Research Interests:
Research Interests:
Research Interests:
: Every day, new cases of cancer patients whose recovery is delayed by multidrug resistance and chemotherapy side effects are identified, which severely limit treatment options. One of the most recent advances in nanotechnology is the... more
: Every day, new cases of cancer patients whose recovery is delayed by multidrug resistance and chemotherapy side effects are identified, which severely limit treatment options. One of the most recent advances in nanotechnology is the effective usage of nanotechnology as drug carriers for cancer therapy. As a consequence, heterocyclic nanocarriers were put into practice to see whether they could have a better cure with positive results. The potential of a therapeutic agent to meet its desired goal is vital to its success in treating any disease. Heterocyclic moieties are molecules that have a wide variety of chemically therapeutic functions as well as a significant biological activity profile. Heterocyclic nanoformulations play an important role in cell physiology and as possible arbitrators for typical biological reactions, making them valuable in cancer research. As a result, experts are working with heterocyclic nanoformulation to discover alternative approaches to treat cancer. Due to their unique physicochemical properties, heterocyclic compounds are real cornerstones in medicinal chemistry and promising compounds for the future drug delivery system. This review briefly explores the therapeutic relevance of heterocyclic compounds in cancer treatment, various nanoformulation, and actively describes heterocyclic magnetic nano catalysts and heterocyclic moiety, as well as their mode of action, which have favorable anti-cancer effects.
Research Interests:
Research Interests:
The main objective of this review is to provide a comprehensive overview of the current evidence regarding the use of chitosan-based hydrogels to manage skin infections. Chitosan, a naturally occurring polysaccharide derived from chitin,... more
The main objective of this review is to provide a comprehensive overview of the current evidence regarding the use of chitosan-based hydrogels to manage skin infections. Chitosan, a naturally occurring polysaccharide derived from chitin, possesses inherent antimicrobial properties, making it a promising candidate for treating various dermal infections. This review follows a systematic approach to analyze relevant studies that have investigated the effectiveness of chitosan-based hydrogels in the context of dermal infections. By examining the available evidence, this review aims to evaluate these hydrogels’ overall efficacy, safety, and potential applications for managing dermal infections. This review’s primary focus is to gather and analyze data from different recent studies about chitosan-based hydrogels combating dermal infections; this includes assessing their ability to inhibit the growth of microorganisms and reduce infection-related symptoms. Furthermore, this review also con...
Research Interests:
: Lipids have received less attention than nucleic acids and proteins, which play a major role in building up the cell. They are a complex group of biomolecules varying in structure and function whose complexity can only be revealed by... more
: Lipids have received less attention than nucleic acids and proteins, which play a major role in building up the cell. They are a complex group of biomolecules varying in structure and function whose complexity can only be revealed by refining the present analytical tools. Lipogenesis is critical for tumor growth as it has been observed that FA (Fatty Acid) synthesis increases in many cancers. In this review, we have detailed the causes and concerns for considering lipids as a trademark for cancer, including other events such as mutations, epigenetic changes, chromosomal rearrangements, and hormonal stimulations. The process of biomarker development can be heightened from the critical changes observed in lipid profiling that occur in the reprogramming of lipid metabolism. The cancer alterations that occur during lipid metabolism and the expression of various genes during this process have been discussed in detail. The routes through which cancer cells source lipids for their nourishment and energy need and how FA synthesis contributes to this are discussed. The various pathways involved in the metabolism of lipid, which has the potential to be therapeutic targets, are highlighted. Also, the various driving factors critical for lipid metabolism alterations and the major role played by lipids in cancer and ways of targeting it are critically analyzed.
Research Interests:
Aims: Panitumumab (anti-Erb)-conjugated polycaprolactone (PCL) nanoparticles loaded with bosutinib (BTNB) were used to develop a targeted drug-delivery system for colon cancer cells. Materials & methods: Using carbodiimide coupling,... more
Aims: Panitumumab (anti-Erb)-conjugated polycaprolactone (PCL) nanoparticles loaded with bosutinib (BTNB) were used to develop a targeted drug-delivery system for colon cancer cells. Materials & methods: Using carbodiimide coupling, anti-Erb was conjugated to BTNB-loaded PCL nanoparticles. Dynamic light scattering, scanning electron microscopy, transmission electron microscopy, Fourier-transform infrared spectroscopy, differential scanning calorimetry, x-ray diffraction and thermogravimetric analysis were used to analyze nanoparticles. Results: According to in vitro studies, anti-Erb-BTNB-PCL nanoparticles inhibited HCT116 cells more than BTNB alone. Cell arrest at different phases was examined for apoptotic potential. An in vivo efficacy study showed that anti-Erb-BTNB-PCL nanoparticles could target tumors selectively. Conclusion: Anti-Erb-conjugated BTNB nanoparticles could specifically target colon cancer.
Research Interests:
: Cubosomes are a kind of nanoparticle that is distinct from solid particles in that they are liquid crystalline particles formed by self-assembly of a certain surfactant with a current water ratio. Their unique properties as a result of... more
: Cubosomes are a kind of nanoparticle that is distinct from solid particles in that they are liquid crystalline particles formed by self-assembly of a certain surfactant with a current water ratio. Their unique properties as a result of their microstructure are useful in practical applications. Cubosomes, specifically lyotropic nonlamellar liquid crystalline nanoparticles (LCNs) have gained acceptance as a medication delivery strategy for cancer and other disorders. Cubosomes are produced by the fragmentation of a solid-like phase into smaller particles. Because of its particular microstructure, which is physiologically safe and capable of allowing for the controlled release of solubilized compounds, cubic phase particles are garnering considerable attention. These cubosomes are highly adaptable carriers with promising theranostic efficacy because they can be given orally, topically, or intravenously. Throughout its operation, the drug delivery system regulates the loaded anticancer bioactive's target selectivity and drug release characteristics. This compilation examines recent advances and obstacles in the development and application of cubosomes to treat various cancers, as well as the challenges of turning it into a potential nanotechnological invasion.
Research Interests:
Research Interests:
Skin cancer is one of the most prominent diseases, affecting all continents worldwide, and has shown a significant rise in mortality and prevalence. Conventional therapy, including chemotherapy and surgery, has a few drawbacks. The... more
Skin cancer is one of the most prominent diseases, affecting all continents worldwide, and has shown a significant rise in mortality and prevalence. Conventional therapy, including chemotherapy and surgery, has a few drawbacks. The ethosomal systems would be thoroughly reviewed in this compilation, and they would be classified based on constituents: classical ethosomes, binary ethosomes, and transethosomes. Ethosomes systems are model lipid vesicular carriers with a substantial portion of ethanol. The impacts of ethosomal system components, preparation techniques, and their major roles in selecting the final characteristics of these nanocarriers are comprehensively reviewed in this chapter. The special techniques for ethosomes, including the cold approach, hot approach, injection method, mechanical dispersion method, and conventional method, are explained in this chapter. Various evaluation parameters of ethosomes were also explained. Furthermore, ethosomal gels, patches, and creams...
Research Interests:
: Microbubbles are a new kind of delivery system that may be used to treat a variety of illnesses, including cancer. Microbubble is a non-invasive technology that uses microscopic gas-filled colloidal particle bubbles with a size range of... more
: Microbubbles are a new kind of delivery system that may be used to treat a variety of illnesses, including cancer. Microbubble is a non-invasive technology that uses microscopic gas-filled colloidal particle bubbles with a size range of less than 100 micrometres. This unique carrier has been used in a variety of applications in the last decade, ranging from basic targeting to ultrasound-mediated drug delivery. The oxygen in the microbubble lasts longer in the water. The drug release mechanism is highly regulated, since it releases the medication only in the appropriate areas, increasing the local impact while reducing drug toxicity. This carrier is exceptional in cancer medication delivery because of its sustained stability, encapsulation efficiency, and drug targeting. In this paper, we provide a comprehensive analysis of microbubble technology, including its manufacturing techniques and use in cancer medication delivery, .
Research Interests:
Research Interests:
Research Interests: Medicine and Mucormycosis
Research Interests:
Research Interests:
Research Interests:
Three-dimensional (3D) printing technology is an emerging and flourishing technique which has a tremendous potential to bring a paradigm shift in the pharmaceutical sector. Basically, 3D printing is a fabrication technique in which... more
Three-dimensional (3D) printing technology is an emerging and flourishing technique which has a tremendous potential to bring a paradigm shift in the pharmaceutical sector. Basically, 3D printing is a fabrication technique in which automatically layer-by-layer materials are being deposited to create various design of choice. The primary objective of this manuscript is to discuss modern methods, techniques, and current trends, polymers of choice and recent applications of 3D printing technology applying in the pharmaceutical sector. Recently, the FDA has approved 3D printed tablet called Spritam, which brings a tremendous boost in the preparation of fabricated drug delivery system and personalized medicine. In this review, special importance was given to highlight the challenges and future perspectives of 3D printed technology in the pharmaceutical sector.
Research Interests:
Research Interests:
IntroductionThe study aimed to develop a nano-based drug delivery system for the treatment of hepatocellular carcinoma (HCC), a type of liver cancer that accounts for 90% of all liver malignancies. The study focused on the use of... more
IntroductionThe study aimed to develop a nano-based drug delivery system for the treatment of hepatocellular carcinoma (HCC), a type of liver cancer that accounts for 90% of all liver malignancies. The study focused on the use of cabozantinib (CNB), a potent multikinase inhibitor that targets the VEGF receptor 2, as the chemotherapeutic drug. We developed CNB-loaded nanoparticles made from Poly D, L-lactic-co-glycolic acid, and Polysarcosine (CNB-PLGA-PSar-NPs) for use in human HepG2 cell lines.MethodsBy O/W solvent evaporation method, the polymeric nanoparticles were prepared. The various techniques, such as photon correlation spectroscopy, scanning electron microscopy, and transmission electron microscopy were used, to determine the formulation's particle size, zeta potential, and morphology. SYBR Green/ROX qPCR Master Mix and RT-PCR equipment used to measure liver cancer cell line and tissue mRNA expression and MTT assay to test HepG2 cell cytotoxicity. Cell cycle arrest anal...
Research Interests:
Nanourchins are multibranched nanoparticles with unique optical properties and surface spikes. Because of their unique properties, gold nanourchins have advantages over gold nanoparticles. The most used nanourchins are gold, tungsten,... more
Nanourchins are multibranched nanoparticles with unique optical properties and surface spikes. Because of their unique properties, gold nanourchins have advantages over gold nanoparticles. The most used nanourchins are gold, tungsten, carbon, vanadium and sea urchins. The synthesis of various nanourchins and their clinical advancement are discussed in this review. ZFNs, TALENs and CRISPR/Cas9 are discussed to facilitate understanding of advancements in nanourchins. Nanourchins have been studied for Parkinson's disease, Alzheimer's disease and bioimaging. The synthesis of molybdenum diselenide nanourchins and their bioconjugations are also discussed. Nanourchins can be further explored to improve drug targeting and delivery. Researchers from several fields may contribute to the study of nanourchins as prospective nanocarriers with target specificity.
Research Interests:
Research Interests:
Research Interests:
: Lung cancer is the second leading cancer with a high rate of mortality. It can be treated using different intervention techniques such as chemotherapy, radiation therapy, surgical removal, photodynamic therapy. All of these... more
: Lung cancer is the second leading cancer with a high rate of mortality. It can be treated using different intervention techniques such as chemotherapy, radiation therapy, surgical removal, photodynamic therapy. All of these interventions lack specificity, which implies that it harms the normal cells adjacent to the infected ones. Nanotechnology provides a promising solution that increases the bioavailability of anticancer drugs at the tumor site with reduced toxicity and improved therapeutic efficacy. Nanotechnology also improved the way lung cancer is diagnosed and treated. Various types of nanocarriers like liposomes, polymeric nanoparticles, magnetic nanoparticles, and different theranostic approaches are already approved for medical use, while various are under clinical and preclinical stages. This review article covers the details pertaining to lung cancer, types of overexpressed receptors, and cutting-edge nanocarriers used for treating lung cancer at its specific target.
Research Interests:
Research Interests:
: Pickering Emulsion therapy is a novel approach to treating various human diseases, in-cluding cancer. Traditional cancer treatment modalities, such as surgery, radiation, radiotherapy, and immunotherapy, have only achieved minimal... more
: Pickering Emulsion therapy is a novel approach to treating various human diseases, in-cluding cancer. Traditional cancer treatment modalities, such as surgery, radiation, radiotherapy, and immunotherapy, have only achieved minimal success. Pickering emulsion in cancer therapeu-tics has given cancer patients a new hope. Pickering Emulsions have grown in popularity over the last 15 years, owing to their highly desirable properties, similar to those of ordinary emulsions, namely their excellent stability. This review focused on the benefits, drawbacks, characterization parameters (droplet size and strength, for example), opportunities, and different development pro-cedures of Pickering Emulsion for cancer diseases. This review also addressed recent developments in Pickering Emulsions' technological issues. It examined the advantages and disadvantages of us-ing such formulations for topical pharmaceutical and cosmetic applications instead of traditional surfactant-based methods. Pickering Emulsion's evolution as a multifunctional dosage form carrier reflects renewed optimism in the pharmaceutical and cosmetic industries.
Research Interests:
Non-Small Cell Lung Cancer (NSCLC) accounts for about 84% of all lung cancer types diagnosed so far. Every year, regardless of gender, the NSCLC targets many communities worldwide. 5-Fluorouracil (5-FU) is a uracil-analog anticancer... more
Non-Small Cell Lung Cancer (NSCLC) accounts for about 84% of all lung cancer types diagnosed so far. Every year, regardless of gender, the NSCLC targets many communities worldwide. 5-Fluorouracil (5-FU) is a uracil-analog anticancer compound. This drug tends to annihilate multiple tumour cells. But 5-FU's most significant obstacle is that it gets very easily metabolized in the blood, which eventually leads to lower anticancer activity. Therfore a perfect drug delivery system is needed to overcome all the associated challenges. In this experiment, an attempt was made to prepare 5-FU loaded poly lactic-co-glycolic acid nanoparticles using solvent evaporation method and subsequently observed the effect of molecular weight of poly lactic-co-glycolic acid, loading of poly lactic-co-glycolic acid, sonication period on the cytotoxic effect of 10 % w/w 5-FU loaded PLGA nanoparticles against human A549 Isogenic cell line. In this experiment, two points are more evident: first, poly lact...
Research Interests:
: Liposomes are one of the most versatile drug carriers due to their functional properties, such as higher biocompatibility, the ability to encapsulate hydrophilic and hydrophobic products, and higher biodegradability. Liposomes are a... more
: Liposomes are one of the most versatile drug carriers due to their functional properties, such as higher biocompatibility, the ability to encapsulate hydrophilic and hydrophobic products, and higher biodegradability. Liposomes are a better and more significant nanocarrier for cancer therapy. The key to developing a better cancer-targeted nanocarrier is the development of targeted liposomes using various approaches. Several traditional and novel liposome preparation methods are briefly discussed in this mini-review. The current state of liposome targeting, active and passive liposome targeting in cancer therapy, ligand directed targeting (antibody, aptamer, and protein/peptide-mediated targeting), and other miscellaneous approaches such as stimuli-responsive liposome-based targeting, autophagy inhibition mediated targeting, and curcumin loaded liposomal targeting are all discussed within. All of this gathered and compiled information will shed new light on liposome targeting strategies in cancer treatment and will pique the interest of aspiring researchers and academicians.
Research Interests:
Research Interests:
Research Interests:
In this article, we consider a random coefficient ARMA(p, q) model with stable roots and show that the distribution of the estimators of the model parameters is asymptotically normal. The rate of convergence to normality is then derived.
Research Interests: Mathematics, Applied Mathematics, Statistics, Numerical Analysis, Convergence Rate, and 11 moreMoving average, Normality, Estimator, ARMA model, Random Coefficients, Asymptotic distribution, Asymptotic normality, Statistical distribution theory, Rate of Convergence, Distribution Function, and Autoregressive Moving Average Model
The study aimed to create D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) nanostructured lipid carriers (NLC) of sorafenib tosylate (ST) as lymphatic delivery systems (LDDS) to fight Metastatic colorectal cancer. Initially,... more
The study aimed to create D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) nanostructured lipid carriers (NLC) of sorafenib tosylate (ST) as lymphatic delivery systems (LDDS) to fight Metastatic colorectal cancer. Initially, ST-SLN, ST-NLC, and ST-LNE were formulated considering oleic acid (OA), glycerol monolinoleate (GMO), glycerol monolinoleate (GML) as solid lipid and further characterised, and tested for stability. The most stable ST-NLC was fabricated with TPGS to produce ST-TPGS-NLC and evaluated by performing in vitro drug profiling, in vitro cytotoxicity, and apoptotic studies against human female colorectal adenocarcinoma cell lines (SW48 Cells PTEN). Stability studies on three lipidic nanoparticles (ST-SLN, ST-NLC, ST-LEN) showed particle size, polydispersity index, and zeta potential ranging from 165 nm to 298 nm, 0.125 to 0.288, and -31 mV to -16 mV. At 1600 minutes, more than 80% of ST-NLC1 was released, confirming the sustained release pattern of the formulati...
Research Interests:
Background: Breast cancer is the second leading cause of death in women worldwide. The extremely rapid rate of metastasis and the propensity to develop resistance to all non-traditional treatments make them equally difficult to treat,... more
Background: Breast cancer is the second leading cause of death in women worldwide. The extremely rapid rate of metastasis and the propensity to develop resistance to all non-traditional treatments make them equally difficult to treat, which are the causes of increased morbidity and death in breast melanoma patients. Experts all around the world have been focusing on the first detection of a breast lump so that action can be taken at the earliest possible time. Furthermore, traditional treatment procedures such as chemotherapy, radiation, and local surgical treatment suffer from a slew of drawbacks, including toxicity, normal cell genetic modification, and cancer cell spread to healthy tissues. As a result, new therapy regimens with little toxicity to normal cells must be developed very away. Methods: Iron oxide nanoparticles are still widely utilized for heat targeting and imaging of breast development cells. Using an external magnetic field, they can be coupled with medicines, prot...
: Acute Flaccid Myelitis is defined by the presence of Acute Flaccid Paralysis (AFP) and a spinal cord lesion on magnetic resonance imaging that is primarily limited to the grey matter. AFM is a difficult situation to deal with when you... more
: Acute Flaccid Myelitis is defined by the presence of Acute Flaccid Paralysis (AFP) and a spinal cord lesion on magnetic resonance imaging that is primarily limited to the grey matter. AFM is a difficult situation to deal with when you have a neurologic illness. According to the Centers for Disease Control and Prevention (CDC), a large number of cases were discovered in the United States in 2014, with 90% of cases occurring in children. Although the exact cause of AFM is unknown, mounting evidence suggests a link between AFM and enterovirus D68 (EV-D68). In 2014, an outbreak of AFM was discovered in the United States. The condition was initially linked to polioviruses; however, it was later found that the viruses were caused by non-polioviruses Enteroviruses D-68 (EV-D68). The number of cases has increased since 2014, and the disease has been declared pandemic in the United States. The sudden onset of muscle weakness, usually in an arm or leg, as well as pain throughout the body, the change in patient's facial expression (facial weakness), and shortness of breath, ingesting, and speaking are all common symptoms in patients suffering from neurologic disease. This article includes graphic and histogram representations of reported AFM incidents and criteria for causality, epidemiology, various diagnostic approaches, signs and symptoms, and various investigational guidelines. It also includes key statements about recent clinical findings related to AFM disease.
Research Interests:
: Oncolytic viruses replicate and spread in tumors at the same time, resulting in increased cytotoxicity and the reversal of tumor immune suppression. Among other viruses, recombinant adenoviruses that replicated in tumor cells were... more
: Oncolytic viruses replicate and spread in tumors at the same time, resulting in increased cytotoxicity and the reversal of tumor immune suppression. Among other viruses, recombinant adenoviruses that replicated in tumor cells were clinically tested via intratumoral or systemic administration. Although oncolytic virus replication kills tumor cells on its own, it may also activate the immune system, which can aid in tumor control. Viruses can be modified to improve their selectivity and effectiveness. Adenovirus genomes can be easily designed to incorporate various tumor-targeting pathways and therapeutic transgenes to improve antitumor properties. Poor tumor targeting, intratumoral expansion, and virocentric immune responses are all linked to low efficacy. As a result, more effective oncolytic adenoviruses that can be used alone or in combination with chemotherapy or immunotherapy are needed. Oncolytic Adenovirus (OAds) has long been considered a potential biotherapeutic agent against various cancers due to its ability to replicate cancer cells while remaining dormant in healthy cells selectively. Several preclinical studies using genetic engineering technology have increased antitumor OAds in various cancers in recent years. Systemic OAds administration is hampered by poor targeting tropism to healthy tissues, low-level ad receptors on tumor cells, and pre-existing neutralizing antibodies. Various discoveries have been made to overcome these barriers, including stem cells, nanoparticles, polymer shielding, extracellular vesicles, hydrogels, and microparticles (MPs). These carriers may improve Oncolytic viruses’ therapeutic efficacy by improving transfection, circulatory survival, cellular interactions, specific targeting, and immune response. The structure and biology of adenoviruses, the different types of OAds, and the efficacy of different carriers in the systemic administration of OAds were all examined in this review.
Research Interests:
: Colorectal cancer (CRC) is a common cancer that is one of the leading causes of cancer-related deaths around the world. The creation of new biomarkers for this disease is an important public health strategy for lowering the... more
: Colorectal cancer (CRC) is a common cancer that is one of the leading causes of cancer-related deaths around the world. The creation of new biomarkers for this disease is an important public health strategy for lowering the disease's mortality rate. According to new research, exosomes may be important sources of biomarkers in CRC. Exosomes are nanometer-sized membrane vesicles (30–200 nm) secreted by normal and cancer cells that transport RNA and proteins between cells and are thought to help with intercellular communication. Exosomes have been linked to CRC initiation and progression, and some differentially expressed RNAs and proteins in exosomes have been identified as potential cancer detection candidates. As a result, studying the relationship between exosomes and CRC may aid in the development of new biomarkers for the disease. This article discusses the importance of exosomes as biomarkers in the diagnosis of CRC, as well as their use in the treatment of CRC metastasis, chemoresistance, and recrudescence. We discuss the benefits and drawbacks of using exosomes as tumour markers, as well as the benefits and drawbacks of using exosomes as tumour markers. Method: The composites of the materials were synthesized using melt blending technique. The dielectric property of the produced materials were investigated using open ended coaxial probe technique. The dielectric constant values was used in the computational study of the composites using finite element method. Conclusion: From the electric field intensity, it was observed that the highest filler had the minimum transmitted intensity of 2185.87 v/m. Due to the high loss factor of 0.47 obtained for the 30 % filler content, waveguide terminators and other microwave components can be produced from this composite.
Research Interests:
Research Interests:
Nanosponges are nanosized drug carriers with a three-dimensional structure created by crosslinking polymers. They have the advantage of being able to hold a wide range of drugs of various sizes. Nanosponges come in a variety of shapes and... more
Nanosponges are nanosized drug carriers with a three-dimensional structure created by crosslinking polymers. They have the advantage of being able to hold a wide range of drugs of various sizes. Nanosponges come in a variety of shapes and sizes. They are distinguished by the research method used, the type of polymer used, and the type of drug they may contain. Nanosponges are superior to other delivery systems because they can provide a controlled drug release pattern with targeted drug delivery. The period of action, as well as the drug’s residence time, may be regulated. Since it is made of biodegradable materials, it has a low toxicity and is safe to use. The efficiency of drug encapsulation is determined by the size of the drug molecule and the amount of void space available. Cancer, enzyme and biocatalyst carrier, oxygen delivery, solubility enhancement, enzyme immobilization, and poison absorbent are some of the applications for nanosponges. The method of preparation, characte...
Research Interests:
Research Interests:
One of the most prevalent forms of oral cancer is oral squamous cell carcinoma (OSCC), a major cause of morbidity and mortality worldwide. Following a definite oral cancer diagnosis, OSCC is typically treated with a multidisciplinary... more
One of the most prevalent forms of oral cancer is oral squamous cell carcinoma (OSCC), a major cause of morbidity and mortality worldwide. Following a definite oral cancer diagnosis, OSCC is typically treated with a multidisciplinary approach including surgery, chemotherapy, and radiation. In contrast, conventional chemotherapy medicines may be ineffective and have a range of side effects. Many techniques have been proved and authorized for treatment and diagnostics of different types of oral cancer, while others are currently being investigated in clinical trials. This book chapter is aimed to explain the current preclinical status of nano-based techniques to successfully diagnose and treat OSCC. This book chapter would also emphasize recent theranostics approaches utilized to cure OSCC. Nanotechnology also improved cancer biomarker detection, making them faster and more sensitive. To overcome these constraints and improve in situ drug delivery, various nanoparticles have been empl...
Research Interests:
: Intellectual Property Rights (IPR) are intellectual privileges that allow authors and inventors to defend their original inventions from misuse or theft. With the assistance of algorithms, clinical science has taken on a different level... more
: Intellectual Property Rights (IPR) are intellectual privileges that allow authors and inventors to defend their original inventions from misuse or theft. With the assistance of algorithms, clinical science has taken on a different level in recent years. Various advanced tools can be used to investigate pharmacokinetics profiling, in silico experiments, receptor simulations, drug synergistic effects, and so on. Computational scientists are making continuous efforts to figure out how to connect business models in pharmacology. However, software theft and security rights remain major concerns for all. In order to avoid such violations, IPR compliance for R&D as well as promoting machine applications is critical. This compilation will illustrate diverse software concepts, the latest patent data structures, copyright management laws for software, trade secrets, compliance rights, software patenting and contracts, artificial technology priorities and problems, licenses, and case studies relating to IPR violations in pharmaceutical and other fields.
Research Interests:
The use of quantum technology to deliver drugs has the potential to increase the efficacy of many rare disease treatments. Semiconductor nanoparticles are a new type of treatment for life-threatening disorders. The term "quantum... more
The use of quantum technology to deliver drugs has the potential to increase the efficacy of many rare disease treatments. Semiconductor nanoparticles are a new type of treatment for life-threatening disorders. The term "quantum dots" refers to semiconductor nanoparticles. These quantum dots have a one-of-a-kind shape, size, fluorescence characteristics, and shape-dependent optoelectronic capacities. As a result, we believe that quantum dots' (QDs) has the potential to be destined as medication carriers, biosensors, and similarly much more. Due to improvements in research, medicinal, and clinical domains, an in-depth examination of Quantum dots is now possible. Quantum dots are also classed as carbon-based quantum dots, graphene-based quantum dots, and cadmium-based quantum dots, with variations in their main structure leading to the discovery of more comparable and diversified quantum dots. Semiconductor quantum dots, or QDs, have also made tremendous progress in the ...
Research Interests:
Colorectal cancer (CRC) was once thought to be a rare disease, but it has now become a common, ongoing, and life-threatening disorder. The cells of the colon and rectum have been tainted by this cancerous growth. Colorectal disease is on... more
Colorectal cancer (CRC) was once thought to be a rare disease, but it has now become a common, ongoing, and life-threatening disorder. The cells of the colon and rectum have been tainted by this cancerous growth. Colorectal disease is on the rise in agricultural countries as a result of a number of factors, including an aging population, unfavorable western dietary patterns, and an increase in risk factors such as alcohol consumption, lack of physical activity, and corpulence. For both primary and metastatic colorectal malignant growth, new methodologies have emerged. We examine the epidermal growth factor receptor (EGFR) pathway, new cytotoxic specialties such as capecitabine and Tegafur, irinotecan, oxaliplatin, angiogenesis inhibitors, and the EGFR mutation. FOLFOX (5-fluorouracil [5-FU]/leucovorin [LV] plus oxaliplatin) and FOLFIRI (5-FU/LV plus irinotecan) have both been shown to be effective cytotoxic medications for metastatic CRC, with typical survival rates of around 2 year...
Colorectal cancer (CRC) was once thought to be a rare disease, but it has now become a common, ongoing, and life-threatening disorder. The cells of the colon and rectum have been tainted by this cancerous growth. Colorectal disease is on... more
Colorectal cancer (CRC) was once thought to be a rare disease, but it has now become a common, ongoing, and life-threatening disorder. The cells of the colon and rectum have been tainted by this cancerous growth. Colorectal disease is on the rise in agricultural countries as a result of a number of factors, including an aging population, unfavorable western dietary patterns, and an increase in risk factors such as alcohol consumption, lack of physical activity, and corpulence. For both primary and metastatic colorectal malignant growth, new methodologies have emerged. We examine the epidermal growth factor receptor (EGFR) pathway, new cytotoxic specialties such as capecitabine and Tegafur, irinotecan, oxaliplatin, angiogenesis inhibitors, and the EGFR mutation. FOLFOX (5-fluorouracil [5-FU]/leucovorin [LV] plus oxaliplatin) and FOLFIRI (5-FU/LV plus irinotecan) have both been shown to be effective cytotoxic medications for metastatic CRC, with typical survival rates of around 2 year...
: “Pancreatic ductal adenocarcinoma (PDAC)” is forceful, nearly cureless, and all-around deadly among all tumors. The general 5-year endurance period below 10% has remained adamantly unaltered in the last 30 years, regardless of enormous... more
: “Pancreatic ductal adenocarcinoma (PDAC)” is forceful, nearly cureless, and all-around deadly among all tumors. The general 5-year endurance period below 10% has remained adamantly unaltered in the last 30 years, regardless of enormous clinical and therapeutic endeavors. The yearly number of deaths is more than the number of recently analyzed cases. Not a classic one, but “Carbohydrate Antigen CA19-9” remains the prevailing tool for diagnosis. MicroRNAs and non-invasive techniques are now incorporated for the effective prognosis of PDAC than just CA19-9. Mutated “Rat sarcoma virus Ras” conformation “V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRas” is 95% accountable for PDAC, and its active (GTP-bound) formation activates signaling cascade comprising “Rapidly accelerated fibrosarcoma Raf”/“Mitogen-activated protein kinase MEK”/ “Extracellular signal-regulated kinase ERK” with “Phosphoinositide 3-kinase PI3K”/ “protein kinase B Akt”/ “mammalian target of rapamycin mTOR” pathways. KRas has acquired the label of ‘undruggable’ since the crosstalk in the nexus of pathways compensates for Raf and PI3K signaling cascade blocking. It is arduous to totally regulate KRas-coordinated PDAC with traditional medicaments like “gemcitabine GEM” plus nab-paclitaxel/FOLFIRINOX. For long-haul accomplishments aiming at KRas, future endeavors should be directed to combinatorial methodologies to adequately block KRas pathways at different standpoints, for currently, they are contributing to healing PDAC. In this review article, we outline the function of KRas in carcinogenesis in PDAC, its signaling cascade, former techniques utilized in hindering Kras, current and future possibilities for targeting Kras.
IntroductionLimited evidence exists for healthcare resource utilization (HCRU) and costs associated with generalized myasthenia gravis (gMG), a rare autoimmune disorder, for adults in the United States.MethodsAdults with ≥1 diagnostic... more
IntroductionLimited evidence exists for healthcare resource utilization (HCRU) and costs associated with generalized myasthenia gravis (gMG), a rare autoimmune disorder, for adults in the United States.MethodsAdults with ≥1 diagnostic claim for MG between 2014 and 2019 were identified using Symphony Health's Integrated Dataverse®. Using a novel algorithm, HCRU and costs over 12 months following index dates were evaluated for patients with gMG including those with exacerbation events. For patients who experienced crisis events, HCRU and costs were analyzed during the 36 months preceding, during, and 12 months following the events.ResultsMean HCRU and costs were higher for newly diagnosed patients compared with previously diagnosed patients (hospitalizations: 0.46 vs. 0.34; all-cause costs: $26,419.20 vs. $24,941.47; direct costs for gMG treatments: $9,890.37 vs. $9,186.47) and further increased for patients with exacerbation events (hospitalizations: 0.72; all-cause costs: $43,73...
Research Interests:
: Artificial intelligence and robotics are two of the hottest and most recent technologies to emerge from the world of science. There is tremendous potential for these technologies to solve a wide range of pharmaceutical problems,... more
: Artificial intelligence and robotics are two of the hottest and most recent technologies to emerge from the world of science. There is tremendous potential for these technologies to solve a wide range of pharmaceutical problems, including the reduction of the enormous amounts of money and time invested in the drug discovery and development process, technical solutions related to the quality of drug products, and an increase in the demand for pharmaceuticals. Nanorobotics is a new subfield that has emerged from the field of robotics itself. This technique makes use of robots that are as small as nano- or micron-sized to diagnose diseases and deliver drugs to the targeted organ, tissue, or cell. These techniques, as well as their various applications in the pharmacy sector, are extensively discussed throughout this article. Internationally renowned pharmaceutical companies are collaborating with Artificial Intelligence behemoths in order to revolutionise the discovery and development process of potential drug molecules and to ensure the highest possible quality in their products.
Cryoprotectants are basically some chemical compounds which prevent cells or tissues from damage due to freezing. Mostly, verification and thawing process is used in cryopreservation. The various animal tissues, organs, lymphocytes,... more
Cryoprotectants are basically some chemical compounds which prevent cells or tissues from damage due to freezing. Mostly, verification and thawing process is used in cryopreservation. The various animal tissues, organs, lymphocytes, cartilages, bone marrow, and proteins can be stored using proper cryoprotectants. Optimization of cryoprotectants is a challenging task, as elevated concentration may cause cytotoxicity. In this article, we discussed the implication, challenges, and recent advances of cryoprotectants along with its types. The importance of cryobank system and its importance were also being emphasized in this article.