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Open AccessA gamepad-like nucleic acid testing device for rapid detection of SARS-CoV-2 via visible nested recombinase polymerase amplification
Nucleic acid tests are essential for the accurate diagnosis and control of infectious diseases. However, current assays are not easily scalable for a large population, due to the requirement of laboratory sett...
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Effects of Exogenous 2,4-Dichlorophenoxyacetic Acid, Glutathione, and L-Buthionine Sulfoximine on Intracellular Redox State and Hormone Levels and Their Links with Proliferation in Picea pungens Somatic Embryogenesis
Cellular redox state and hormone levels have important regulatory roles in the process of somatic embryogenesis (SE), but experimental data on the topic are limited in conifer SE. This study investigated chang...
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Article
A novel health state prediction approach based on artificial intelligence combination strategy for compensation capacitors in track circuit
The health management of railway signal equipment in the high-speed railway is a key link between intelligent operation and maintenance. Accurately predicting the health state of compensation capacitors is of ...
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Rational construction of high-active Co3O4 electrocatalysts for oxygen evolution reaction
Rational construction of high-efficiency electrocatalysts for oxygen evolution reaction (OER) is critical for renewable-energy technologies, but it is highly challenging to rationally regulate their surface st...
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Partitioning pattern of metals onto sediment particles in shallow lakes: an exponential decrease with increased particle size and its environmental implications
This research attempts to describe the partitioning pattern of metals with particle size distribution and to reveal its underlying mechanisms in natural sediments, in order to explain the variability of metal ...
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Transcriptome-wide identification of microRNAs in the roots of Pinus massoniana seedlings under Pi stress and Pi recovery
Phosphorus (Pi) deficiency is an important factor affecting plant growth and development, and there are still some gaps in the understanding of the underlying molecular mechanism of the response to low-Pi stre...
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Genetic analysis and identification of novel variations in Chinese patients with pediatric epilepsy by whole-exome sequencing
We aimed to investigate the genetic etiology of epilepsy in children, and to analyze the nature of genetic variation, the function of related genes, and the genotype-phenotype relationship. Moreover, the impac...
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Structural and thermodynamic factors in the adsorption process of anthocyanins from eggplant peel onto a carbon adsorbent
A simple method for the recovery of anthocyanins from eggplant peel by adsorption has been developed. Anthocyanins were extracted from eggplant peel and adsorbed onto three carbon adsorbents with different str...
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Open AccessArsenic compound sensitizes homologous recombination proficient ovarian cancer to PARP inhibitors
The poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors show survival benefits in ovarian cancer patients with BRCA1/2 mutation or homologous recombination (HR) deficiency, but only limited efficacy i...
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Open AccessMARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes
The membrane-associated RING-CH (MARCH) proteins are E3 ligases that regulate the stability of various cellular membrane proteins. MARCH8 has been reported to inhibit the infection of HIV-1 and a few other vir...
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Open AccessSARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation
SARS-CoV-2 is the pathogenic agent of COVID-19, which has evolved into a global pandemic. Compared with some other respiratory RNA viruses, SARS-CoV-2 is a poor inducer of type I interferon (IFN). Here, we rep...
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Open AccessPrenatal and postnatal diagnoses and phenotype of 8p23.3p22 duplication in one family
Distal 8p duplication is rare but clinically significant. Duplication syndrome results in variable phenotypes, such as developmental delay, intellectual disability, and malformation of the heart. We aimed to p...
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Open AccessLncRNA SPOCD1-AS from ovarian cancer extracellular vesicles remodels mesothelial cells to promote peritoneal metastasis via interacting with G3BP1
Metastasis is the key cause of death in ovarian cancer patients. To figure out the biological nature of cancer metastasis is essential for developing effective targeted therapy. Here we investigate how long no...
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Open AccessExosome-mediated transfer of CD44 from high-metastatic ovarian cancer cells promotes migration and invasion of low-metastatic ovarian cancer cells
To investigate the detailed roles and mechanisms of tumor-derived exosomes in progression and metastasis of ovarian cancer in vitro.
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Open AccessN6-methyladenosine regulates RNA abundance of SARS-CoV-2
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Open AccessThe kinetics of humoral response and its relationship with the disease severity in COVID-19
Coronavirus Disease 2019 (COVID-19) has caused a global pandemic. Here we profiled the humoral response against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by measuring immunoglobulin (Ig) A, ...
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Open AccessHumanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads worldwide and leads to an unprecedented medical burden and lives lost. Neutralizing antibodies provide efficient blockade for viral infectio...
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Open AccessActivation and evasion of type I interferon responses by SARS-CoV-2
The pandemic of COVID-19 has posed an unprecedented threat to global public health. However, the interplay between the viral pathogen of COVID-19, SARS-CoV-2, and host innate immunity is poorly understood. Her...
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Article
The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), which has become a public health emergency of international concern1. Angiotensin-converting enzym...
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Open AccessA case of prenatal diagnosis of 18p deletion syndrome following noninvasive prenatal testing
Chromosome 18p deletion syndrome is a disease caused by the complete or partial deletion of the short arm of chromosome 18, there were few cases reported about the prenatal diagnosis of 18p deletion syndrome. ...