Chronic cigarette smoke exposure in vivo causes decreased conversion of [14C]arachidonic acid (AA... more Chronic cigarette smoke exposure in vivo causes decreased conversion of [14C]arachidonic acid (AA) to prostacyclin (PGI2) by isolated aortic tissue and increased conversion to thromboxane (TXA2) by isolated platelets from rats. Alterations in the PGL2/TXA2 balance may be part of the mechanism by which smoking increases the risk of cardiovascular disease. In order to ascertain whether the particulate phase of whole smoke alone could cause these changes, rats were administered smoke condensate in propylene glycol for 56 days via two Alzet (2ML4) osmotic pumps. Pumps containing vehicle, low dose (150 micrograms/hr) or high dose (300 micrograms/hr) condensate were implanted s.c. dorsal to the thoracic vertebrae in male Sprague-Dawley rats. Three-quarters of the condensate-treated rats developed fibrin cysts encapsulating the pumps. Cysts were not seen in vehicle-treated rats. Residual pump contents were weighed and analyzed by GLC to ensure condensate delivery. No significant difference...
I NTRODUCTION Microsituations teaching is an active learning tool developed from cognitive scienc... more I NTRODUCTION Microsituations teaching is an active learning tool developed from cognitive science and cognitive learning theory. This case-based approach bas been developed to address thé need to eeach problem-solving skills to l arge classes while conserving faculty and Cher resources. Since implementing this method in an endocrine pharmacology course, student performance on problem-solving examinations has improved. Additionally, student evaluation of thé method is extremely positive. In response to thé newly adopted American Council of Pharmaceutical Education accréditation standards, colleges of pharmacy are designing curricula that develop pharma-ceutical care skills through active learning and problem-solving activities. A goal of these standards is to change thé teachingllearning environment from primarily faculty-cen-tered and passive to student-centered and active. In re-sponse to a similar situation, over thé years many colleges of. medicine have adopted a teaching method...
Chronic cigarette smoke exposure in vivo causes decreased conversion of [14C]arachidonic acid (AA... more Chronic cigarette smoke exposure in vivo causes decreased conversion of [14C]arachidonic acid (AA) to prostacyclin (PGI2) by isolated aortic tissue and increased conversion to thromboxane (TXA2) by isolated platelets from rats. Alterations in the PGL2/TXA2 balance may be part of the mechanism by which smoking increases the risk of cardiovascular disease. In order to ascertain whether the particulate phase of whole smoke alone could cause these changes, rats were administered smoke condensate in propylene glycol for 56 days via two Alzet (2ML4) osmotic pumps. Pumps containing vehicle, low dose (150 micrograms/hr) or high dose (300 micrograms/hr) condensate were implanted s.c. dorsal to the thoracic vertebrae in male Sprague-Dawley rats. Three-quarters of the condensate-treated rats developed fibrin cysts encapsulating the pumps. Cysts were not seen in vehicle-treated rats. Residual pump contents were weighed and analyzed by GLC to ensure condensate delivery. No significant difference...
I NTRODUCTION Microsituations teaching is an active learning tool developed from cognitive scienc... more I NTRODUCTION Microsituations teaching is an active learning tool developed from cognitive science and cognitive learning theory. This case-based approach bas been developed to address thé need to eeach problem-solving skills to l arge classes while conserving faculty and Cher resources. Since implementing this method in an endocrine pharmacology course, student performance on problem-solving examinations has improved. Additionally, student evaluation of thé method is extremely positive. In response to thé newly adopted American Council of Pharmaceutical Education accréditation standards, colleges of pharmacy are designing curricula that develop pharma-ceutical care skills through active learning and problem-solving activities. A goal of these standards is to change thé teachingllearning environment from primarily faculty-cen-tered and passive to student-centered and active. In re-sponse to a similar situation, over thé years many colleges of. medicine have adopted a teaching method...
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