Books by Rafael Muñoz-Tamayo
Papers by Rafael Muñoz-Tamayo
International Dairy Journal, 2011
Process Biochemistry, 2012
Current opinion in biotechnology, Jan 26, 2015
The conversion of microalgae lipids and cyanobacteria carbohydrates into biofuels appears to be a... more The conversion of microalgae lipids and cyanobacteria carbohydrates into biofuels appears to be a promising source of renewable energy. This requires a thorough understanding of their carbon metabolism, supported by mathematical models, in order to optimize biofuel production. However, unlike heterotrophic microorganisms that utilize the same substrate as sources of energy and carbon, photoautotrophic microorganisms require light for energy and CO2 as carbon source. Furthermore, they are submitted to permanent fluctuating light environments due to outdoor cultivation or mixing inducing a flashing effect. Although, modeling these nonstandard organisms is a major challenge for which classical tools are often inadequate, this step remains a prerequisite towards efficient optimization of outdoor biofuel production at an industrial scale.
Journal of Theoretical Biology, 2010
FEMS Microbiology Ecology, 2011
2008 16th Mediterranean Conference on Control and Automation, 2008
15th IFAC Symposium on System Identification, 2009, 2009
Environmental Microbiology, 2009
Journal of Process Control, 2004
Mathematical models are expected to play a pivotal role for driving microalgal production towards... more Mathematical models are expected to play a pivotal role for driving microalgal production towards aprofitable process of renewable energy generation. To render models of microalgae growth useful toolsfor prediction and process optimization, reliable parameters need to be provided. This reliability impliesa careful design of experiments that can be exploited for parameter estimation. In this paper, we provideguidelines for the design of experiments with high informative content based on optimal experimenttechniques to attain an accurate parameter estimation. We study a real experimental device devotedto evaluate the effect of temperature and light on microalgae growth. On the basis of a mathematicalmodel of the experimental system, the optimal experiment design problem was formulated and solvedwith both static (constant light and temperature) and dynamic (time varying light and temperature)approaches. Simulation results indicated that the optimal experiment design allows for a more accurateparameter estimation than that provided by the existing experimental protocol. For its efficacy in termsof the maximum likelihood properties and its practical aspects of implementation, the dynamic approachis recommended over the static approach.
Biotechnology progress, Mar 2013
The industrial exploitation of microalgae is characterized by the production of high-value compou... more The industrial exploitation of microalgae is characterized by the production of high-value compounds. Optimization of the performance of microalgae culture systems is essential to
render the process economically viable. For raceway systems, the optimization based on optimal control theory is rather challenging, because the process is by essence periodically
forced and, as a consequence, optimization must be carried out in a periodic framework. In this article, we propose a simple operational criterion for raceway systems that when integrated
in a strategy of closed-loop control allows attaining biomass productivities very near to the theoretical maximal productivities. The strategy developed was tested numerically using a mathematical model of microalgae growth in raceways. The model takes into account the temporal variation of the environmental variables temperature and light intensity and their influence on microalgae growth.
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Books by Rafael Muñoz-Tamayo
Papers by Rafael Muñoz-Tamayo
render the process economically viable. For raceway systems, the optimization based on optimal control theory is rather challenging, because the process is by essence periodically
forced and, as a consequence, optimization must be carried out in a periodic framework. In this article, we propose a simple operational criterion for raceway systems that when integrated
in a strategy of closed-loop control allows attaining biomass productivities very near to the theoretical maximal productivities. The strategy developed was tested numerically using a mathematical model of microalgae growth in raceways. The model takes into account the temporal variation of the environmental variables temperature and light intensity and their influence on microalgae growth.
render the process economically viable. For raceway systems, the optimization based on optimal control theory is rather challenging, because the process is by essence periodically
forced and, as a consequence, optimization must be carried out in a periodic framework. In this article, we propose a simple operational criterion for raceway systems that when integrated
in a strategy of closed-loop control allows attaining biomass productivities very near to the theoretical maximal productivities. The strategy developed was tested numerically using a mathematical model of microalgae growth in raceways. The model takes into account the temporal variation of the environmental variables temperature and light intensity and their influence on microalgae growth.