In this study, we investigated whether zerumbone (ZBN), ellagic acid (ELA) and quercetin (QCT), t... more In this study, we investigated whether zerumbone (ZBN), ellagic acid (ELA) and quercetin (QCT), the plant-derived components, can modulate the role of COX-3 or cytokines liable in arthritic disorder. Initially, the effect of ZBN, ELA, and QCT on inflammatory process was investigated using in-vitro models. In-silico docking and molecular dynamics study of these molecules with respective targets also corroborate with in-vitro studies. Further, the in-vivo anti-arthritic potential of these molecules in Complete Freund’s adjuvant (CFA)-induced arthritic rats was confirmed. CFA increases in TNF-α and IL-1β levels in the arthritic control animals were significantly (***p < 0.001) attenuated in the ZBN- and ELA-treated animals. CFA-induced attenuation in IL-10 levels recovered under treatment. Moreover, ELA attenuated CFA-induced upregulation of COX-3 and ZBN downregulated CFA-triggered NFκB expression in arthritic animals. The bonding patterns of zerumbone in the catalytic sites of tar...
Actaea acuminata (Wall. ex Royle) H. Hara (Himalayan Baneberry; Ranunculaceae) has been tradition... more Actaea acuminata (Wall. ex Royle) H. Hara (Himalayan Baneberry; Ranunculaceae) has been traditionally used in the treatment of various ailments especially in CNS related diseases. A survey of literature revealed that no scientific evidence exists on the safety of A. acuminata. The present investigations were undertaken with an objective to evaluate acute and sub-acute toxicity of methanol extract of A. acuminata roots in rats. After acute administration of 2000 mg/kg, p.o. of methanol extract to rats, behavioural changes were observed every hour for the first 6 h and every day for 14 days. In this acute toxicity studies, no behavioural changes were observed in animals. In sub-acute toxicity study, the methanol extract was administered to rats at the dose of 1000 mg/kg, p.o. for 28 days, and its effects on body weight, behavioural signs and histopathological parameters were evaluated. Sub-acute toxicity studies revealed no significant difference in the body weight of all the rats. To...
The health benefits of Sandal Wood Essential Oil can be attributed to its properties like anti se... more The health benefits of Sandal Wood Essential Oil can be attributed to its properties like anti septic, anti inflammatory, anti phlogistic, anti spasmodic, astringent, cicatrisant, carminative, diuretic, disinfectant, emollient, expectorant, hypotensive, memory booster, sedative and tonic.Sandalwood is an evergreen tree that is indigenous to India, the Sandal Oil and paste of Sandal is used in medicines, skin and beauty treatments and numerous industrial products including mouth fresheners, edibles, incense sticks, room fresheners, deodorants, perfumes, soaps, lotions, creams and others. It has some really remarkable medicinal properties.The medical properties reside in the oil, which can be pressed from the wood or extracted with alcohol or water. The antiseptic and disinfectant properties of the oil are similar to those of cubeb oil. The oil is used for bronchitis and for inflammation and infections in mucous tissue. A decoction of the wood may be helpful for indigestion, nephritis...
Actaea acuminata Wall. ex Royle, synonym of Actaea spicata var. acuminata (Wall. ex Royle) H.Hara... more Actaea acuminata Wall. ex Royle, synonym of Actaea spicata var. acuminata (Wall. ex Royle) H.Hara, commonly called the Himalayan Baneberry ( Ranunculaceae) has been investigated for various pharmacological activities, based on its traditional claims. Properly identified A. acuminata roots were defatted by extracting with petroleum ether. The marc was then extracted in a Soxhlet apparatus with methanol. Various pharmacological activities such as antianxiety (Elevated plus maze, Hole board and Light/Dark tests), anticonvulsant (Maximum electroshock test), antidepressant (Despair swim test), sedative (Actophotometer), antistress (Cold swim test), analgesic (Tail immersion test) and anti-inflammatory (Carrageenin-induced paw edema model) were evaluated after administration of 50, 100 or 200 mg/kg, p.o., doses of methanol extract. The methanol extract exhibited significant antianxiety, anticonvulsant, antidepressant and antistress activities, and mild sedative activity at a dose of 200 m...
International journal of medicinal mushrooms, 2018
Auricularia delicata, an edible mushroom, has been used as a traditional medicine in Manipur, Ind... more Auricularia delicata, an edible mushroom, has been used as a traditional medicine in Manipur, India, for various gastrointestinal and liver ailments. This study evaluates the antioxidant, antimicrobial, and hepatoprotective potential of A. delicata. A. delicata fruiting bodies were extracted with hexane, chloroform, ethyl acetate, and methanol. All these extracts were examined for in vitro antioxidant activity. To study antimicrobial activity, minimum inhibitory concentrations (milligrams per milliliter) were determined through the use of the broth dilution method. In vivo hepatoprotective activity against acetaminophen-induced hepatic injury in rats was investigated by evaluating serum biochemistry, antioxidant enzymes, and histopathology. With regard to antioxidant activity, 21 and 48 μg/mL were the lowest half-maximal effective concentrations, obtained for the methanol and ethyl acetate fractions, respectively. In the antimicrobial study, the ethyl acetate fraction showed the low...
Herbal Insecticides, Repellents and Biomedicines: Effectiveness and Commercialization, 2016
Northeastern India has a great range of ecological habitats due to its edaphic, climatic and alti... more Northeastern India has a great range of ecological habitats due to its edaphic, climatic and altitudinal variations, which made it the geographical “gateway” for much of India’s flora and fauna. Therefore, the region, being one of the richest areas of India in terms of biological values, has been in the spotlight for its high biodiversity and traditional knowledge and has been a priority for leading conservation agencies of the world. Ethnomedicobotany is one of the tools that help to deal with the direct relationship of plants and man to prevent and cure ailments. The indigenous medicinal plants grown in Northeastern India are useful folk medicines for the people of this region. In the present chapter, 320 medicinal plants have been listed which includes their traditional use, local name, region and parts used. These cover important medicinal plants used for traditional healthcare practices in the region and are also components of the available commercial herbal products. The World Health Organization (WHO) Collaborating Centres for Traditional Medicine reported that a total of 122 compounds identified in their survey were derived from only 94 plant species and 80 % of those plants were used for the same or related ethnomedical purposes. This provides an array of information about the rich indigenous knowledge on traditional medicine and the medicinal potential of the varied plants used by the local healers. This would prove to be an important resource for discovery of many bioactive principles. A comprehensive approach using systems biology could be the suitable way to prove the efficacy and to obtain information that might lead to the understanding of the mode of action.
Through one-to-one interaction with the traditional healers, the present study has identified 15 ... more Through one-to-one interaction with the traditional healers, the present study has identified 15 medicinal plant species traditionally used as remedies to control diabetes. The methanolic extracts were screened for their α-glucosidase inhibitory activity. Hypoglycemic activity was assessed following glucose, sucrose and starch tolerance test on normal and STZ induced diabetic rats. Ficus cunia extract had the highest α-glucosidase inhibitory potency with IC50 1.39±0.74µgmL(-1) followed by Schima wallichi (IC50 1.43±0.20µgmL(-1)) and Wendlandia glabrata (IC50 1.67±0.33µgmL(-1)). In STZ induced diabetic rat model, F. cunia and W glabrata extracts reduced blood glucose concentration to near normal up to 14 days when administered 48h after STZ. The present study supports the traditional use of some of these medicinal plants in anti-diabetic remedies. The present study contributes to evidence for use of traditional medicine.
The traditional use of Punica granatum has been reported to regulate urine discharge and control... more The traditional use of Punica granatum has been reported to regulate urine discharge and controls the burning sensation of urine. Materials and methods: Animals model of calcium oxalate urolithiasis was developed in male rats by adding ethylene glycol 0.75% in drinking water. The Punica granatum chloroform extract (PGCE) and Punica grantum methanol extract (PGME) orally at 100, 200 and 400 mg/kg, respectively, were administered along with ethylene glycol for 28 days. On 28 day, 24 h urine was collected from individual rats and used for estimation of urine calcium, phosphate and oxalate. The serum creatinine, urea and uric acid levels were estimated in each animal. The kidney homogenate was used for the estimation of renal oxalate contents. The paraffin kidney sections were prepared to observe the CaOx deposits. Results: The ethylene glycol control (Gr.-II) had significant (P < 0.001 vs. normal) increase in levels of urine oxalate, calcium and phosphate, serum creatinine, urea and uric acid and renal tissues oxalates, as compared to normal (Gr.-I). The paraffin kidney sections show significant histopathological changes. The treatment of PGCE and PGME at 100, 200 and 400 mg/kg doses, significantly (P < 0.001 vs. control) decreased the urine oxalate, calcium and phosphate, renal tissue oxalates and serum creatinine, urea and uric acid, in EG induced urolithiasis after 28 days. Conclusions: The PGCE and PGME at the doses of 400 mg/kg, found to be more effective in decreasing the urolithiasis and regeneration of renal tissues in male rats.
Actaea acuminata (Wall. ex Royle) H. Hara (Himalayan Baneberry; Ranunculaceae) has been tradition... more Actaea acuminata (Wall. ex Royle) H. Hara (Himalayan Baneberry; Ranunculaceae) has been traditionally used in the treatment of various ailments especially in CNS related diseases. A survey of literature revealed that no scientific evidence exists on the safety of A. acuminata. The present investigations were undertaken with an objective to evaluate acute and sub-acute toxicity of methanol extract of A. acuminata roots in rats. After acute administration of 2000 mg/kg, p.o. of methanol extract to rats, behavioural changes were observed every hour for the first 6 h and every day for 14 days. In this acute toxicity studies, no behavioural changes were observed in animals. In sub-acute toxicity study, the methanol extract was administered to rats at the dose of 1000 mg/kg, p.o. for 28 days, and its effects on body weight, behavioural signs and histopathological parameters were evaluated. Sub-acute toxicity studies revealed no significant difference in the body weight of all the rats. Toxicity signs such as piloerection, salivation and lacrimation were not observed. Histopathology examination of different organs (liver, kidney, spleen, lungs, brain, heart and testes) from both normal and treated groups revealed some architectural changes and detrimental effects in all organs of methanol extract treated animals. The crude methanol extract is a complex mixture of chemical constituents, thus, detailed investigations are needed in future to evaluate whether toxic effects are attributed to bioactive constituents or inactive part of methanol extract of A. acuminata.
This article appeared in a journal published by Elsevier. The attached copy is furnished to the a... more This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and educational use, including for instruction at the author's institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: http://www.elsevier.com/copyright
This article appeared in a journal published by Elsevier. The attached copy is furnished to the a... more This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: http://www.elsevier.com/copyright
Northeastern India has a great range of ecological habitats due to its edaphic, climatic and alti... more Northeastern India has a great range of ecological habitats due to its edaphic, climatic and altitudinal variations, which made it the geographical " gateway " for much of India's fl ora and fauna. Therefore, the region, being one of the richest areas of India in terms of biological values, has been in the spotlight for its high biodiversity and traditional knowledge and has been a priority for leading conservation agencies of the world. Ethnomedicobotany is one of the tools that help to deal with the direct relationship of plants and man to prevent and cure ailments. The indigenous medicinal plants grown in Northeastern India are useful folk medicines for the people of this region. In the present chapter, 320 medicinal plants have been listed which includes their traditional use, local name, region and parts used. These cover important medicinal plants used for traditional healthcare practices in the region and are also components of the available commercial herbal products. The World Health Organization (WHO) Collaborating Centres for Traditional Medicine reported that a total of 122 compounds identifi ed in their survey were derived from only 94 plant species and 80 % of those plants were used for the same or related ethnomedical purposes. This provides an array of information about the rich indigenous knowledge on traditional medicine and the medicinal potential of the varied plants used by the local healers. This would prove to be an important resource for discovery of many bioactive principles. A comprehensive approach using systems biology could be the suitable way
Northeastern India has a great range of ecological habitats due to its edaphic, climatic and alti... more Northeastern India has a great range of ecological habitats due to its edaphic, climatic and altitudinal variations, which made it the geographical " gateway " for much of India's fl ora and fauna. Therefore, the region, being one of the richest areas of India in terms of biological values, has been in the spotlight for its high biodiversity and traditional knowledge and has been a priority for leading conservation agencies of the world. Ethnomedicobotany is one of the tools that help to deal with the direct relationship of plants and man to prevent and cure ailments. The indigenous medicinal plants grown in Northeastern India are useful folk medicines for the people of this region. In the present chapter, 320 medicinal plants have been listed which includes their traditional use, local name, region and parts used. These cover important medicinal plants used for traditional healthcare practices in the region and are also components of the available commercial herbal products. The World Health Organization (WHO) Collaborating Centres for Traditional Medicine reported that a total of 122 compounds identifi ed in their survey were derived from only 94 plant species and 80 % of those plants were used for the same or related ethnomedical purposes. This provides an array of information about the rich indigenous knowledge on traditional medicine and the medicinal potential of the varied plants used by the local healers. This would prove to be an important resource for discovery of many bioactive principles. A comprehensive approach using systems biology could be the suitable way
In this study, we investigated whether zerumbone (ZBN), ellagic acid (ELA) and quercetin (QCT), t... more In this study, we investigated whether zerumbone (ZBN), ellagic acid (ELA) and quercetin (QCT), the plant-derived components, can modulate the role of COX-3 or cytokines liable in arthritic disorder. Initially, the effect of ZBN, ELA, and QCT on inflammatory process was investigated using in-vitro models. In-silico docking and molecular dynamics study of these molecules with respective targets also corroborate with in-vitro studies. Further, the in-vivo anti-arthritic potential of these molecules in Complete Freund’s adjuvant (CFA)-induced arthritic rats was confirmed. CFA increases in TNF-α and IL-1β levels in the arthritic control animals were significantly (***p < 0.001) attenuated in the ZBN- and ELA-treated animals. CFA-induced attenuation in IL-10 levels recovered under treatment. Moreover, ELA attenuated CFA-induced upregulation of COX-3 and ZBN downregulated CFA-triggered NFκB expression in arthritic animals. The bonding patterns of zerumbone in the catalytic sites of tar...
Actaea acuminata (Wall. ex Royle) H. Hara (Himalayan Baneberry; Ranunculaceae) has been tradition... more Actaea acuminata (Wall. ex Royle) H. Hara (Himalayan Baneberry; Ranunculaceae) has been traditionally used in the treatment of various ailments especially in CNS related diseases. A survey of literature revealed that no scientific evidence exists on the safety of A. acuminata. The present investigations were undertaken with an objective to evaluate acute and sub-acute toxicity of methanol extract of A. acuminata roots in rats. After acute administration of 2000 mg/kg, p.o. of methanol extract to rats, behavioural changes were observed every hour for the first 6 h and every day for 14 days. In this acute toxicity studies, no behavioural changes were observed in animals. In sub-acute toxicity study, the methanol extract was administered to rats at the dose of 1000 mg/kg, p.o. for 28 days, and its effects on body weight, behavioural signs and histopathological parameters were evaluated. Sub-acute toxicity studies revealed no significant difference in the body weight of all the rats. To...
The health benefits of Sandal Wood Essential Oil can be attributed to its properties like anti se... more The health benefits of Sandal Wood Essential Oil can be attributed to its properties like anti septic, anti inflammatory, anti phlogistic, anti spasmodic, astringent, cicatrisant, carminative, diuretic, disinfectant, emollient, expectorant, hypotensive, memory booster, sedative and tonic.Sandalwood is an evergreen tree that is indigenous to India, the Sandal Oil and paste of Sandal is used in medicines, skin and beauty treatments and numerous industrial products including mouth fresheners, edibles, incense sticks, room fresheners, deodorants, perfumes, soaps, lotions, creams and others. It has some really remarkable medicinal properties.The medical properties reside in the oil, which can be pressed from the wood or extracted with alcohol or water. The antiseptic and disinfectant properties of the oil are similar to those of cubeb oil. The oil is used for bronchitis and for inflammation and infections in mucous tissue. A decoction of the wood may be helpful for indigestion, nephritis...
Actaea acuminata Wall. ex Royle, synonym of Actaea spicata var. acuminata (Wall. ex Royle) H.Hara... more Actaea acuminata Wall. ex Royle, synonym of Actaea spicata var. acuminata (Wall. ex Royle) H.Hara, commonly called the Himalayan Baneberry ( Ranunculaceae) has been investigated for various pharmacological activities, based on its traditional claims. Properly identified A. acuminata roots were defatted by extracting with petroleum ether. The marc was then extracted in a Soxhlet apparatus with methanol. Various pharmacological activities such as antianxiety (Elevated plus maze, Hole board and Light/Dark tests), anticonvulsant (Maximum electroshock test), antidepressant (Despair swim test), sedative (Actophotometer), antistress (Cold swim test), analgesic (Tail immersion test) and anti-inflammatory (Carrageenin-induced paw edema model) were evaluated after administration of 50, 100 or 200 mg/kg, p.o., doses of methanol extract. The methanol extract exhibited significant antianxiety, anticonvulsant, antidepressant and antistress activities, and mild sedative activity at a dose of 200 m...
International journal of medicinal mushrooms, 2018
Auricularia delicata, an edible mushroom, has been used as a traditional medicine in Manipur, Ind... more Auricularia delicata, an edible mushroom, has been used as a traditional medicine in Manipur, India, for various gastrointestinal and liver ailments. This study evaluates the antioxidant, antimicrobial, and hepatoprotective potential of A. delicata. A. delicata fruiting bodies were extracted with hexane, chloroform, ethyl acetate, and methanol. All these extracts were examined for in vitro antioxidant activity. To study antimicrobial activity, minimum inhibitory concentrations (milligrams per milliliter) were determined through the use of the broth dilution method. In vivo hepatoprotective activity against acetaminophen-induced hepatic injury in rats was investigated by evaluating serum biochemistry, antioxidant enzymes, and histopathology. With regard to antioxidant activity, 21 and 48 μg/mL were the lowest half-maximal effective concentrations, obtained for the methanol and ethyl acetate fractions, respectively. In the antimicrobial study, the ethyl acetate fraction showed the low...
Herbal Insecticides, Repellents and Biomedicines: Effectiveness and Commercialization, 2016
Northeastern India has a great range of ecological habitats due to its edaphic, climatic and alti... more Northeastern India has a great range of ecological habitats due to its edaphic, climatic and altitudinal variations, which made it the geographical “gateway” for much of India’s flora and fauna. Therefore, the region, being one of the richest areas of India in terms of biological values, has been in the spotlight for its high biodiversity and traditional knowledge and has been a priority for leading conservation agencies of the world. Ethnomedicobotany is one of the tools that help to deal with the direct relationship of plants and man to prevent and cure ailments. The indigenous medicinal plants grown in Northeastern India are useful folk medicines for the people of this region. In the present chapter, 320 medicinal plants have been listed which includes their traditional use, local name, region and parts used. These cover important medicinal plants used for traditional healthcare practices in the region and are also components of the available commercial herbal products. The World Health Organization (WHO) Collaborating Centres for Traditional Medicine reported that a total of 122 compounds identified in their survey were derived from only 94 plant species and 80 % of those plants were used for the same or related ethnomedical purposes. This provides an array of information about the rich indigenous knowledge on traditional medicine and the medicinal potential of the varied plants used by the local healers. This would prove to be an important resource for discovery of many bioactive principles. A comprehensive approach using systems biology could be the suitable way to prove the efficacy and to obtain information that might lead to the understanding of the mode of action.
Through one-to-one interaction with the traditional healers, the present study has identified 15 ... more Through one-to-one interaction with the traditional healers, the present study has identified 15 medicinal plant species traditionally used as remedies to control diabetes. The methanolic extracts were screened for their α-glucosidase inhibitory activity. Hypoglycemic activity was assessed following glucose, sucrose and starch tolerance test on normal and STZ induced diabetic rats. Ficus cunia extract had the highest α-glucosidase inhibitory potency with IC50 1.39±0.74µgmL(-1) followed by Schima wallichi (IC50 1.43±0.20µgmL(-1)) and Wendlandia glabrata (IC50 1.67±0.33µgmL(-1)). In STZ induced diabetic rat model, F. cunia and W glabrata extracts reduced blood glucose concentration to near normal up to 14 days when administered 48h after STZ. The present study supports the traditional use of some of these medicinal plants in anti-diabetic remedies. The present study contributes to evidence for use of traditional medicine.
The traditional use of Punica granatum has been reported to regulate urine discharge and control... more The traditional use of Punica granatum has been reported to regulate urine discharge and controls the burning sensation of urine. Materials and methods: Animals model of calcium oxalate urolithiasis was developed in male rats by adding ethylene glycol 0.75% in drinking water. The Punica granatum chloroform extract (PGCE) and Punica grantum methanol extract (PGME) orally at 100, 200 and 400 mg/kg, respectively, were administered along with ethylene glycol for 28 days. On 28 day, 24 h urine was collected from individual rats and used for estimation of urine calcium, phosphate and oxalate. The serum creatinine, urea and uric acid levels were estimated in each animal. The kidney homogenate was used for the estimation of renal oxalate contents. The paraffin kidney sections were prepared to observe the CaOx deposits. Results: The ethylene glycol control (Gr.-II) had significant (P < 0.001 vs. normal) increase in levels of urine oxalate, calcium and phosphate, serum creatinine, urea and uric acid and renal tissues oxalates, as compared to normal (Gr.-I). The paraffin kidney sections show significant histopathological changes. The treatment of PGCE and PGME at 100, 200 and 400 mg/kg doses, significantly (P < 0.001 vs. control) decreased the urine oxalate, calcium and phosphate, renal tissue oxalates and serum creatinine, urea and uric acid, in EG induced urolithiasis after 28 days. Conclusions: The PGCE and PGME at the doses of 400 mg/kg, found to be more effective in decreasing the urolithiasis and regeneration of renal tissues in male rats.
Actaea acuminata (Wall. ex Royle) H. Hara (Himalayan Baneberry; Ranunculaceae) has been tradition... more Actaea acuminata (Wall. ex Royle) H. Hara (Himalayan Baneberry; Ranunculaceae) has been traditionally used in the treatment of various ailments especially in CNS related diseases. A survey of literature revealed that no scientific evidence exists on the safety of A. acuminata. The present investigations were undertaken with an objective to evaluate acute and sub-acute toxicity of methanol extract of A. acuminata roots in rats. After acute administration of 2000 mg/kg, p.o. of methanol extract to rats, behavioural changes were observed every hour for the first 6 h and every day for 14 days. In this acute toxicity studies, no behavioural changes were observed in animals. In sub-acute toxicity study, the methanol extract was administered to rats at the dose of 1000 mg/kg, p.o. for 28 days, and its effects on body weight, behavioural signs and histopathological parameters were evaluated. Sub-acute toxicity studies revealed no significant difference in the body weight of all the rats. Toxicity signs such as piloerection, salivation and lacrimation were not observed. Histopathology examination of different organs (liver, kidney, spleen, lungs, brain, heart and testes) from both normal and treated groups revealed some architectural changes and detrimental effects in all organs of methanol extract treated animals. The crude methanol extract is a complex mixture of chemical constituents, thus, detailed investigations are needed in future to evaluate whether toxic effects are attributed to bioactive constituents or inactive part of methanol extract of A. acuminata.
This article appeared in a journal published by Elsevier. The attached copy is furnished to the a... more This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and educational use, including for instruction at the author's institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: http://www.elsevier.com/copyright
This article appeared in a journal published by Elsevier. The attached copy is furnished to the a... more This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: http://www.elsevier.com/copyright
Northeastern India has a great range of ecological habitats due to its edaphic, climatic and alti... more Northeastern India has a great range of ecological habitats due to its edaphic, climatic and altitudinal variations, which made it the geographical " gateway " for much of India's fl ora and fauna. Therefore, the region, being one of the richest areas of India in terms of biological values, has been in the spotlight for its high biodiversity and traditional knowledge and has been a priority for leading conservation agencies of the world. Ethnomedicobotany is one of the tools that help to deal with the direct relationship of plants and man to prevent and cure ailments. The indigenous medicinal plants grown in Northeastern India are useful folk medicines for the people of this region. In the present chapter, 320 medicinal plants have been listed which includes their traditional use, local name, region and parts used. These cover important medicinal plants used for traditional healthcare practices in the region and are also components of the available commercial herbal products. The World Health Organization (WHO) Collaborating Centres for Traditional Medicine reported that a total of 122 compounds identifi ed in their survey were derived from only 94 plant species and 80 % of those plants were used for the same or related ethnomedical purposes. This provides an array of information about the rich indigenous knowledge on traditional medicine and the medicinal potential of the varied plants used by the local healers. This would prove to be an important resource for discovery of many bioactive principles. A comprehensive approach using systems biology could be the suitable way
Northeastern India has a great range of ecological habitats due to its edaphic, climatic and alti... more Northeastern India has a great range of ecological habitats due to its edaphic, climatic and altitudinal variations, which made it the geographical " gateway " for much of India's fl ora and fauna. Therefore, the region, being one of the richest areas of India in terms of biological values, has been in the spotlight for its high biodiversity and traditional knowledge and has been a priority for leading conservation agencies of the world. Ethnomedicobotany is one of the tools that help to deal with the direct relationship of plants and man to prevent and cure ailments. The indigenous medicinal plants grown in Northeastern India are useful folk medicines for the people of this region. In the present chapter, 320 medicinal plants have been listed which includes their traditional use, local name, region and parts used. These cover important medicinal plants used for traditional healthcare practices in the region and are also components of the available commercial herbal products. The World Health Organization (WHO) Collaborating Centres for Traditional Medicine reported that a total of 122 compounds identifi ed in their survey were derived from only 94 plant species and 80 % of those plants were used for the same or related ethnomedical purposes. This provides an array of information about the rich indigenous knowledge on traditional medicine and the medicinal potential of the varied plants used by the local healers. This would prove to be an important resource for discovery of many bioactive principles. A comprehensive approach using systems biology could be the suitable way
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