obtained... more
Vaccine hesitancy is a worrying phenomenon due to its range and health-related consequences. Secondary epidemiological data on the current situation of vaccination in Poland were analyzed. The source of the analyzed data were obtained from the reports of the National Sanitary Inspection and the National Institute of Public Health–National Institute of Hygiene in Warsaw. Legal basis on vaccination and the responsibilities of physicians related to these regulations were also discussed. Considering the opinions of ECDC experts, factors influencing vaccine hesitancy were identified. Attention was paid to the activities of the anti-vaccination movements, their range of activity and a strategy of action.
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Research Interests: Medicine and Reumatologia
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UNLABELLED Results of studies conducted around the world show a drastic deficiency vitamin D in almost all populations, and the strongest in the group of children and the elderly. The aim of this study was to evaluate the concentration of... more
UNLABELLED Results of studies conducted around the world show a drastic deficiency vitamin D in almost all populations, and the strongest in the group of children and the elderly. The aim of this study was to evaluate the concentration of vitamin D in children aged 10-12 years. MATERIAL AND METHODS The study included 42 children aged 10-12 years 24 girls and 18 boys).The obtained data were statistically analyzed using STATISTICA 10 (StatSoft Inc. Dell) RESULTS Half of the subjects (n = 21) had levels of vitamin D i not greater than 14.872 ng/ml (median). The median concentrations of vitamin D was higher in the studied group of boys than girls and amounted to 16.54 vs 14.02. Most patients (n = 18; 42.8%) had levels of vitamin D between 10 and 20 ng / ml (deficiency),7 persons (16.7%) had a severe deficiency (≤10 ng/ml), a significant number of patients (n = 15; 35 7%) had a slight deficiency of vitamin D called moderate hypovitaminosis. Only two individuals (4.8%) had concentrations ...
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Vaccine hesitancy is a worrying phenomenon due to its range and health-related consequences. Secondary epidemiological data on the current situation of vaccination in Poland were analyzed. The source of the analyzed data were obtained... more
Vaccine hesitancy is a worrying phenomenon due to its range and health-related consequences. Secondary epidemiological data on the current situation of vaccination in Poland were analyzed. The source of the analyzed data were obtained from the reports of the National Sanitary Inspection and the National Institute of Public Health–National Institute of Hygiene in Warsaw. Legal basis on vaccination and the responsibilities of physicians related to these regulations were also discussed. Considering the opinions of ECDC experts, factors influencing vaccine hesitancy were identified. Attention was paid to the activities of the anti-vaccination movements, their range of activity and a strategy of action.
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Madelung disease-benign symetric lipomatosis--is uncommon condition affecting adults in age 30-60 years, characterized by symmetric accumulation of fatty tissue in the neck (type I), and upper back, shoulder girdle (type II). Type III is... more
Madelung disease-benign symetric lipomatosis--is uncommon condition affecting adults in age 30-60 years, characterized by symmetric accumulation of fatty tissue in the neck (type I), and upper back, shoulder girdle (type II). Type III is described as disproportionate accomodation of subcutaneous tissue in pelvic gridle. Pathogenesis of this disorder is not recognized well, but one of the most common risk factor is an alcohol consumption. In this paper a case of 60 years old man is described. Lipomatosis of neck started as single nodulus 6 years ago, and led to severe decrese of neck movements. As diagnosis has been established, the patient was surgicaly treated with good results.
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Results of studies conducted around the world show a drastic deficiency vitamin D in almost all populations, and the strongest in the group of children and the elderly. The aim of this study was to evaluate the concentration of vitamin D... more
Results of studies conducted around the world show a drastic deficiency vitamin D in almost all populations, and the strongest in the group of children and the elderly. The aim of this study was to evaluate the concentration of vitamin D in children aged 10-12 years. The study included 42 children aged 10-12 years 24 girls and 18 boys).The obtained data were statistically analyzed using STATISTICA 10 (StatSoft Inc. Dell) Half of the subjects (n = 21) had levels of vitamin D i not greater than 14.872 ng/ml (median). The median concentrations of vitamin D was higher in the studied group of boys than girls and amounted to 16.54 vs 14.02. Most patients (n = 18; 42.8%) had levels of vitamin D between 10 and 20 ng / ml (deficiency),7 persons (16.7%) had a severe deficiency (≤10 ng/ml), a significant number of patients (n = 15; 35 7%) had a slight deficiency of vitamin D called moderate hypovitaminosis. Only two individuals (4.8%) had concentrations in the range defined as optimum. The res...
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Background. The aim of the study was a comparative analysis of syncope prodromal signs in patients with vasovagal syncope during head-up tilt test (HUTT) and their relationships with those reported before spontaneous episodes. Materials... more
Background. The aim of the study was a comparative analysis of syncope prodromal signs in patients with vasovagal syncope during head-up tilt test (HUTT) and their relationships with those reported before spontaneous episodes. Materials and methods.We investigated 80 patients (40 men and 40 women), aged 18–75 years with previously diagnosed vasovagal cause of syncope. In all the patients, clinical history according prodromal signs occurring before spontaneous syncopal episode and during HUTT was taken. Frequencies of occurrence of prodromal signs such as the following were analysed: general weakness, dyspnea, heart palpitation, cold sweats, feeling of hot/cold, visual disturbances, dizziness, tinnitus, headache and stomachache. Results. Prodromal signs were reported more frequently during HUTT when compared with spontaneous syncopal episode (91.3 vs. 98.8 %, p=0.001). All the prodromal signs that were analysed occurredmore frequently during headup tilt test. Statistical significance...
Background: The aim of the study was a comparative analysis of syncope provoking factors and prodromal signs in patients with vasovagal syncope with consideration given to gender. Materials and methods: We investigated 80 patients (40 men... more
Background: The aim of the study was a comparative analysis of syncope provoking factors and prodromal signs in patients with vasovagal syncope with consideration given to gender. Materials and methods: We investigated 80 patients (40 men and 40 women), aged 18–75 years with previously diagnosed vasovagal cause of syncope. History was obtained from all the patients, with consideration given to the total number of syncopal and presyncopal episodes and age at first syncope. Special attention was paid to the frequency of precipitating factors such as a supine, sitting or standing position, activity and prodromal signs. Results. In the studied group, the mean age at first syncope was significantly lower in women (23.2±10.7) as compared to men (30.7 ± 17.4). The mean total number of syncopal and presyncopal episodes was higher in women (13.3±11.0 vs. 7.8±6.6, p=0.02; 26.6±22.9 vs. 13.8±26.9, p=0.01) (Table 1). In the group of men, syncopal episodes were more frequent after urination and ...