shree devi

ObjectivesThe 2019 pandemic of coronavirus disease (COVID-19) has prompted several efforts to find safe and effective drugs, but little is understood as to where early efforts were centered. Several clinical trials, both Allopathy and AYUSH medicines have been registered in the Clinical Trial Registry of India (CTRI). We aimed to characterize and extract relevant data registered under CTRI for COVID-19.Materials and MethodsA cross-sectional analysis was performed of clinical trials for the treatment of COVID-19 that were registered in the Clinical Trial Registry of India (CTRI) from 1st March 2020 to 22nd June 2020. Relevant trial records were downloaded, deduplicated, and independently analyzed by three reviewers.Main outcomesTrial intervention, design, sponsorship, phase of the trial, and indicated outcomes.Results233 COVID-19 clinical trials, was registered from India in CTRI. Out of these, 146 were Interventional trials, 84 Observational trials, and three Post-marketing surveill...

In Siddha system of medicine, Yogam (Yoga) forms an important part. Among the Siddhars dealt with yogam, Thirumoolar is notable. Siddhars have advised Yogam for all categories of people. Siddhars have strong knowledge in embryological growth and foetal development. They have advised do's and don'ts of pregnant women. The Yogam mentioned by Siddhars are all beneficial among pregnant women. This paper reviews about the types of Asanas beneficial for women in all the stages of pregnancy.

The medication of normal procedure shall be extra legitimate if the ailment is identified by using it's possess viewpoint. So the be taught was once aimed to determine the sensitivity and specificity of the Siddha diagnostic methodology. Siddha strongly advocacies every physician to seem into "what type of person is suffering from an ailment is most important than what variety of health problem he has". This holistic standpoint devises the protocol of each medication in Siddha. This distinctive primary is the delicate force and motive in the back of the existence of this method considering antiquity. Having the above mentioned unique standards in intellect, this paper tried to fully grasp the complexity and core basics of Siddha diagnostics which indeed pave solution to unique therapeutics. The medication of normal system shall be more legitimate if the disorder is diagnosed via its own point of view. So the learn was once aimed to check the sensitivity and specificity...

“KALLADAIPPU” (Urolithiasis) “KALPIRAMIYAM”(Urolithiasis) are the synonyms in Siddha and the term equated to renal calculi in allopathic system of medicines. An increasing affluence and adaptation of Western diet habits in many developing countries seem likely to contribute to the changes for the development of renal calculi. Siddha medicine describes certain formulations as Lithotriptic and diuretic which is used in the treatment of renal calculi successfully. This case reported again is an example that proves the efficacy of Siddha medicines for expulsion of renal stones. The synergistic action enhanced resulting in disintegration and elimination of urinary stones from urinary tract.

The medication of normal procedure shall be extra legitimate if the ailment is identified by using it’s possess viewpoint. So the be taught was once aimed to determine the sensitivity and specificity of the Siddha diagnostic methodology. Siddha strongly advocacies every physician to seem into “what type of person is suffering from an ailment is most important than what variety of health problem he has”. This holistic standpoint devises the protocol of each medication in Siddha. This distinctive primary is the delicate force and motive in the back of the existence of this method considering antiquity. Having the above mentioned unique standards in intellect, this paper tried to fully grasp the complexity and core basics of Siddha diagnostics which indeed pave solution to unique therapeutics. The medication of normal system shall be more legitimate if the disorder is diagnosed via its own point of view. So the learn was once aimed to check the sensitivity and specificity of the Siddha...

The objective of the study was focused on the antifungal activity of herbal plants obtained from Salem, Tamil Nadu. The collected fresh leaves of Cassia alata, Cynodon dactylon, Ocimum tenuiflorum, Curcuma aromatica and Hydnocarpus laurifolia were made into an ointment after standard processing. The ointment showed significant activity against the fungi Aspergillus niger. The aqueous extract of Cassia alata showed maximum relative percentage inhibition against Aspergillus niger (13±1mm). Minimum inhibitory concentration was performed by modified agar well diffusion method on Potato Dextrose Broth and Potato Dextrose Agar. Minimum inhibitory concentration values of aqueous extract of Cassia alata varied from 25-100 mg/ml. This result obtained here suggests that the extract bear antifungal metabolites and considered as the potential source for antifungal drug development.

Niosomes are nonionic surfactant vesicles that have potential applications in the delivery of hydrophobic or amphiphilic drugs. But it has certain drawbacks like physical stability such as aggregation, fusion and leaking, and has shown some inconvenience in transportation, distribution and storage. A novel drug delivery system, Proniosomes, a dry formulation minimizes all such problems related to niosomes. These proniosomes are used to produce niosomes within minutes by the addition of hot water followed by agitation and such proniosome-derived niosomes are as good as or even better than conventional niosomes. Proniosomes can be prepared using suitable carrier among the different carriers such as maltodextrin, sorbitol,lactose,mannitol,magnesium aluminum silicate,microcrystalline cellulose. The present study involves comparison of such carriers and criteria for selection of suitable carrier for the preparation of the proniosomes.

Intention of the study is to standardize Vajravalli Chooranam, a polyherbal components used in the Siddha system of treatment. Powder microscopy, physico-chemical parameters, preliminary phytochemical tests, qualitative inorganic test, TLC photograph documentation, HPTLC finger print profile new release at UV 254nm, UV 366nm before derivatization and in 540nm after derivatization have been carried out. All the information generated are traits to the drug below learn. The set of physicochemical parameters, TLC and HPTLC results could be valuable for first-rate control of the drug.

Natural product or natural product structures continued to play a highly significant role in the drug discovery and development process. Chundaivattral Chooranam (CVC) is a Siddha Polyherbal formulation. It consists of equal quantity of dried Solanum torvum, Murraya koenigii, Mangiferaindica, Carunrox burghianum, Phyllanthus embilica, Punica granatum, Trigonella foenumgraecum. In the siddha system of medicine, CVC has been used in non-specific diarrhoea. In the present study,the anti-bacterial study was conducted according to the agar diffusion method. Chloramphenicol was used as standard drug. The biological activities of CVC was evaluated for antibacterial properties againt pathogens. The chemical constitutes and the qualitative analysis of CVC was carried out using GC-MS and FTIR analysis for the identification of bioactive components. Results. Were expressed as mean value ± standard error of the mean (SEM). It was observed that Chundai vattral Chooranam herbal formulation (1mg/m...

Abraga Parpam (AP-S) is a herbo-mineral formulation which is prepared as per the Siddha classical text by the process of calcination. Apraga Bhasma (AP-A) is also available in the market. It has been decided to compare the standardization of the both the drugs available in the market. The present study focussed on standardization and quality control which are essential for the identification of drugs. So, that we can prevent adulteration and misidentification of herbo-mineral drugs. In this paper modern techniques such as SEM with EDAX were used to generate fingerprint for Abraga bhasma (AP-A). The SEM analysis showed the presence of nano and micro particles. Parallel standardization works are being carried out in AP-S. A comparative paper will be published in the near future.

Kara Sooda Sathu Parpam (KSSP) is a traditional Siddha Herbo- mineral drug. The aim of the present study was to standardize the physico-chemical traits of the Siddha herbo mineral formulation KSSP. Efforts have been made to lay down the analytical standards for Kara Sooda Sathu Parpam which were not found reported to till date. This paper appraises a detail study of physico-chemical properties, phytochemical constituents and heavy metal contents of the selected drug (KSSP) were analyzed. The total ash value was found to be 9.3 %w/w, acid insoluble ash value is 0.94%w/w, water soluble ash value is 5.5 %w/w, and loss of drying at 105 Âo c is  7.3 % w/w. The water soluble extractives and alcohol soluble extractives were found to be 8.67 % w/w and 5.0 % w/w. The ICP-OES reveals that the heavy metals such as Mercury, Lead, Arsenic, cadmium are present in the drug are below detected limit. HR-SEM analysis has been used to study particle size shape and distribution. The study highlights t...

The present study was to analyse the siddha drug arputha mathirai for anti ulcer activity in aspirin induced in rats. Arputha mathirai was used to treat eri gunmam (peptic ulcer). Arputha mathirai at the dose level 200mg/kg and 400mg/kg were administered orally. Anti-ulcer effects were compared with standard drug omeprazole 20mg/kg b.w.,p.o.). The effect was assessed by parameters like pH, free acidity, total acidity and ulcer index. These observations helped us to conclude that Arputha mathirai 200mg/kg and 400mg/kg is endowed with antiulcer property.

Background: “DOOR MAN” (Documentation Of Objectionable advertisement and Reporting under Magic and Remedies Act Notification) Android Mobile App is a pioneer app of its kind in AYUSH which helps in documenting, reporting and improve the communication of safety issues related to false claims, magic and misleading advertisements. Siddha Central Research Institute, Chennai is a Peripheral Pharmacovigilance Centre developed “DOOR MAN”, a free smartphone app which will be available on Android stores, after beta version deployment. In recent times, the incidence of false claims, magic and misleading advertisements with embellished claims on efficacy has increased by multiple folds. These Indian legislations govern the ‘Schedule J of Drugs and Cosmetics Rules’ and ‘Drugs and Magic Remedies Act’ advertisement related to drugs, treatments and procedures. As per the statement from Honourable Minister, Ministry of AYUSH has come across 804 instances of misleading advertisements/claims allegedl...

Gandhaga Parpam (GP) is a traditional Siddha Herbo-mineral medicine. The aim of the present study was to standardize the Gandhaga Parpam (GP). The physico-chemical characters like colour, ash values, pH value, Percentage yield and solubility were analysed and modern instrumental techniques such as Scanning Electron Microscopy (SEM), and inductively coupled plasma optical emission spectrometry (ICP-OES).The total ash value was found to be 9.79%w/w, acid insoluble ash value is 0.98%w/w, water soluble ash value is 5.5%w/w, Moisture content 8.80%w/w and Foreign organic matter 7.99%w/w. The pH value is 7.6 and yield of percentage is 46. The ICP-OES reveals that the heavy metals such as Mercury, Lead, Arsenic, cadmium are present in the drug are below detected limit. HR-SEM analysis has been used to study particle size shape and distribution. The SEM analysis of the sample showed the particle size of 100nm in the sample.

Background: Mobile phones have become integral part of human life. A mobile application helps in Delivering food and also helps to conduct Delivery. Apart from connectivity android and iPhone make ease of all activities.  One area of those applications is healthcare applications. “SiddAR” (Siddha Initiative for Documentation of Drug Adverse Reaction) Android Mobile App is a pioneer app of its kind in AYUSH which helps in documenting, reporting and improve the communication of safety issues related to adverse drug reaction. Siddha Central Research Institute, Chennai is a Peripheral Pharmacovigilance Centre developed “SiddAR”, a free smartphone app available on Android stores, for reporting adverse drug reactions and requesting drug safety information instantaneously. Aim: In AYUSH pharmacovigilance, contemporary documentation process involves in submission of reports through filled in physical forms / online forms. Rapidity in Reporting would be lifesaving and also helps to prevent m...

Siddha medicine one among the traditional medicine have become increasingly popular and their use is wide spread. Siddha medicines are the first line of treatment in liver diseases for a long time. A number of herbal prescriptions are available in the market. The present review is aimed at compiling data on promising phytochemicals from medicinal plants that have been tested in hepatotoxicity models using modern scientific system. Excessive drug therapy, environmental pollutants, hepatic cancer and alcoholic intoxicants are the main causes of liver disorders. More efforts are to be directed towards methodological scientific evaluation for their safety and efficacy by subjecting to vigorous preclinical studies followed by clinical trials to unravel the mysteries hidden in plants. This review article is attempted to compile reported hepatoprotective plants in Siddha system of medicine and the Siddha formulations employed to cure liver disorders.

Background: Medicinal plants are playing very active role in traditional medicines for the treatment of various ailments. Thiripala chooranam tablet, a polyherbal Siddha formulation is used for treating gastric ulcer, skin disease, constipation, piles, wounds, gum bleeding, liver diseases etc. Therapeutic efficacy of many Siddha formulations depends upon the standardization and authentication of medicinal plants used and hence ensures reproducible quality of herbal products which will lead to safety, quality and efficacy of end products. The drug is being used as a prophylactic and as treatment option in diabetes. However, its effect on prediabetes has not been carried out. The aim of the doctoral study is to evaluate the efficacy of Thiripala Chooranam tablet in Munnerizhivu (Impaired Glucose Tolerance -IGT). Objective: To interpret the characteristic parameters of Thiripala chooranam tablet to conform its identity, quality and purity. Methods: Thiripala chooranam tablet was evalua...

People are using medicinal plants for many decades for wellbeing, effectiveness, nativity, and reduced side effects. Herbs and herbal products partake been applied with evidence base to treat and avoid ailments all over times past. Written palm leaf manuscripts and literature about medicinal plants available in Sangam period age about 5000 years compare to the Sumerians and earliest records are recommended prior use of therapeutic plants in Siddha medicine. Due to adverse effects of synthetic products, in attendance is a shift towards AYUSH therapies and medicinal plants. However, share of global market by Indians in medicinal plants related to economy has not reached its mark due to lack of translation as products existing in another arena. This chapter deals about positioning India in world market and attempts to deal about areas where the strength of Siddha prevails to translate knowledge from the lab to layman as products.

Due to erratic climate change, vector-borne diseases started flaring up from the second half of the last decade. Siddha medicine has been used as a public health tool to effectively manage chikungunya and dengue in the epidemics that happened in 2008 and 2016. Tamil Nadu government has made enormous efforts to control vector-borne diseases. Due to which morbidity and mortality due to vector borne diseases came down compared with other states. Two official Siddha formulations, namely Kabasura Kudineer Chooranam and Nilavembu Kudineer Chooranam and novel herbal formulation – JACOM, are used to combat vector-borne diseases. These decoctions lack an evidence base as a formulation. Screening has been done to check the efficacy of the formulation in inhibiting neuraminidase. Neuraminidase inhibition assay was performed to determine the activity of Siddha formulations. The Kabasura Kudineer Chooranam, Nilavembu Kudineer Chooranam and JACOM showed excellent inhibitory activity. The Kabasura...

Standardization of Siddha formulations is a major step for establishment of biological activity, consistent chemical profile, or quality control for production and manufacturing of herbal drugs. Urai Mathirai (UM) is a Siddha polyherbal preparation comprising of Chukku (Zingiber officinale Roscoe), Adimathuram (Glycyrrhiza glabra L.), Akkirakaram (Anacyclus pyrethrum (L.) Lag.), Vashambu (Acorus calamus L.), Catikkai (Myristica fragrans Houtt.), Katukkai (Terminalia chebula Retz.), Masikkai (Quercus infectoria G.Olivier), Acanam (Allium sativum L.), Tippili (Piper longum L.) and Perunkayam (Ferula aasa-foetida L.). UM reduces accumulated Aiyam with ingredients having hot potency which increases Azhal. As UM is an important medicine in Siddha pediatrics the current study is aimed to standardize UM employing standard testing protocol for AYUSH drugs. Macroscopic authentication, powder microscopy and physico‐chemical studies like loss on drying, water soluble ash, acid insoluble ash, e...

Kabasura Kudineer (KSK) is a Sastric Siddha polyherbal formulation that has been used to treat the fever with influenza-like indication. The purpose of this study is to validate the antiviral activity of KSK against the novel SARS-CoV-2 virus. The antiviral activity of KSK against SARS-CoV-2 was assessed in Vero E6 cells and followed by an RT-PCR assay. KSK significantly inhibited SARS-CoV-2 replication in Vero E6 cells. These data indicate that KSK prevents the attack of its virus, rendering the use of these a novel COVID-19 infectious diseases strategy.

Objective: COVID19 pandemic out of all odds has created an opportunity to offer treatment in an integrative manner. This study measures the Length of stay (LS) of patients in an integrative way, as done earlier in China and Vietnam. Length of stay, Clinical presentations, and Comorbidities were analyzed among COVID19 patients in ESI Hospital, Coimbatore, Tamil Nadu, India. Method: Retrospective cross-sectional data on 251 Positive COVID19 patients of both sexes irrespective of age admitted from 27 March 2020 and 26 April 2020 cases were included in the study. The final discharge date is taken as 5th May 2020. Kaplan Meier survival analysis was adopted. Results: Male, female ratio were 141(56.2%): 83(33.1%), 12 (4.8%) Male Child and 15 (6.0%) were Female child. 5.2% of the patients were in the age group greater than 60, 75.3% were in the age group 20-60, and the remaining 19.5% were 0- 20 age group. 84.9% of patients were Asymptomatic, while fever and cough were the main symptoms rec...

Coronavirus disease 2019 (COVID‐19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2), a pandemic, which has led to the spread of mortality and morbidity all over the globe. In this dire situation, there is an urgent requirement for the development and immediate dissemination of treatment against COVID‐19. The traditional medicine system of Siddha can be utilized as preventive care to boost the immune system. The vast treasure of knowledge found in Siddha medicine can help in the betterment of humankind. Kabasura Kudineer (KSK) is from the ancient times present as an immune-boosting agent against several diseases. The present experimental setup to investigate the immunomodulatory and thrombolytic potential of KSK. The in vitro immunomodulatory models of phagocytosis of Candida albicans assay and nitro blue tetrazolium have demonstrated that KSK is giving better results compared with the controls (pooled serum, lipopolysaccharide, and streptokinase). The KSK at the concentrations of 12.5, 25, 50, and 100 μg/ml showed % immune-stimulations of 12.40 %, 20.81 %, 33.53 %, 43.20 % and for NBT showed 19.00 %, 25.50 %, 64.00 %, 71.00 % respectively. And similarly, the thrombolytic activity showed 50 and 100 μg/ml concentration showed 43.83 %, 71.83 % clot lysis respectively; and the control value for the streptokinase showed 83.78 %. Hence, it can be confirmed that KSK has immunomodulatory and thrombolytic properties in in vitro models, although the in vivo and the identification of KSK are to be discovered.

Classical Siddha medicine recommends the usage of functionally parallel substitute raw drugs in the scarcity of the original material. The concept of standard raw drug substitution is designated by the Tamil term Matru sarakku, which emphasizes selecting alternatives either in herbal or non-herbal sources based on certain attributes. Functionally similar materials are suggested for balancing the deficit based on such parameters. Literature sources from Siddha medicine and other allied subjects were explored and documented for the inclusive understanding of the concept of ideal substitution. Few of the standard substitutes mentioned in the classical Siddha literature were evaluated in a scientific account for its justification. An outlook on different specimens as described in the ancient texts of Tamil medicine indicates the usage of substitutes from numerous plants, animals, and other metallo-mineral ingredients. The rationale of selecting alternatives primarily depends on the equi...

Corona virus disease (COVID-19) is an infectious pandemic disease caused by the newly discovered novel corona virus. World Health Organization has declared the global health emergency due to COVID19 outbreak. Currently, there is no specific treatment or vaccine for fighting against this infectious disease. Aadathodai Kudineer is a drug indicated for Iya Erumal, Kozhai Kattu, Kabasuram. Upon the mortality and severity of the disease COVID19, we tried to identify the possible inhibition of phytocomponents of Aadathodai Kudineer in inhibiting Main Protease and ACE2 Receptor Spike protein SARS-CoV-2 through molecular docking studies. Methodology: In Silico molecular docking analysis was performed for phytocomponents present in the Aadathodai Kudineer formulation for targets main protease and ACE2 Receptor Spike protein, PDB ID: 6LU7 and PDB ID: 2AJF using Autodock tool. ADME properties was also predicted for all the above compounds. Results: Among the 9 active Phytocompounds present in ...

Siddha medicine, is a challenge to deliver the quality of medicine at each dose level due to the handmade preparations & processes as mentioned in siddha system of medicines. The present paper to survey the selected tablets available in the market and studied important quality parameters Disintegration test (DT) & Weight Variation (WV) as per the Indian pharmacopeia. The major Siddha market samples (Brahmananda Bairavam, Swasa Kudori Mathirai, Santha Chandrodayam, Vasantha Kusumakaram, Murukkanvidai, Vishnu chakram, Kungumapoo, Neerkovai, Balasanjeevi, Lavankathi) purchased from Different manufactures (B1, B2, B3, B4) and the DT (37±2°C, 45±2°C) & WV performed. The results indicate intake of Tablets with slight warm water will improve the tablet disintegration of Brahmananda Bairavam, Swasa Kudori Mathirai, Santha Chandrodayam, Vasantha Kusumakaram, Kungumapoo, Neerkovai, Balasanjeevi, Lavankathi. But there is no impact on Vishnu chakram & Murukkanvidai by using slight warm water. The results of DT (37.5°C) of Balasanjeevi (B4), Balasanjeevi (B4), Santha Chandrodayam (B4), Swasa Kudori Mathirai (B1, B2, B4), (B4) complies (within 15 minutes). The results of DT (45°C) of Balasanjeevi (B2, B4), Brahmananda Bairavam(B4), Santha Chandrodayam (B2, B4), Swasa Kudori Mathirai (B1, B2, B4), Vasantha Kusumakaram (B4), Vishnu chakram (B4), Kungumapoo (B2, B4) complies. The results of WV interoperated in statically T-test, Quality Control (±3 σ analysis) & the results implicated deviating from the control, specification limits. These tests bring out the errors, misbranded and bad quality of markedly available products & there is a need to improve regulatory standards to ensure the therapeutic and quality goals. Key words: Siddha Mathirai, Disintegration, Weight Variation, Siddha Tablet, Market Samples.