With the NUSEX detector, located at a depth of 5000 mwe in the Mt. Blanc Laboratory, the authors ... more With the NUSEX detector, located at a depth of 5000 mwe in the Mt. Blanc Laboratory, the authors observed 6357 single muons and 83 muon bundles during 6094.6 hr of effective running time. The authors have analysed these data in terms of (1) primary spectrum up to 100 TeV, (2) primary cosmic ray composition in the interval 1015-1017eV. Details of this analysis and preliminary results are reported.
ABSTRACT Particle Therapy (PT) is an emerging technique, which makes use of charged particles to ... more ABSTRACT Particle Therapy (PT) is an emerging technique, which makes use of charged particles to efficiently cure different kinds of solid tumors. The high precision in the hadrons dose deposition requires an accurate monitoring to prevent the risk of under-dosage of the cancer region or of over-dosage of healthy tissues. Monitoring techniques are currently being developed and are based on the detection of particles produced by the beam interaction into the target, in particular: charged particles, result of target and/or projectile fragmentation, prompt photons coming from nucleus de-excitation and back-to-back γ s, produced in the positron annihilation from β + emitters created in the beam interaction with the target. It has been showed that the hadron beam dose release peak can be spatially correlated with the emission pattern of these secondary particles. Here we report about secondary particles production (charged fragments and prompt γ s) performed at different beam and energies that have a particular relevance for PT applications: 12C beam of 80 MeV/u at LNS, 12C beam 220 MeV/u at GSI, and 12C, 4He, 16O beams with energy in the 50-300 MeV/u range at HIT. Finally, a project for a multimodal dose-monitor device exploiting the prompt photons and charged particles emission will be presented.
Four events have been recorded in the Mont Blanc nucleon decay experiment with all tracks fully c... more Four events have been recorded in the Mont Blanc nucleon decay experiment with all tracks fully contained in the detector volume. Three of them can be easily interpreted as due to interactions of atmospheric neutrinos. On the contrary it has been evaluated that the fourth event is ...
Nuclear Instruments & Methods in Physics Research Section a-Accelerators Spectrometers Detectors and Associated Equipment, 2003
... The evolution of the electron life-time at different conditions of the liquid phase purificat... more ... The evolution of the electron life-time at different conditions of the liquid phase purification ... prove the capability to provide fine grain spatial resolution allowing very good multiple tracks separation. ... This provides a 2D image of the ionization track projected on each wire plane. ...
The ATLAS detector at the LHC is used to search for high-mass states, such as heavy charged gauge... more The ATLAS detector at the LHC is used to search for high-mass states, such as heavy charged gauge bosons (W′), decaying to a charged lepton (electron or muon) and a neutrino. Results are presented based on the analysis of pp collisions at a center-of-mass ...
With the NUSEX detector, located at a depth of 5000 mwe in the Mt. Blanc Laboratory, the authors ... more With the NUSEX detector, located at a depth of 5000 mwe in the Mt. Blanc Laboratory, the authors observed 6357 single muons and 83 muon bundles during 6094.6 hr of effective running time. The authors have analysed these data in terms of (1) primary spectrum up to 100 TeV, (2) primary cosmic ray composition in the interval 1015-1017eV. Details of this analysis and preliminary results are reported.
ABSTRACT Particle Therapy (PT) is an emerging technique, which makes use of charged particles to ... more ABSTRACT Particle Therapy (PT) is an emerging technique, which makes use of charged particles to efficiently cure different kinds of solid tumors. The high precision in the hadrons dose deposition requires an accurate monitoring to prevent the risk of under-dosage of the cancer region or of over-dosage of healthy tissues. Monitoring techniques are currently being developed and are based on the detection of particles produced by the beam interaction into the target, in particular: charged particles, result of target and/or projectile fragmentation, prompt photons coming from nucleus de-excitation and back-to-back γ s, produced in the positron annihilation from β + emitters created in the beam interaction with the target. It has been showed that the hadron beam dose release peak can be spatially correlated with the emission pattern of these secondary particles. Here we report about secondary particles production (charged fragments and prompt γ s) performed at different beam and energies that have a particular relevance for PT applications: 12C beam of 80 MeV/u at LNS, 12C beam 220 MeV/u at GSI, and 12C, 4He, 16O beams with energy in the 50-300 MeV/u range at HIT. Finally, a project for a multimodal dose-monitor device exploiting the prompt photons and charged particles emission will be presented.
Four events have been recorded in the Mont Blanc nucleon decay experiment with all tracks fully c... more Four events have been recorded in the Mont Blanc nucleon decay experiment with all tracks fully contained in the detector volume. Three of them can be easily interpreted as due to interactions of atmospheric neutrinos. On the contrary it has been evaluated that the fourth event is ...
Nuclear Instruments & Methods in Physics Research Section a-Accelerators Spectrometers Detectors and Associated Equipment, 2003
... The evolution of the electron life-time at different conditions of the liquid phase purificat... more ... The evolution of the electron life-time at different conditions of the liquid phase purification ... prove the capability to provide fine grain spatial resolution allowing very good multiple tracks separation. ... This provides a 2D image of the ionization track projected on each wire plane. ...
The ATLAS detector at the LHC is used to search for high-mass states, such as heavy charged gauge... more The ATLAS detector at the LHC is used to search for high-mass states, such as heavy charged gauge bosons (W′), decaying to a charged lepton (electron or muon) and a neutrino. Results are presented based on the analysis of pp collisions at a center-of-mass ...
Particle therapy uses protons or 12C beams for the treatment of deep-seated solid tumors. Due
to ... more Particle therapy uses protons or 12C beams for the treatment of deep-seated solid tumors. Due to the features of the energy deposition of charged particles in matter, a limited amount of dose is released to the healthy tissue in the beam entrance region, while the maximum of the dose is released to the tumor at the end of the beam range, in the Bragg peak region. However nuclear interactions between beam and patient tissues induce fragmentation both of projectile and target. This has to be carefully taken into account since different ions have different effectiveness in producing a biological damage. In 12C treatments the main concern are long range forward emitted secondary ions produced in projectile fragmentation that release dose in the healthy tissue after the tumor. Instead, in a proton treatment, the target fragmentation produces low energy, short range fragments along all the beam range. The FOOT experiment (FragmentatiOn Of Target) is designed to study these processes. Target nuclei (16O,12C) fragmentation induced by 150-250 MeV proton beam will be studied by means of the inverse kinematic approach. 16O,12C therapeutic beams, at the quoted kinetic energy per nucleon, collide on graphite and hydrocarbons target. The cross section on Hydrogen can be then extracted by subtraction. This configuration explores also the projectile fragmentation of these 16O,12C beams, or other ions of therapeutic interest, such as 4He for instance. The detector includes a magnetic spectrometer based on silicon pixel and strip detectors, a scintillating crystal calorimeter able to stop the heavier produced fragments, and a DE detector, with TOF capability, to achieve the needed energy resolution and particle identification. In addition to the electronic apparatus, an alternative setup based on the concept of the “Emulsion Cloud Chamber”, coupled with the interaction region of the electronic FOOT setup, will provide the measurement of lighter charged fragments: protons, deuterons, tritons and Helium nuclei. The FOOT data taking is foreseen in the available experimental rooms existing in the presently operational charged particle therapy facilities in Europe, and possibly at GSI. An initial phase with the emulsion setup will start in early 2018, while the complete electronic detector will take data starting in 2019. In this work a general description of the FOOT experiment and of its expected performances is presented. 55th International Winter Meeting on Nuclear Physics 23-27 January, 2017 Bormio, Italy
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Papers by G. Battistoni
to the features of the energy deposition of charged particles in matter, a limited amount of dose
is released to the healthy tissue in the beam entrance region, while the maximum of the dose is
released to the tumor at the end of the beam range, in the Bragg peak region. However nuclear
interactions between beam and patient tissues induce fragmentation both of projectile and target.
This has to be carefully taken into account since different ions have different effectiveness in
producing a biological damage.
In 12C treatments the main concern are long range forward emitted secondary ions produced in
projectile fragmentation that release dose in the healthy tissue after the tumor. Instead, in a proton
treatment, the target fragmentation produces low energy, short range fragments along all the beam
range.
The FOOT experiment (FragmentatiOn Of Target) is designed to study these processes. Target
nuclei (16O,12C) fragmentation induced by 150-250 MeV proton beam will be studied by means
of the inverse kinematic approach. 16O,12C therapeutic beams, at the quoted kinetic energy per
nucleon, collide on graphite and hydrocarbons target. The cross section on Hydrogen can be then
extracted by subtraction. This configuration explores also the projectile fragmentation of these
16O,12C beams, or other ions of therapeutic interest, such as 4He for instance.
The detector includes a magnetic spectrometer based on silicon pixel and strip detectors, a scintillating
crystal calorimeter able to stop the heavier produced fragments, and a DE detector, with
TOF capability, to achieve the needed energy resolution and particle identification.
In addition to the electronic apparatus, an alternative setup based on the concept of the “Emulsion
Cloud Chamber”, coupled with the interaction region of the electronic FOOT setup, will provide
the measurement of lighter charged fragments: protons, deuterons, tritons and Helium nuclei.
The FOOT data taking is foreseen in the available experimental rooms existing in the presently
operational charged particle therapy facilities in Europe, and possibly at GSI. An initial phase
with the emulsion setup will start in early 2018, while the complete electronic detector will take
data starting in 2019.
In this work a general description of the FOOT experiment and of its expected performances is
presented.
55th International Winter Meeting on Nuclear Physics
23-27 January, 2017
Bormio, Italy