Sylvester Addai-Arhin
Kumasi Polytechnic, Pharmaceutical science, Faculty Member
- I am a very professional person who loves to learn, teach and researchedit
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Sulfadoxine and pyrimethamine are often formulated together and used in the treatment of malaria especially in pregnant women serving as a prophylaxis. A new simple, precise and accurate reverse-phase high-performance liquid... more
Sulfadoxine and pyrimethamine are often formulated together and used in the treatment of malaria especially in pregnant women serving as a prophylaxis. A new simple, precise and accurate reverse-phase high-performance liquid chromatography (RP-HPLC) method has been developed for simultaneous identification and quantification of sulfadoxine and pyrimethamine in tablet dosage form. The analysis was carried out on Waters uBondapak C18 Column (39 × 300 mm, 3.6 µm) with acetonitrile: phosphate buffer (75:25 v/v) as the mobile phase at pH of 2.5, and a flow rate of 1.0 mL/min and a detection wavelength of 230 nm. Sulfadoxine and pyrimethamine eluted at mean times of 2.86 and 3.60 min, respectively. The method was linear with r2 values of 0.9976 and 0.9841 for sulfadoxine and pyrimethamine, respectively (range 31.25–500 µg/mL). The method was accurate (97.06 ± 2.23% and 99.81 ± 1.93% for sulfadoxine and pyrimethamine, respectively), precise, specific, robust, sensitive and cost effective. ...
Research Interests: Chemistry, Analytical Chemistry, Pharmacy, Chromatography, Pharmaceutical Chemistry, and 15 moreLinear models, Quality Control, Dosage Form, Pharmaceutical, Animals, Male, Rats, Reproducibility of Results, Food Sciences, Imidazoles, Flow Rate, Sensitivity and Specificity, Drug Stability, Pharmacology and pharmaceutical sciences, and limit of detection
A thesis submitted to the Department of Chemistry, Faculty of Physical Science, College of Science, Kwame Nkrumah University of Science and Technology in partial fulfilment for the requirements for the degree of Master of Philosophy in... more
A thesis submitted to the Department of Chemistry, Faculty of Physical Science, College of Science, Kwame Nkrumah University of Science and Technology in partial fulfilment for the requirements for the degree of Master of Philosophy in Analytical Chemistry, 2015
Research Interests:
Mercury (Hg), cadmium (Cd), and lead (Pb) concentrations in marketed cigarettes from South Korea, Vietnam, Japan, Indonesia, Taiwan, Thailand, the United Kingdom (UK), Belgium, Italy, Finland, and France were investigated. The cigarettes... more
Mercury (Hg), cadmium (Cd), and lead (Pb) concentrations in marketed cigarettes from South Korea, Vietnam, Japan, Indonesia, Taiwan, Thailand, the United Kingdom (UK), Belgium, Italy, Finland, and France were investigated. The cigarettes from Vietnam and Thailand had the highest trend of Hg. Meanwhile, Cd was found higher in cigarettes from Thailand, the UK, and Belgium. Pb concentrations in cigarettes from Belgium, the UK, and Korea were higher than others. The average of these heavy metals concentrated in cigarettes was in the order of Pb > Cd > Hg. Furthermore, the contents of these heavy metals in cigarette leaves were much higher than in filter and rolling paper. There was a significant positive correlation between Hg and Cd, but no correlation between Cd and Pb and between Hg and Pb. Significant positive correlations of nicotine with Hg and Cd but not Pb in the cigarette were observed. Activated carbon filters (Ce-C) absorb Cd and Pb from cigarette leaves and rolling pap...
Research Interests:
Urban dust has been contaminated with toxic heavy metals from various diffused sources. On August 28, 2019, the compact fluorescence lamp (CFL) factory that generates light for Rang Dong Light Source and Vacuum Flask in Hanoi City in... more
Urban dust has been contaminated with toxic heavy metals from various diffused sources. On August 28, 2019, the compact fluorescence lamp (CFL) factory that generates light for Rang Dong Light Source and Vacuum Flask in Hanoi City in Vietnam was accidentally fired. The assessment for Hg contamination and its human health impact 2 months after the incident was conducted in autumn 2019. The heavy Hg pollution is still found near CFL. Additionally, localized Hg pollution by air and wind direction was identified at sites in the northeast direction from CFL. Namely, in the area located downstream of the southwest monsoon wind, Hg had a trend higher than other directions. The hazard quotient (HQ) and the hazard index (HI) were evaluated by four routes of Hg exposure pathways. The HI values for children and adults in the most polluted site (Site 15) were 0.968 and 0.468, respectively. This meant that children who lived around this site and commuted to schools were the most at risk regardin...