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Article
Facile synthesis of poly(quinone-amine) based multifunctional photothermal nanoparticles for antibacterial and antitumor therapy
Photothermal therapy, as a therapeutic modality that uses photothermal agent (PTA) to convert light energy into thermal energy, has a promising future in the fields of bacterial clearance and tumor growth supp...
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Article
Open AccessNovel rapid molecular diagnosis methods for comprehensive genetic analysis of 21-hydroxylase deficiency
Molecular analysis of the CYP21A2 gene is highly important for understanding the aetiology of 21-hydroxylase deficiency (21-OHD). The aim of this study was to use a novel approach named CNVplex, together with ...
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Article
Open AccessPlanning of a Single Flow Channel in Valve Blocks Based on Additive Manufacturing and the Ant Colony Algorithm
As electro-hydrostatic actuator (EHA) technology advances towards lightweight and integration, the demand for enhanced internal flow pathways in hydraulic valve blocks intensifies. However, owing to the constr...
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Article
Peroxidase-like nanozyme based microenvironment-responsive injectable hydrogel for bacteria-infected wound healing
Hydrogel stands out as one of the most attractive wound dressings due to its excellent moisturizing properties and capacity to absorb wound exudates. However, conventional hydrogel dressings often lack respons...
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Article
Applications of in-situ spectroscopic techniques towards CO2 electroreduction
In-situ experimental techniques have been widely applied to uncover the dynamic evolutions of both the structure of catalysts and the interfacial property of catalysis, thus serving as the most important means to...
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Article
Mimicking the periosteum with dual function based on Au-coated PVDF electrospun membrane for guided bone regeneration: physical, electrical, and in vitro testing
A dual-functional material was fabricated to mimic the periosteum for guided bone regeneration. Poly(vinylidene fluoride) (PVDF) was fabricated into a gold-coated electrospun membrane. The gold-coated PVDF mem...
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Article
Open AccessCausative role of a novel intronic indel variant in FBN1 and maternal germinal mosaicism in Marfan syndrome
Marfan syndrome (MFS) is an autosomal dominant connective tissue disease with wide clinical heterogeneity, and mainly caused by pathogenic variants in fibrillin-1 (FBN1).
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Article
Open AccessPangenome and multi-tissue gene atlas provide new insights into the domestication and highland adaptation of yaks
The genetic diversity of yak, a key domestic animal on the Qinghai-Tibetan Plateau (QTP), is a vital resource for domestication and breeding efforts. This study presents the first yak pangenome obtained throug...
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Article
Synthesis of hydroxylamine from air and water via a plasma-electrochemical cascade pathway
Hydroxylamine is an important nitrogenous feedstock for the chemical industry. Conventional hydroxylamine synthesis methods utilize ammonia as the nitrogen source and require harsh reaction conditions, leading...
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Article
Biomimetic Lightweight Design of Legged Robot Hydraulic Drive Unit Shell Inspired by Geometric Shape of Fish Bone Rib Structure
The lightweight design of hydraulic quadruped robots, especially the lightweight design of the leg joint Hydraulic Drive Unit (HDU), can improve the robot's response speed, motion speed, endurance, and load ca...
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Article
Open AccessGenetic analysis of 37 cases with primary periodic paralysis in Chinese patients
Primary periodic paralysis (PPP) is an inherited disorders of ion channel dysfunction characterized by recurrent episodes of flaccid muscle weakness, which can classified as hypokalemic (HypoPP), normokalemic ...
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Article
Open AccessForce Compensation Control for Electro-Hydraulic Servo System with Pump–Valve Compound Drive via QFT–DTOC
Each joint of a hydraulic-driven legged robot adopts a highly integrated hydraulic drive unit (HDU), which features a high power–weight ratio. However, most HDUs are throttling-valve-controlled cylinder system...
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Article
Open AccessSpike structure of gold nanobranches induces hepatotoxicity in mouse hepatocyte organoid models
Gold nanoparticles (GNPs) have been extensively recognized as an active candidate for a large variety of biomedical applications. However, the clinical conversion of specific types of GNPs has been hindered du...
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Article
Control algorithm design of motorcycle semi-active suspension system via frequency division
Motorcycle experiences different vibrations on different road conditions. In order to improve the problem that the classical control algorithm cannot perfectly balance the driving comfort and road-holding perf...
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Article
Open AccessPrenatal diagnosis of 1408 foetuses at risk of DMD/BMD by MLPA and Sanger sequencing combined with STR linkage analysis
This study is a retrospective analysis of the prenatal genetic diagnosis results of 1408 foetuses at high risk of DMD/BMD to provide information for clinical genetic counselling.
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Article
Open AccessInsights into genetic diversity and phenotypic variations in domestic geese through comprehensive population and pan-genome analysis
Domestic goose breeds are descended from either the Swan goose (Anser cygnoides) or the Greylag goose (Anser anser), exhibiting variations in body size, reproductive performance, egg production, feather color, an...
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Article
A nonmulberry silk fibroin-based robust mandruka for rapid hemostasis treatment
Uncontrolled hemorrhage resulting from traumas causes severe health risks. There is an urgent need for expeditious hemostatic materials to treat bleeding incidents. Here, we developed a natural protein-based h...
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Article
High‑accuracy Impedance Compound Control of the Actuator for Periodic Gait of Legged Robots
Hydraulic driven legged robots have the advantage of large load capacity and strong environmental adaptability, which has a wide range of prospects for military and civilian applications. And its joint is driv...
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Article
Structural variations and environmental specificities of flowering time-related genes in Brassica napus
We found that the flowering time order of accessions in a genetic population considerably varied across environments, and homolog copies of essential flowering time genes played different roles in different lo...
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Article
Open AccessCase report: a Chinese girl like atypical Rubinstein–Taybi syndrome caused by a novel heterozygous mutation of the EP300 gene
Rubinstein–Taybi syndrome (RSTS) is an extremely rare autosomal dominant inheritable disorder caused by CREBBP and EP300 mutations, while atypical RSTS harbouring variant from the same genes but not obvious resem...
