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Article
Open AccessSpeg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads
Here we show that striated muscle preferentially expressed protein kinase α (Spegα) maintains cardiac function in hearts with Spegβ deficiency. Speg is required for stability of excitation-contraction coupling...
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Article
Open AccessMyoSight—semi-automated image analysis of skeletal muscle cross sections
Manual analysis of cross-sectional area, fiber-type distribution, and total and centralized nuclei in skeletal muscle cross sections is tedious and time consuming, necessitating an accurate, automated method o...
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Article
Open AccessAdaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation
Mutations in the skeletal muscle Ca2+ release channel, the type 1 ryanodine receptor (RYR1), cause malignant hyperthermia susceptibility (MHS) and a life-threatening sensitivity to heat, which is most severe in c...
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Article
Open AccessA chemical chaperone improves muscle function in mice with a RyR1 mutation
Mutations in the RYR1 gene cause severe myopathies. Mice with an I4895T mutation in the type 1 ryanodine receptor/Ca2+ release channel (RyR1) display muscle weakness and atrophy, but the underlying mechanisms are...